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Items: 20

1.

Broad-spectrum capture of clinical pathogens using engineered Fc-mannose-binding lectin enhanced by antibiotic treatment.

Seiler BT, Cartwright M, Dinis ALM, Duffy S, Lombardo P, Cartwright D, Super EH, Lanzaro J, Dugas K, Super M, Ingber DE.

F1000Res. 2019 Jan 25;8:108. doi: 10.12688/f1000research.17447.1. eCollection 2019.

2.

Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites.

Tovaglieri A, Sontheimer-Phelps A, Geirnaert A, Prantil-Baun R, Camacho DM, Chou DB, Jalili-Firoozinezhad S, de Wouters T, Kasendra M, Super M, Cartwright MJ, Richmond CA, Breault DT, Lacroix C, Ingber DE.

Microbiome. 2019 Mar 20;7(1):43. doi: 10.1186/s40168-019-0650-5.

3.

Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions.

Yu W, Tong L, Selyutin O, Chen L, Hu B, Zhong B, Hao J, Ji T, Zan S, Yin J, Ruck RT, Curry S, McMonagle P, Agrawal S, Rokosz L, Carr D, Ingravallo P, Bystol K, Lahser F, Liu R, Chen S, Feng KI, Cartwright M, Asante-Appiah E, Kozlowski JA.

J Med Chem. 2018 May 10;61(9):3984-4003. doi: 10.1021/acs.jmedchem.7b01927. Epub 2018 May 1.

PMID:
29681153
4.

Analyzing the Potential Root Causes of Variability of Pharmacokinetics in Preclinical Species.

Daublain P, Feng KI, Altman MD, Martin I, Mukherjee S, Nofsinger R, Northrup AB, Tschirret-Guth R, Cartwright M, McGregor C.

Mol Pharm. 2017 May 1;14(5):1634-1645. doi: 10.1021/acs.molpharmaceut.6b01118. Epub 2017 Apr 3.

PMID:
28329443
5.

Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms.

Tong L, Yu W, Chen L, Selyutin O, Dwyer MP, Nair AG, Mazzola R, Kim JH, Sha D, Yin J, Ruck RT, Davies IW, Hu B, Zhong B, Hao J, Ji T, Zan S, Liu R, Agrawal S, Xia E, Curry S, McMonagle P, Bystol K, Lahser F, Carr D, Rokosz L, Ingravallo P, Chen S, Feng KI, Cartwright M, Asante-Appiah E, Kozlowski JA.

J Med Chem. 2017 Jan 12;60(1):290-306. doi: 10.1021/acs.jmedchem.6b01310. Epub 2016 Nov 15.

6.

A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood.

Cartwright M, Rottman M, Shapiro NI, Seiler B, Lombardo P, Gamini N, Tomolonis J, Watters AL, Waterhouse A, Leslie D, Bolgen D, Graveline A, Kang JH, Didar T, Dimitrakakis N, Cartwright D, Super M, Ingber DE.

EBioMedicine. 2016 Jul;9:217-227. doi: 10.1016/j.ebiom.2016.06.014. Epub 2016 Jun 13.

7.

Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.

Neelamkavil SF, Agrawal S, Bara T, Bennett C, Bhat S, Biswas D, Brockunier L, Buist N, Burnette D, Cartwright M, Chackalamannil S, Chase R, Chelliah M, Chen A, Clasby M, Colandrea VJ, Davies IW, Eagen K, Guo Z, Han Y, Howe J, Jayne C, Josien H, Kargman S, Marcantonio K, Miao S, Miller R, Nolting A, Pinto P, Rajagopalan M, Ruck RT, Shah U, Soriano A, Sperbeck D, Velazquez F, Wu J, Xia Y, Venkatraman S.

ACS Med Chem Lett. 2015 Dec 22;7(1):111-6. doi: 10.1021/acsmedchemlett.5b00425. eCollection 2016 Jan 14.

8.

Improved treatment of systemic blood infections using antibiotics with extracorporeal opsonin hemoadsorption.

Didar TF, Cartwright MJ, Rottman M, Graveline AR, Gamini N, Watters AL, Leslie DC, Mammoto T, Rodas MJ, Kang JH, Waterhouse A, Seiler BT, Lombardo P, Qendro EI, Super M, Ingber DE.

Biomaterials. 2015 Oct;67:382-92. doi: 10.1016/j.biomaterials.2015.07.046. Epub 2015 Jul 26.

PMID:
26253638
9.

An extracorporeal blood-cleansing device for sepsis therapy.

Kang JH, Super M, Yung CW, Cooper RM, Domansky K, Graveline AR, Mammoto T, Berthet JB, Tobin H, Cartwright MJ, Watters AL, Rottman M, Waterhouse A, Mammoto A, Gamini N, Rodas MJ, Kole A, Jiang A, Valentin TM, Diaz A, Takahashi K, Ingber DE.

Nat Med. 2014 Oct;20(10):1211-6. doi: 10.1038/nm.3640. Epub 2014 Sep 14.

PMID:
25216635
10.

Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1).

Deng Y, Yang Z, Shipps GW Jr, Lo SM, West R, Hwa J, Zheng S, Farley C, Lachowicz J, van Heek M, Bass AS, Sinha DP, Mahon CR, Cartwright ME.

Bioorg Med Chem Lett. 2013 Feb 1;23(3):791-6. doi: 10.1016/j.bmcl.2012.11.075. Epub 2012 Dec 5.

PMID:
23265904
11.

Progressing preclinical drug candidates: strategies on preclinical safety studies and the quest for adequate exposure.

Higgins J, Cartwright ME, Templeton AC.

Drug Discov Today. 2012 Aug;17(15-16):828-36. doi: 10.1016/j.drudis.2012.03.016. Epub 2012 Apr 11. Review.

PMID:
22546604
12.

Aging, depot origin, and preadipocyte gene expression.

Cartwright MJ, Schlauch K, Lenburg ME, Tchkonia T, Pirtskhalava T, Cartwright A, Thomou T, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2010 Mar;65(3):242-51. doi: 10.1093/gerona/glp213. Epub 2010 Jan 27.

13.

Phospholipidosis in neurons caused by posaconazole, without evidence for functional neurologic effects.

Cartwright ME, Petruska J, Arezzo J, Frank D, Litwak M, Morrissey RE, MacDonald J, Davis TE.

Toxicol Pathol. 2009 Dec;37(7):902-10. doi: 10.1177/0192623309348521.

PMID:
19833913
14.

Exploratory drug safety: a discovery strategy to reduce attrition in development.

Bass AS, Cartwright ME, Mahon C, Morrison R, Snyder R, McNamara P, Bradley P, Zhou YY, Hunter J.

J Pharmacol Toxicol Methods. 2009 Jul-Aug;60(1):69-78. doi: 10.1016/j.vascn.2009.04.194. Epub 2009 May 5. Review.

PMID:
19422924
15.

Increased TNFalpha and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis.

Tchkonia T, Pirtskhalava T, Thomou T, Cartwright MJ, Wise B, Karagiannides I, Shpilman A, Lash TL, Becherer JD, Kirkland JL.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1810-9. Epub 2007 Oct 2.

16.

SCH 412499: biodistribution and safety of an adenovirus containing P21(WAF-1/CIP-1) following subconjunctival injection in Cynomolgus monkeys.

Veneziale RW, Bral CM, Sinha DP, Watkins RW, Cartwright ME, Rosenblum IY, Treinen KA, Kishnani NS, Nelson J, Chen Z, Faha B, Maneval D, Munger RJ, Cai XY, Cullen C, Arezzo JC.

Cutan Ocul Toxicol. 2007;26(2):83-105.

PMID:
17612977
17.

Aging in adipocytes: potential impact of inherent, depot-specific mechanisms.

Cartwright MJ, Tchkonia T, Kirkland JL.

Exp Gerontol. 2007 Jun;42(6):463-71. Epub 2007 Mar 25. Review.

18.

Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns.

Tchkonia T, Lenburg M, Thomou T, Giorgadze N, Frampton G, Pirtskhalava T, Cartwright A, Cartwright M, Flanagan J, Karagiannides I, Gerry N, Forse RA, Tchoukalova Y, Jensen MD, Pothoulakis C, Kirkland JL.

Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E298-307. Epub 2006 Sep 19.

19.

Incidental mononuclear cell infiltrate in the uvea of cynomolgus monkeys.

Sinha DP, Cartwright ME, Johnson RC.

Toxicol Pathol. 2006;34(2):148-51.

PMID:
16537293
20.

Pharmacological characterization of postjunctional alpha-adrenoceptors in human nasal mucosa.

Corboz MR, Rivelli MA, Varty L, Mutter J, Cartwright M, Rizzo CA, Eckel SP, Anthes JC, Hey JA.

Am J Rhinol. 2005 Sep-Oct;19(5):495-502.

PMID:
16270605

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