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Items: 1 to 20 of 143

1.

5'-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger.

Kumar P, Parmar RG, Brown CR, Willoughby JLS, Foster DJ, Babu IR, Schofield S, Jadhav V, Charisse K, Nair JK, Rajeev KG, Maier MA, Egli M, Manoharan M.

Chem Commun (Camb). 2019 Apr 25;55(35):5139-5142. doi: 10.1039/c9cc00977a.

PMID:
30977478
2.

Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates.

Janas MM, Zlatev I, Liu J, Jiang Y, Barros SA, Sutherland JE, Davis WP, Liu J, Brown CR, Liu X, Schlegel MK, Blair L, Zhang X, Das B, Tran C, Aluri K, Li J, Agarwal S, Indrakanti R, Charisse K, Nair J, Matsuda S, Rajeev KG, Zimmermann T, Sepp-Lorenzino L, Xu Y, Akinc A, Fitzgerald K, Vaishnaw AK, Smith PF, Manoharan M, Jadhav V, Wu JT, Maier MA.

Nucleic Acids Res. 2019 Apr 23;47(7):3306-3320. doi: 10.1093/nar/gkz140.

3.

No matter how: Top-down effects of verbal and semantic category knowledge on early visual perception.

Maier M, Abdel Rahman R.

Cogn Affect Behav Neurosci. 2019 Jan 3. doi: 10.3758/s13415-018-00679-8. [Epub ahead of print]

PMID:
30607831
4.

Error-related pupil dilation is sensitive to the evaluation of different error types.

Maier ME, Ernst B, Steinhauser M.

Biol Psychol. 2019 Feb;141:25-34. doi: 10.1016/j.biopsycho.2018.12.013. Epub 2018 Dec 29.

PMID:
30597189
5.

An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema.

Liu J, Qin J, Borodovsky A, Racie T, Castoreno A, Schlegel M, Maier MA, Zimmerman T, Fitzgerald K, Butler J, Akinc A.

RNA. 2019 Feb;25(2):255-263. doi: 10.1261/rna.068916.118. Epub 2018 Nov 21.

PMID:
30463937
6.

Native Language Promotes Access to Visual Consciousness.

Maier M, Abdel Rahman R.

Psychol Sci. 2018 Nov;29(11):1757-1772. doi: 10.1177/0956797618782181. Epub 2018 Sep 24.

PMID:
30248272
7.

Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.

Harp JM, Guenther DC, Bisbe A, Perkins L, Matsuda S, Bommineni GR, Zlatev I, Foster DJ, Taneja N, Charisse K, Maier MA, Rajeev KG, Manoharan M, Egli M.

Nucleic Acids Res. 2018 Sep 19;46(16):8090-8104. doi: 10.1093/nar/gky703.

8.

Novel model coupling approach for resilience analysis of coastal plant communities.

Schibalski A, Körner K, Maier M, Jeltsch F, Schröder B.

Ecol Appl. 2018 Sep;28(6):1640-1654. doi: 10.1002/eap.1758. Epub 2018 Jun 26.

PMID:
29862603
9.

Reversal of siRNA-mediated gene silencing in vivo.

Zlatev I, Castoreno A, Brown CR, Qin J, Waldron S, Schlegel MK, Degaonkar R, Shulga-Morskaya S, Xu H, Gupta S, Matsuda S, Akinc A, Rajeev KG, Manoharan M, Maier MA, Jadhav V.

Nat Biotechnol. 2018 Jul;36(6):509-511. doi: 10.1038/nbt.4136. Epub 2018 May 14.

PMID:
29786096
10.

Total Synthesis of Biselyngbyolide B and Its C21-C22 Z-Isomer.

Kämmler L, Maier ME.

J Org Chem. 2018 Apr 20;83(8):4554-4567. doi: 10.1021/acs.joc.8b00298. Epub 2018 Apr 3.

PMID:
29589751
11.

Group-Level EEG-Processing Pipeline for Flexible Single Trial-Based Analyses Including Linear Mixed Models.

Frömer R, Maier M, Abdel Rahman R.

Front Neurosci. 2018 Feb 6;12:48. doi: 10.3389/fnins.2018.00048. eCollection 2018.

12.

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.

Janas MM, Schlegel MK, Harbison CE, Yilmaz VO, Jiang Y, Parmar R, Zlatev I, Castoreno A, Xu H, Shulga-Morskaya S, Rajeev KG, Manoharan M, Keirstead ND, Maier MA, Jadhav V.

Nat Commun. 2018 Feb 19;9(1):723. doi: 10.1038/s41467-018-02989-4.

13.

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates.

Foster DJ, Brown CR, Shaikh S, Trapp C, Schlegel MK, Qian K, Sehgal A, Rajeev KG, Jadhav V, Manoharan M, Kuchimanchi S, Maier MA, Milstein S.

Mol Ther. 2018 Mar 7;26(3):708-717. doi: 10.1016/j.ymthe.2017.12.021. Epub 2018 Jan 4.

14.

Errors can elicit an error positivity in the absence of an error negativity: Evidence for independent systems of human error monitoring.

Di Gregorio F, Maier ME, Steinhauser M.

Neuroimage. 2018 May 15;172:427-436. doi: 10.1016/j.neuroimage.2018.01.081. Epub 2018 Feb 1.

PMID:
29409999
15.

Facile Synthesis, Geometry, and 2'-Substituent-Dependent in Vivo Activity of 5'-(E)- and 5'-(Z)-Vinylphosphonate-Modified siRNA Conjugates.

Parmar RG, Brown CR, Matsuda S, Willoughby JLS, Theile CS, Charissé K, Foster DJ, Zlatev I, Jadhav V, Maier MA, Egli M, Manoharan M, Rajeev KG.

J Med Chem. 2018 Feb 8;61(3):734-744. doi: 10.1021/acs.jmedchem.7b01147. Epub 2018 Jan 27.

PMID:
29376650
16.

Rhodomyrtone (Rom) is a membrane-active compound.

Saising J, Nguyen MT, Härtner T, Ebner P, Al Mamun Bhuyan A, Berscheid A, Muehlenkamp M, Schäkermann S, Kumari N, Maier ME, Voravuthikunchai SP, Bandow J, Lang F, Brötz-Oesterhelt H, Götz F.

Biochim Biophys Acta Biomembr. 2018 May;1860(5):1114-1124. doi: 10.1016/j.bbamem.2018.01.011. Epub 2018 Jan 6.

17.

Intramolecular Diels-Alder Reactions of Tethered Enoate Substituted Furans Induced by Dialkylaluminum Chloride.

Riedel S, Maichle-Mössmer C, Maier ME.

J Org Chem. 2017 Dec 1;82(23):12798-12805. doi: 10.1021/acs.joc.7b02117. Epub 2017 Nov 13.

PMID:
29111737
18.

Cryptogamic stem covers may contribute to nitrous oxide consumption by mature beech trees.

Machacova K, Maier M, Svobodova K, Lang F, Urban O.

Sci Rep. 2017 Oct 16;7(1):13243. doi: 10.1038/s41598-017-13781-7.

19.

Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression.

Willoughby JLS, Chan A, Sehgal A, Butler JS, Nair JK, Racie T, Shulga-Morskaya S, Nguyen T, Qian K, Yucius K, Charisse K, van Berkel TJC, Manoharan M, Rajeev KG, Maier MA, Jadhav V, Zimmermann TS.

Mol Ther. 2018 Jan 3;26(1):105-114. doi: 10.1016/j.ymthe.2017.08.019. Epub 2017 Sep 7.

20.

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates.

Nair JK, Attarwala H, Sehgal A, Wang Q, Aluri K, Zhang X, Gao M, Liu J, Indrakanti R, Schofield S, Kretschmer P, Brown CR, Gupta S, Willoughby JLS, Boshar JA, Jadhav V, Charisse K, Zimmermann T, Fitzgerald K, Manoharan M, Rajeev KG, Akinc A, Hutabarat R, Maier MA.

Nucleic Acids Res. 2017 Nov 2;45(19):10969-10977. doi: 10.1093/nar/gkx818.

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