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Items: 1 to 20 of 29

1.

A Short Peptide Inhibitor as an Activity-Based Probe for Matriptase-2.

Mangold M, Gütschow M, Stirnberg M.

Pharmaceuticals (Basel). 2018 May 21;11(2). pii: E49. doi: 10.3390/ph11020049.

2.

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.

Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C.

Cell Rep. 2017 Nov 21;21(8):2090-2103. doi: 10.1016/j.celrep.2017.10.087.

3.

Design and chemical syntheses of potent matriptase-2 inhibitors based on trypsin inhibitor SFTI-1 isolated from sunflower seeds.

Gitlin-Domagalska A, Dębowski D, Łęgowska A, Stirnberg M, Okońska J, Gütschow M, Rolka K.

Biopolymers. 2017 Nov;108(6). doi: 10.1002/bip.23031.

PMID:
28555756
4.

A Fluorescent-Labeled Phosphono Bisbenzguanidine As an Activity-Based Probe for Matriptase.

Häußler D, Schulz-Fincke AC, Beckmann AM, Keils A, Gilberg E, Mangold M, Bajorath J, Stirnberg M, Steinmetzer T, Gütschow M.

Chemistry. 2017 Apr 19;23(22):5205-5209. doi: 10.1002/chem.201700319. Epub 2017 Mar 28.

PMID:
28370501
5.

Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.

Bedau T, Peters F, Prox J, Arnold P, Schmidt F, Finkernagel M, Köllmann S, Wichert R, Otte A, Ohler A, Stirnberg M, Lucius R, Koudelka T, Tholey A, Biasin V, Pietrzik CU, Kwapiszewska G, Becker-Pauly C.

FASEB J. 2017 Mar;31(3):1226-1237. doi: 10.1096/fj.201601113R. Epub 2016 Dec 21.

PMID:
28003343
6.

Evaluation of bisbenzamidines as inhibitors for matriptase-2.

Beckmann AM, Gilberg E, Gattner S, Huang TL, Vanden Eynde JJ, Mayence A, Bajorath J, Stirnberg M, Gütschow M.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3741-5. doi: 10.1016/j.bmcl.2016.05.071. Epub 2016 May 26.

PMID:
27287367
7.

Phosphono Bisbenzguanidines as Irreversible Dipeptidomimetic Inhibitors and Activity-Based Probes of Matriptase-2.

Häußler D, Mangold M, Furtmann N, Braune A, Blaut M, Bajorath J, Stirnberg M, Gütschow M.

Chemistry. 2016 Jun 13;22(25):8525-35. doi: 10.1002/chem.201600206. Epub 2016 May 23.

PMID:
27214780
8.

The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2.

Beckmann AM, Glebov K, Walter J, Merkel O, Mangold M, Schmidt F, Becker-Pauly C, Gütschow M, Stirnberg M.

Biol Chem. 2016 Aug 1;397(8):777-90. doi: 10.1515/hsz-2015-0263.

PMID:
27078672
9.

3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach.

Roydeva PG, Beckmann AM, Stirnberg M, Cesar J, Kikelj D, Ilaš J, Gütschow M.

Pharmaceuticals (Basel). 2016 Jan 13;9(1). pii: E2. doi: 10.3390/ph9010002.

10.

En Route to New Therapeutic Options for Iron Overload Diseases: Matriptase-2 as a Target for Kunitz-Type Inhibitors.

Beckmann AM, Maurer E, Lülsdorff V, Wilms A, Furtmann N, Bajorath J, Gütschow M, Stirnberg M.

Chembiochem. 2016 Apr 1;17(7):595-604. doi: 10.1002/cbic.201500651. Epub 2016 Feb 16.

PMID:
26762582
11.

Limiting the Number of Potential Binding Modes by Introducing Symmetry into Ligands: Structure-Based Design of Inhibitors for Trypsin-Like Serine Proteases.

Furtmann N, Häußler D, Scheidt T, Stirnberg M, Steinmetzer T, Bajorath J, Gütschow M.

Chemistry. 2016 Jan 11;22(2):610-25. doi: 10.1002/chem.201503534. Epub 2015 Dec 2.

PMID:
26625703
12.

Design, characterization and cellular uptake studies of fluorescence-labeled prototypic cathepsin inhibitors.

Kohl F, Schmitz J, Furtmann N, Schulz-Fincke AC, Mertens MD, Küppers J, Benkhoff M, Tobiasch E, Bartz U, Bajorath J, Stirnberg M, Gütschow M.

Org Biomol Chem. 2015 Nov 7;13(41):10310-23. doi: 10.1039/c5ob01613d.

PMID:
26307943
13.

A Bisbenzamidine Phosphonate as a Janus-faced Inhibitor for Trypsin-like Serine Proteases.

Häußler D, Scheidt T, Stirnberg M, Steinmetzer T, Gütschow M.

ChemMedChem. 2015 Oct;10(10):1641-6. doi: 10.1002/cmdc.201500319. Epub 2015 Aug 25.

PMID:
26306030
14.

Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.

Jäckle F, Schmidt F, Wichert R, Arnold P, Prox J, Mangold M, Ohler A, Pietrzik CU, Koudelka T, Tholey A, Gütschow M, Stirnberg M, Becker-Pauly C.

Biochem J. 2015 Aug 15;470(1):91-103. doi: 10.1042/BJ20141417. Epub 2015 Jun 15.

PMID:
26251449
15.

Inhibitors of Matriptase-2 Based on the Trypsin Inhibitor SFTI-1.

Gitlin A, Dębowski D, Karna N, Łęgowska A, Stirnberg M, Gütschow M, Rolka K.

Chembiochem. 2015 Jul 27;16(11):1601-7. doi: 10.1002/cbic.201500200. Epub 2015 Jun 19.

PMID:
25999208
16.

Cell surface serine protease matriptase-2 suppresses fetuin-A/AHSG-mediated induction of hepcidin.

Stirnberg M, Maurer E, Arenz K, Babler A, Jahnen-Dechent W, Gütschow M.

Biol Chem. 2015 Jan;396(1):81-93. doi: 10.1515/hsz-2014-0120.

PMID:
25205713
17.

Chemical introduction of the green fluorescence: imaging of cysteine cathepsins by an irreversibly locked GFP fluorophore.

Frizler M, Yampolsky IV, Baranov MS, Stirnberg M, Gütschow M.

Org Biomol Chem. 2013 Sep 21;11(35):5913-21. doi: 10.1039/c3ob41341a.

PMID:
23912233
18.

Hepatocyte growth factor activator inhibitor type 2 (HAI-2) modulates hepcidin expression by inhibiting the cell surface protease matriptase-2.

Maurer E, Gütschow M, Stirnberg M.

Biochem J. 2013 Mar 15;450(3):583-93. doi: 10.1042/BJ20121518.

PMID:
23293962
19.

Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines.

Dosa S, Stirnberg M, Lülsdorff V, Häußler D, Maurer E, Gütschow M.

Bioorg Med Chem. 2012 Nov 1;20(21):6489-505. doi: 10.1016/j.bmc.2012.08.042. Epub 2012 Sep 5.

PMID:
23026080
20.

Matriptase-2, a regulatory protease of iron homeostasis: possible substrates, cleavage sites and inhibitors.

Stirnberg M, Gütschow M.

Curr Pharm Des. 2013;19(6):1052-61. Review.

PMID:
23016685

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