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Items: 1 to 20 of 25

1.

Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism.

Li ME, Lauritzen HPMM, O'Neill BT, Wang CH, Cai W, Brandao BB, Sakaguchi M, Tao R, Hirshman MF, Softic S, Kahn CR.

Nat Commun. 2019 Jul 30;10(1):3412. doi: 10.1038/s41467-019-11265-y.

2.

12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.

Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Blüher M, Cypess AM, Kiebish MA, Spite M, Tseng YH.

Cell Metab. 2019 Oct 1;30(4):768-783.e7. doi: 10.1016/j.cmet.2019.07.001. Epub 2019 Jul 25.

PMID:
31353262
3.

Comparison of the efficacy and safety of once-daily insulin degludec/insulin aspart (IDegAsp) and long-acting second-generation basal insulin (insulin degludec and insulin glargine 300 units/mL) in insulin-naïve Japanese adults with type 2 diabetes: a pilot, randomized, controlled study.

Shimoda S, Sakamoto W, Hokamura A, Matsuo Y, Sekigami T, Ichimori S, Iwashita S, Ishii N, Otsu K, Yoshimura R, Nishiyama T, Sakaguchi M, Nishida K, Araki E.

Endocr J. 2019 Aug 29;66(8):745-752. doi: 10.1507/endocrj.EJ19-0179. Epub 2019 Jul 12.

4.

Mineralocorticoid Receptor May Regulate Glucose Homeostasis through the Induction of Interleukin-6 and Glucagon-Like peptide-1 in Pancreatic Islets.

Goto R, Kondo T, Ono K, Kitano S, Miyakawa N, Watanabe T, Sakaguchi M, Sato M, Igata M, Kawashima J, Motoshima H, Matsumura T, Shimoda S, Araki E.

J Clin Med. 2019 May 14;8(5). pii: E674. doi: 10.3390/jcm8050674.

5.

TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism.

Takahashi H, Alves CRR, Stanford KI, Middelbeek RJW, Pasquale Nigro, Ryan RE, Xue R, Sakaguchi M, Lynes MD, So K, Mul JD, Lee MY, Balan E, Pan H, Dreyfuss JM, Hirshman MF, Azhar M, Hannukainen JC, Nuutila P, Kalliokoski KK, Nielsen S, Pedersen BK, Kahn CR, Tseng YH, Goodyear LJ.

Nat Metab. 2019 Feb;1(2):291-303. doi: 10.1038/s42255-018-0030-7. Epub 2019 Feb 11.

6.

FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism.

Sakaguchi M, Cai W, Wang CH, Cederquist CT, Damasio M, Homan EP, Batista T, Ramirez AK, Gupta MK, Steger M, Wewer Albrechtsen NJ, Singh SK, Araki E, Mann M, Enerbäck S, Kahn CR.

Nat Commun. 2019 Apr 5;10(1):1582. doi: 10.1038/s41467-019-09418-0.

7.

Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo.

Batista TM, Garcia-Martin R, Cai W, Konishi M, O'Neill BT, Sakaguchi M, Kim JH, Jung DY, Kim JK, Kahn CR.

Cell Rep. 2019 Mar 19;26(12):3429-3443.e3. doi: 10.1016/j.celrep.2019.02.081.

8.

Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes.

Ramirez AK, Dankel S, Cai W, Sakaguchi M, Kasif S, Kahn CR.

Mol Metab. 2019 Apr;22:21-36. doi: 10.1016/j.molmet.2019.01.006. Epub 2019 Jan 25.

9.

Impact of hepatic HSP72 on insulin signaling.

Kitano S, Kondo T, Matsuyama R, Ono K, Goto R, Takaki Y, Hanatani S, Sakaguchi M, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E.

Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E305-E318. doi: 10.1152/ajpendo.00215.2018. Epub 2018 Dec 11.

PMID:
30532989
10.

Insulin regulates astrocyte gliotransmission and modulates behavior.

Cai W, Xue C, Sakaguchi M, Konishi M, Shirazian A, Ferris HA, Li ME, Yu R, Kleinridders A, Pothos EN, Kahn CR.

J Clin Invest. 2018 Jul 2;128(7):2914-2926. doi: 10.1172/JCI99366. Epub 2018 Jun 4.

11.

Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions.

Altindis E, Cai W, Sakaguchi M, Zhang F, GuoXiao W, Liu F, De Meyts P, Gelfanov V, Pan H, DiMarchi R, Kahn CR.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2461-2466. doi: 10.1073/pnas.1721117115. Epub 2018 Feb 21.

12.

Identification of microRNA that represses IRS-1 expression in liver.

Ono K, Igata M, Kondo T, Kitano S, Takaki Y, Hanatani S, Sakaguchi M, Goto R, Senokuchi T, Kawashima J, Furukawa N, Motoshima H, Araki E.

PLoS One. 2018 Jan 24;13(1):e0191553. doi: 10.1371/journal.pone.0191553. eCollection 2018.

13.

Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice.

Konishi M, Sakaguchi M, Lockhart SM, Cai W, Li ME, Homan EP, Rask-Madsen C, Kahn CR.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8478-E8487. doi: 10.1073/pnas.1710625114. Epub 2017 Sep 18.

14.

Corrigendum: Adipose-derived circulating miRNAs regulate gene expression in other tissues.

Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, Gorden P, Kahn CR.

Nature. 2017 May 10;545(7653):252. doi: 10.1038/nature22319. No abstract available.

PMID:
28492253
15.

Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.

Cai W, Sakaguchi M, Kleinridders A, Gonzalez-Del Pino G, Dreyfuss JM, O'Neill BT, Ramirez AK, Pan H, Winnay JN, Boucher J, Eck MJ, Kahn CR.

Nat Commun. 2017 Mar 27;8:14892. doi: 10.1038/ncomms14892.

16.

Adipose-derived circulating miRNAs regulate gene expression in other tissues.

Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, Gorden P, Kahn CR.

Nature. 2017 Feb 23;542(7642):450-455. doi: 10.1038/nature21365. Epub 2017 Feb 15. Erratum in: Nature. 2017 May 10;545(7653):252.

17.

Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.

Sakaguchi M, Fujisaka S, Cai W, Winnay JN, Konishi M, O'Neill BT, Li M, García-Martín R, Takahashi H, Hu J, Kulkarni RN, Kahn CR.

Cell Metab. 2017 Feb 7;25(2):448-462. doi: 10.1016/j.cmet.2016.12.008. Epub 2017 Jan 5.

18.

Antibiotic effects on gut microbiota and metabolism are host dependent.

Fujisaka S, Ussar S, Clish C, Devkota S, Dreyfuss JM, Sakaguchi M, Soto M, Konishi M, Softic S, Altindis E, Li N, Gerber G, Bry L, Kahn CR.

J Clin Invest. 2016 Dec 1;126(12):4430-4443. doi: 10.1172/JCI86674. Epub 2016 Oct 24.

19.

PI3-kinase mutation linked to insulin and growth factor resistance in vivo.

Winnay JN, Solheim MH, Dirice E, Sakaguchi M, Noh HL, Kang HJ, Takahashi H, Chudasama KK, Kim JK, Molven A, Kahn CR, Njølstad PR.

J Clin Invest. 2016 Apr 1;126(4):1401-12. doi: 10.1172/JCI84005. Epub 2016 Mar 14.

20.

BMP signaling and its modifiers in kidney development.

Nishinakamura R, Sakaguchi M.

Pediatr Nephrol. 2014 Apr;29(4):681-6. doi: 10.1007/s00467-013-2671-9. Epub 2013 Nov 12. Review.

PMID:
24217785

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