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Items: 1 to 20 of 56

1.

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors.

Svobodova B, Mezeiova E, Hepnarova V, Hrabinova M, Muckova L, Kobrlova T, Jun D, Soukup O, Jimeno ML, Marco-Contelles J, Korabecny J.

Biomolecules. 2019 Aug 19;9(8). pii: E379. doi: 10.3390/biom9080379.

2.

Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats.

Zdarova Karasova J, Soukup O, Korabecny J, Hroch M, Krejciova M, Hrabinova M, Misik J, Novotny L, Hepnarova V, Kuca K.

Drug Chem Toxicol. 2019 Jul 1:1-8. doi: 10.1080/01480545.2019.1566350. [Epub ahead of print]

PMID:
31257938
3.

Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer's Disease.

Kohelová E, Peřinová R, Maafi N, Korábečný J, Hulcová D, Maříková J, Kučera T, Martínez González L, Hrabinova M, Vorčáková K, Nováková L, De Simone A, Havelek R, Cahlíková L.

Molecules. 2019 Apr 3;24(7). pii: E1307. doi: 10.3390/molecules24071307.

4.

In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier.

Chlebek J, Korábečný J, Doležal R, Štěpánková Š, Pérez DI, Hošťálková A, Opletal L, Cahlíková L, Macáková K, Kučera T, Hrabinová M, Jun D.

Molecules. 2019 Apr 5;24(7). pii: E1340. doi: 10.3390/molecules24071340.

5.

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.

Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Zdarova Karasova J, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K.

Eur J Med Chem. 2019 Apr 15;168:491-514. doi: 10.1016/j.ejmech.2019.02.021. Epub 2019 Feb 27.

PMID:
30851693
6.

Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier.

Hamulakova S, Janovec L, Soukup O, Jun D, Janockova J, Hrabinova M, Sepsova V, Kuca K.

Curr Alzheimer Res. 2018;15(12):1096-1105. doi: 10.2174/1567205015666180711110750.

PMID:
29992880
7.

Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon.

Kuca K, Jun D, Junova L, Musilek K, Hrabinova M, da Silva JAV, Ramalho TC, Valko M, Wu Q, Nepovimova E, França TCC.

Molecules. 2018 May 7;23(5). pii: E1103. doi: 10.3390/molecules23051103.

8.

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings.

Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M, Vodakova E, Jun D, Nepovimova E, Valis M, Musilek K.

Drug Des Devel Ther. 2018 Mar 9;12:505-512. doi: 10.2147/DDDT.S133038. eCollection 2018.

9.

A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase.

Kuca K, Musilek K, Jun D, Zdarova-Karasova J, Nepovimova E, Soukup O, Hrabinova M, Mikler J, Franca TCC, Da Cunha EFF, De Castro AA, Valis M, Ramalho TC.

BMC Pharmacol Toxicol. 2018 Feb 21;19(1):8. doi: 10.1186/s40360-018-0196-3.

10.

In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?

Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K.

Med Chem. 2018;14(3):281-292. doi: 10.2174/1573406414666180112105657.

PMID:
29332594
11.

Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity.

Šafratová M, Hošťálková A, Hulcová D, Breiterová K, Hrabcová V, Machado M, Fontinha D, Prudêncio M, Kuneš J, Chlebek J, Jun D, Hrabinová M, Nováková L, Havelek R, Seifrtová M, Opletal L, Cahlíková L.

Arch Pharm Res. 2018 Feb;41(2):208-218. doi: 10.1007/s12272-017-1000-4. Epub 2017 Dec 14.

PMID:
29243039
12.

Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy.

Mezeiova E, Korabecny J, Sepsova V, Hrabinova M, Jost P, Muckova L, Kucera T, Dolezal R, Misik J, Spilovska K, Pham NL, Pokrievkova L, Roh J, Jun D, Soukup O, Kaping D, Kuca K.

Molecules. 2017 Jul 28;22(8). pii: E1265. doi: 10.3390/molecules22081265.

13.

Cholinesterase and Prolyl Oligopeptidase Inhibitory Activities of Alkaloids from Argemone platyceras (Papaveraceae).

Siatka T, Adamcová M, Opletal L, Cahlíková L, Jun D, Hrabinová M, Kuneš J, Chlebek J.

Molecules. 2017 Jul 14;22(7). pii: E1181. doi: 10.3390/molecules22071181.

14.

Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation.

Spilovska K, Korabecny J, Sepsova V, Jun D, Hrabinova M, Jost P, Muckova L, Soukup O, Janockova J, Kucera T, Dolezal R, Mezeiova E, Kaping D, Kuca K.

Molecules. 2017 Jun 16;22(6). pii: E1006. doi: 10.3390/molecules22061006.

15.

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.

Jeřábek J, Uliassi E, Guidotti L, Korábečný J, Soukup O, Sepsova V, Hrabinova M, Kuča K, Bartolini M, Peña-Altamira LE, Petralla S, Monti B, Roberti M, Bolognesi ML.

Eur J Med Chem. 2017 Feb 15;127:250-262. doi: 10.1016/j.ejmech.2016.12.048. Epub 2016 Dec 26.

PMID:
28064079
16.

Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules.

Hamulakova S, Poprac P, Jomova K, Brezova V, Lauro P, Drostinova L, Jun D, Sepsova V, Hrabinova M, Soukup O, Kristian P, Gazova Z, Bednarikova Z, Kuca K, Valko M.

J Inorg Biochem. 2016 Aug;161:52-62. doi: 10.1016/j.jinorgbio.2016.05.001. Epub 2016 May 5.

PMID:
27230386
17.

Isoquinoline Alkaloids from Fumaria officinalis L. and Their Biological Activities Related to Alzheimer's Disease.

Chlebek J, Novák Z, Kassemová D, Šafratová M, Kostelník J, Malý L, Ločárek M, Opletal L, Hošt'álková A, Hrabinová M, Kuneš J, Novotná P, Urbanová M, Nováková L, Macáková K, Hulcová D, Solich P, Pérez Martín C, Jun D, Cahlíková L.

Chem Biodivers. 2016 Jan;13(1):91-9. doi: 10.1002/cbdv.201500033.

PMID:
26765356
18.

Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs.

Bureš J, Jun D, Hrabinová M, Tachecí I, Květina J, Pavlík M, Rejchrt S, Douda T, Kuneš M, Kuča K, Kopáčová M.

Neuro Endocrinol Lett. 2015;36 Suppl 1:150-5.

PMID:
26757120
19.

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment.

Korabecny J, Andrs M, Nepovimova E, Dolezal R, Babkova K, Horova A, Malinak D, Mezeiova E, Gorecki L, Sepsova V, Hrabinova M, Soukup O, Jun D, Kuca K.

Molecules. 2015 Dec 10;20(12):22084-101. doi: 10.3390/molecules201219836.

20.

(+)-Chenabinol (Revised NMR Data) and Two New Alkaloids from Berberis vulgaris and their Biological Activity.

Novák Z, Hošt'álková A, Opletal L, Nováková L, Hrabinová M, Kuneš J, Cahlíková L.

Nat Prod Commun. 2015 Oct;10(10):1695-7.

PMID:
26669104

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