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Items: 1 to 20 of 31


Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections.

Nelemans T, Kikkert M.

Viruses. 2019 Oct 18;11(10). pii: E961. doi: 10.3390/v11100961. Review.


Innate Immune Evasion by Human Respiratory RNA Viruses.

Kikkert M.

J Innate Immun. 2019 Oct 14:1-17. doi: 10.1159/000503030. [Epub ahead of print] Review.


Profiling DUBs and Ubl-specific proteases with activity-based probes.

Geurink PP, van der Heden van Noort GJ, Mulder MPC, Knaap RCM, Kikkert M, Ovaa H.

Methods Enzymol. 2019;618:357-387. doi: 10.1016/bs.mie.2018.12.037. Epub 2019 Feb 14.


Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication.

Oudshoorn D, Rijs K, Limpens RWAL, Groen K, Koster AJ, Snijder EJ, Kikkert M, Bárcena M.

MBio. 2017 Nov 21;8(6). pii: e01658-17. doi: 10.1128/mBio.01658-17.


Interaction of the innate immune system with positive-strand RNA virus replication organelles.

Scutigliani EM, Kikkert M.

Cytokine Growth Factor Rev. 2017 Oct;37:17-27. doi: 10.1016/j.cytogfr.2017.05.007. Epub 2017 Jun 27.


Host Factors in Coronavirus Replication.

de Wilde AH, Snijder EJ, Kikkert M, van Hemert MJ.

Curr Top Microbiol Immunol. 2018;419:1-42. doi: 10.1007/82_2017_25. Review.


Structure and Function of Viral Deubiquitinating Enzymes.

Bailey-Elkin BA, Knaap RCM, Kikkert M, Mark BL.

J Mol Biol. 2017 Nov 10;429(22):3441-3470. doi: 10.1016/j.jmb.2017.06.010. Epub 2017 Jun 16. Review.


Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.

Zhang W, Bailey-Elkin BA, Knaap RCM, Khare B, Dalebout TJ, Johnson GG, van Kasteren PB, McLeish NJ, Gu J, He W, Kikkert M, Mark BL, Sidhu SS.

PLoS Pathog. 2017 May 18;13(5):e1006372. doi: 10.1371/journal.ppat.1006372. eCollection 2017 May.


Antiviral Innate Immune Response Interferes with the Formation of Replication-Associated Membrane Structures Induced by a Positive-Strand RNA Virus.

Oudshoorn D, van der Hoeven B, Limpens RW, Beugeling C, Snijder EJ, Bárcena M, Kikkert M.

MBio. 2016 Dec 6;7(6). pii: e01991-16. doi: 10.1128/mBio.01991-16.


Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses.

Rabouw HH, Langereis MA, Knaap RC, Dalebout TJ, Canton J, Sola I, Enjuanes L, Bredenbeek PJ, Kikkert M, de Groot RJ, van Kuppeveld FJ.

PLoS Pathog. 2016 Oct 26;12(10):e1005982. doi: 10.1371/journal.ppat.1005982. eCollection 2016 Oct.


Biogenesis and architecture of arterivirus replication organelles.

van der Hoeven B, Oudshoorn D, Koster AJ, Snijder EJ, Kikkert M, Bárcena M.

Virus Res. 2016 Jul 15;220:70-90. doi: 10.1016/j.virusres.2016.04.001. Epub 2016 Apr 9. Review.


A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins.

de Wilde AH, Wannee KF, Scholte FE, Goeman JJ, Ten Dijke P, Snijder EJ, Kikkert M, van Hemert MJ.

J Virol. 2015 Aug;89(16):8318-33. doi: 10.1128/JVI.01029-15. Epub 2015 Jun 3.


In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2.

van Kasteren PB, Knaap RC, van den Elzen P, Snijder EJ, Balasuriya UB, van den Born E, Kikkert M.

Vet Microbiol. 2015 Jul 9;178(1-2):132-7. doi: 10.1016/j.vetmic.2015.04.018. Epub 2015 Apr 30.


Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression.

Bailey-Elkin BA, Knaap RC, Johnson GG, Dalebout TJ, Ninaber DK, van Kasteren PB, Bredenbeek PJ, Snijder EJ, Kikkert M, Mark BL.

J Biol Chem. 2014 Dec 12;289(50):34667-82. doi: 10.1074/jbc.M114.609644. Epub 2014 Oct 15.


Viral OTU deubiquitinases: a structural and functional comparison.

Bailey-Elkin BA, van Kasteren PB, Snijder EJ, Kikkert M, Mark BL.

PLoS Pathog. 2014 Mar 27;10(3):e1003894. doi: 10.1371/journal.ppat.1003894. eCollection 2014 Mar. Review.


Arterivirus molecular biology and pathogenesis.

Snijder EJ, Kikkert M, Fang Y.

J Gen Virol. 2013 Oct;94(Pt 10):2141-63. doi: 10.1099/vir.0.056341-0. Epub 2013 Aug 12. Review.


Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells.

van Kasteren PB, Bailey-Elkin BA, James TW, Ninaber DK, Beugeling C, Khajehpour M, Snijder EJ, Mark BL, Kikkert M.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):E838-47. doi: 10.1073/pnas.1218464110. Epub 2013 Feb 11.


Regulation of the innate immune system by ubiquitin and ubiquitin-like modifiers.

Oudshoorn D, Versteeg GA, Kikkert M.

Cytokine Growth Factor Rev. 2012 Dec;23(6):273-82. doi: 10.1016/j.cytogfr.2012.08.003. Epub 2012 Sep 8. Review.


Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex.

Belgnaoui SM, Paz S, Samuel S, Goulet ML, Sun Q, Kikkert M, Iwai K, Dikic I, Hiscott J, Lin R.

Cell Host Microbe. 2012 Aug 16;12(2):211-22. doi: 10.1016/j.chom.2012.06.009.


Arterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling.

van Kasteren PB, Beugeling C, Ninaber DK, Frias-Staheli N, van Boheemen S, García-Sastre A, Snijder EJ, Kikkert M.

J Virol. 2012 Jan;86(2):773-85. doi: 10.1128/JVI.06277-11. Epub 2011 Nov 9.

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