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Items: 1 to 20 of 42


Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.

National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC.

N Engl J Med. 2019 May 23;380(21):1997-2008. doi: 10.1056/NEJMoa1901686. Epub 2019 May 19.


Plasma Transfusion Products and Contamination with Cellular and Associated Pro-Inflammatory Debris.

Tan YB, Rieske RR, Audia JP, Pastukh VM, Capley GC, Gillespie MN, Smith AA, Tatum DM, Duchesne JC, Kutcher ME, Kerby JD, Simmons JD.

J Am Coll Surg. 2019 Apr 25. pii: S1072-7515(19)30292-3. doi: 10.1016/j.jamcollsurg.2019.04.017. [Epub ahead of print]


Fifty Years of Monocrotaline-Induced Pulmonary Hypertension: What Has It Meant to the Field?

Hill NS, Gillespie MN, McMurtry IF.

Chest. 2017 Dec;152(6):1106-1108. doi: 10.1016/j.chest.2017.10.007. No abstract available.


A novel mtDNA repair fusion protein attenuates maladaptive remodeling and preserves cardiac function in heart failure.

Bradley JM, Li Z, Organ CL, Polhemus DJ, Otsuka H, Islam KN, Bhushan S, Gorodnya OM, Ruchko MV, Gillespie MN, Wilson GL, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2018 Feb 1;314(2):H311-H321. doi: 10.1152/ajpheart.00515.2017. Epub 2017 Nov 3.


Pharmacologic Protection of Mitochondrial DNA Integrity May Afford a New Strategy for Suppressing Lung Ischemia-Reperfusion Injury.

Tan YB, Mulekar S, Gorodnya O, Weyant MJ, Zamora MR, Simmons JD, Machuka T, Gillespie MN.

Ann Am Thorac Soc. 2017 Sep;14(Supplement_3):S210-S215. doi: 10.1513/AnnalsATS.201706-438MG. Review.


Potential contribution of mitochondrial DNA damage associated molecular patterns in transfusion products to the development of acute respiratory distress syndrome after multiple transfusions.

Simmons JD, Lee YL, Pastukh VM, Capley G, Muscat CA, Muscat DC, Marshall ML, Brevard SB, Gillespie MN.

J Trauma Acute Care Surg. 2017 Jun;82(6):1023-1029. doi: 10.1097/TA.0000000000001421.


Mitochondrial DNA Damage Initiates Acute Lung Injury and Multi-Organ System Failure Evoked in Rats by Intra-Tracheal Pseudomonas Aeruginosa.

Lee YL, Obiako B, Gorodnya OM, Ruchko MV, Kuck JL, Pastukh VM, Wilson GL, Simmons JD, Gillespie MN.

Shock. 2017 Jul;48(1):54-60. doi: 10.1097/SHK.0000000000000838.


Mitochondrial DNA damage associated molecular patterns in ventilator-associated pneumonia: Prevention and reversal by intratracheal DNase I.

Simmons JD, Freno DR, Muscat CA, Obiako B, Lee YL, Pastukh VM, Brevard SB, Gillespie MN.

J Trauma Acute Care Surg. 2017 Jan;82(1):120-125. doi: 10.1097/TA.0000000000001269.


Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region.

Pastukh VM, Gorodnya OM, Gillespie MN, Ruchko MV.

Free Radic Biol Med. 2016 Jul;96:78-88. doi: 10.1016/j.freeradbiomed.2016.04.011. Epub 2016 Apr 25.


Evaluation of Microvascular Perfusion and Resuscitation after Severe Injury.

Lee YL, Simmons JD, Gillespie MN, Alvarez DF, Gonzalez RP, Brevard SB, Frotan MA, Schneider AM, Richards WO.

Am Surg. 2015 Dec;81(12):1272-8.


An oxidative DNA "damage" and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression.

Pastukh V, Roberts JT, Clark DW, Bardwell GC, Patel M, Al-Mehdi AB, Borchert GM, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2015 Dec 1;309(11):L1367-75. doi: 10.1152/ajplung.00236.2015. Epub 2015 Oct 2.


Plasma nuclear and mitochondrial DNA levels in acute myocardial infarction patients.

Simmons JD, Gillespie MN.

Coron Artery Dis. 2015 Jun;26(4):286-288. doi: 10.1097/MCA.0000000000000244. No abstract available.


Mitochondrial DNA damage-associated molecular patterns mediate a feed-forward cycle of bacteria-induced vascular injury in perfused rat lungs.

Kuck JL, Obiako BO, Gorodnya OM, Pastukh VM, Kua J, Simmons JD, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1078-85. doi: 10.1152/ajplung.00015.2015. Epub 2015 Mar 20.


Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia/reperfusion.

Yang XM, Cui L, White J, Kuck J, Ruchko MV, Wilson GL, Alexeyev M, Gillespie MN, Downey JM, Cohen MV.

Basic Res Cardiol. 2015 Mar;110(2):3. doi: 10.1007/s00395-014-0459-0. Epub 2015 Jan 17.


Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice.

Hashizume M, Mouner M, Chouteau JM, Gorodnya OM, Ruchko MV, Wilson GL, Gillespie MN, Parker JC.

Pharmaceuticals (Basel). 2014 Aug 22;7(8):894-912. doi: 10.3390/ph7080894.


Blood transfusion products contain mitochondrial DNA damage-associated molecular patterns: a potential effector of transfusion-related acute lung injury.

Lee YL, King MB, Gonzalez RP, Brevard SB, Frotan MA, Gillespie MN, Simmons JD.

J Surg Res. 2014 Oct;191(2):286-9. doi: 10.1016/j.jss.2014.06.003. Epub 2014 Jun 19.


Mitochondria in lung biology and pathology: more than just a powerhouse.

Schumacker PT, Gillespie MN, Nakahira K, Choi AM, Crouser ED, Piantadosi CA, Bhattacharya J.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L962-74. doi: 10.1152/ajplung.00073.2014. Epub 2014 Apr 18. Review.


Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects.

Simmons JD, Lee YL, Mulekar S, Kuck JL, Brevard SB, Gonzalez RP, Gillespie MN, Richards WO.

Ann Surg. 2013 Oct;258(4):591-6; discussion 596-8. doi: 10.1097/SLA.0b013e3182a4ea46.


Mitochondria in hypoxic pulmonary vasoconstriction: potential importance of compartmentalized reactive oxygen species signaling.

Gillespie MN, Al-Mehdi AB, McMurtry IF.

Am J Respir Crit Care Med. 2013 Feb 15;187(4):338-40. doi: 10.1164/rccm.201301-0037ED. No abstract available.


Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice.

Hashizume M, Mouner M, Chouteau JM, Gorodnya OM, Ruchko MV, Potter BJ, Wilson GL, Gillespie MN, Parker JC.

Am J Physiol Lung Cell Mol Physiol. 2013 Feb 15;304(4):L287-97. doi: 10.1152/ajplung.00071.2012. Epub 2012 Dec 14.

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