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Items: 1 to 20 of 47


The PCNA interaction motifs revisited: thinking outside the PIP-box.

Prestel A, Wichmann N, Martins JM, Marabini R, Kassem N, Broendum SS, Otterlei M, Nielsen O, Willemoës M, Ploug M, Boomsma W, Kragelund BB.

Cell Mol Life Sci. 2019 May 27. doi: 10.1007/s00018-019-03150-0. [Epub ahead of print]


APIM-Mediated REV3L⁻PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells.

Ræder SB, Nepal A, Bjørås KØ, Seelinger M, Kolve RS, Nedal A, Müller R, Otterlei M.

Int J Mol Sci. 2018 Dec 28;20(1). pii: E100. doi: 10.3390/ijms20010100.


"Two hits - one stone"; increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling.

Søgaard CK, Blindheim A, Røst LM, Petrović V, Nepal A, Bachke S, Liabakk NB, Gederaas OA, Viset T, Arum CJ, Bruheim P, Otterlei M.

Oncotarget. 2018 Aug 21;9(65):32448-32465. doi: 10.18632/oncotarget.25963. eCollection 2018 Aug 21.


The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans.

Olaisen C, Kvitvang HFN, Lee S, Almaas E, Bruheim P, Drabløs F, Otterlei M.

FEBS Open Bio. 2018 May 31;8(7):1135-1145. doi: 10.1002/2211-5463.12442. eCollection 2018 Jul.


Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress.

Petrovic V, Nepal A, Olaisen C, Bachke S, Hira J, Søgaard CK, Røst LM, Misund K, Andreassen T, Melø TM, Bartsova Z, Bruheim P, Otterlei M.

Nutrients. 2018 Apr 5;10(4). pii: E450. doi: 10.3390/nu10040450.


APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer.

Søgaard CK, Moestue SA, Rye MB, Kim J, Nepal A, Liabakk NB, Bachke S, Bathen TF, Otterlei M, Hill DK.

Oncotarget. 2018 Jan 27;9(14):11752-11766. doi: 10.18632/oncotarget.24357. eCollection 2018 Feb 20.


p38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage.

de Sousa MML, Bjørås KØ, Hanssen-Bauer A, Solvang-Garten K, Otterlei M.

Sci Rep. 2017 Jul 24;7(1):6322. doi: 10.1038/s41598-017-06770-3.


Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.

Bj Rås KØ, Sousa MML, Sharma A, Fonseca DM, S Gaard CK, Bj Rås M, Otterlei M.

Nucleic Acids Res. 2017 Aug 21;45(14):8291-8301. doi: 10.1093/nar/gkx476.


Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel.

Petrovic V, Olaisen C, Sharma A, Nepal A, Bugge S, Sundby E, Hoff BH, Slupphaug G, Otterlei M.

Data Brief. 2017 Mar 18;12:18-21. doi: 10.1016/j.dib.2017.03.023. eCollection 2017 Jun.


On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay.

Petrovic V, Olaisen C, Sharma A, Nepal A, Bugge S, Sundby E, Hoff BH, Slupphaug G, Otterlei M.

Anal Biochem. 2017 Apr 15;523:10-16. doi: 10.1016/j.ab.2017.01.027. Epub 2017 Feb 3.


A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis.

Marstad A, Landsverk OJ, Strømme O, Otterlei M, Collas P, Sundan A, Brede G.

FEBS J. 2016 Feb;283(4):757-70. doi: 10.1111/febs.13630. Epub 2016 Jan 16.


PCNA-interacting peptides reduce Akt phosphorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling.

Olaisen C, Müller R, Nedal A, Otterlei M.

Cell Signal. 2015 Jul;27(7):1478-87. doi: 10.1016/j.cellsig.2015.03.009. Epub 2015 Mar 20.


Increased Anticancer Efficacy of Intravesical Mitomycin C Therapy when Combined with a PCNA Targeting Peptide.

Gederaas OA, Søgaard CD, Viset T, Bachke S, Bruheim P, Arum CJ, Otterlei M.

Transl Oncol. 2014 Dec;7(6):812-23. doi: 10.1016/j.tranon.2014.10.005.


Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization.

Baglo Y, Hagen L, Høgset A, Drabløs F, Otterlei M, Gederaas OA.

Biomed Res Int. 2014;2014:921296. doi: 10.1155/2014/921296. Epub 2014 Jun 30.


Targeting proliferating cell nuclear antigen and its protein interactions induces apoptosis in multiple myeloma cells.

Müller R, Misund K, Holien T, Bachke S, Gilljam KM, Våtsveen TK, Rø TB, Bellacchio E, Sundan A, Otterlei M.

PLoS One. 2013 Jul 31;8(7):e70430. doi: 10.1371/journal.pone.0070430. Print 2013.


X-ray repair cross complementing protein 1 in base excision repair.

Hanssen-Bauer A, Solvang-Garten K, Akbari M, Otterlei M.

Int J Mol Sci. 2012 Dec 17;13(12):17210-29. doi: 10.3390/ijms131217210. Review.


Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase.

Hegre SA, Sætrom P, Aas PA, Pettersen HS, Otterlei M, Krokan HE.

DNA Repair (Amst). 2013 Jan 1;12(1):80-6. doi: 10.1016/j.dnarep.2012.10.007. Epub 2012 Dec 8.


Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA.

Gilljam KM, Müller R, Liabakk NB, Otterlei M.

PLoS One. 2012;7(11):e49199. doi: 10.1371/journal.pone.0049199. Epub 2012 Nov 13.


Human ALKBH4 interacts with proteins associated with transcription.

Bjørnstad LG, Meza TJ, Otterlei M, Olafsrud SM, Meza-Zepeda LA, Falnes PØ.

PLoS One. 2012;7(11):e49045. doi: 10.1371/journal.pone.0049045. Epub 2012 Nov 8.


The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.

Torseth K, Doseth B, Hagen L, Olaisen C, Liabakk NB, Græsmann H, Durandy A, Otterlei M, Krokan HE, Kavli B, Slupphaug G.

DNA Repair (Amst). 2012 Jun 1;11(6):559-69. doi: 10.1016/j.dnarep.2012.03.006. Epub 2012 Apr 20.


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