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Molecules. 2016 Feb 3;21(2):182. doi: 10.3390/molecules21020182.

Elicitation, an Effective Strategy for the Biotechnological Production of Bioactive High-Added Value Compounds in Plant Cell Factories.

Author information

1
Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Av. Joan XXIII sn, Barcelona 08028, Spain. kems3estrada@gmail.com.
2
Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Av. Joan XXIII sn, Barcelona 08028, Spain. bioraf@hotmail.com.
3
Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Av. Joan XXIII sn, Barcelona 08028, Spain. diegoahmz@hotmail.com.
4
Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Av. Joan XXIII sn, Barcelona 08028, Spain. elisabeth.moyano@upf.edu.
5
Argentina National Rechearch Council (Conicet), Ministry of Science and Technology, Arenales 230. B. Junior, Córdoba X5000APP, Argentina. mgoleniowski@gmail.com.
6
Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Av. Joan XXIII sn, Barcelona 08028, Spain. rcusido@ub.edu.
7
Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Av. Joan XXIII sn, Barcelona 08028, Spain. javierpalazon@ub.edu.

Abstract

Plant in vitro cultures represent an attractive and cost-effective alternative to classical approaches to plant secondary metabolite (PSM) production (the "Plant Cell Factory" concept). Among other advantages, they constitute the only sustainable and eco-friendly system to obtain complex chemical structures biosynthesized by rare or endangered plant species that resist domestication. For successful results, the biotechnological production of PSM requires an optimized system, for which elicitation has proved one of the most effective strategies. In plant cell cultures, an elicitor can be defined as a compound introduced in small concentrations to a living system to promote the biosynthesis of the target metabolite. Traditionally, elicitors have been classified in two types, abiotic or biotic, according to their chemical nature and exogenous or endogenous origin, and notably include yeast extract, methyl jasmonate, salicylic acid, vanadyl sulphate and chitosan. In this review, we summarize the enhancing effects of elicitors on the production of high-added value plant compounds such as taxanes, ginsenosides, aryltetralin lignans and other types of polyphenols, focusing particularly on the use of a new generation of elicitors such as coronatine and cyclodextrins.

KEYWORDS:

elicitors; plant cell factories; plant secondary metabolism; secondary compound production

PMID:
26848649
DOI:
10.3390/molecules21020182
[Indexed for MEDLINE]
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