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Items: 1 to 20 of 22


Vimentin expression is retained in erythroid cells differentiated from human iPSC and ESC and indicates dysregulation in these cells early in differentiation.

Trakarnsanga K, Ferguson D, Daniels DE, Griffiths RE, Wilson MC, Mordue KE, Gartner A, Andrienko TN, Calvert A, Condie A, McCahill A, Mountford JC, Toye AM, Anstee DJ, Frayne J.

Stem Cell Res Ther. 2019 Apr 29;10(1):130. doi: 10.1186/s13287-019-1231-z.


Bicuspid Aortic Valve Alters Aortic Protein Expression Profile in Neonatal Coarctation Patients.

Skeffington KL, Bond AR, Abdul-Ghani S, Iacobazzi D, Kang SL, Heesom KJ, Wilson MC, Ghorbel M, Stoica S, Martin R, Suleiman MS, Caputo M.

J Clin Med. 2019 Apr 16;8(4). pii: E517. doi: 10.3390/jcm8040517.


LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells.

Morgan RG, Ridsdale J, Payne M, Heesom KJ, Wilson MC, Davidson A, Greenhough A, Davies S, Williams AC, Blair A, Waterman ML, Tonks A, Darley RL.

Haematologica. 2019 Jan 10. pii: haematol.2018.202846. doi: 10.3324/haematol.2018.202846. [Epub ahead of print]


Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing.

Hawksworth J, Satchwell TJ, Meinders M, Daniels DE, Regan F, Thornton NM, Wilson MC, Dobbe JG, Streekstra GJ, Trakarnsanga K, Heesom KJ, Anstee DJ, Frayne J, Toye AM.

EMBO Mol Med. 2018 Jun;10(6). pii: e8454. doi: 10.15252/emmm.201708454.


Secretory factors from OP9 stromal cells delay differentiation and increase the expansion potential of adult erythroid cells in vitro.

Trakarnsanga K, Wilson MC, Heesom KJ, Andrienko TN, Srisawat C, Frayne J.

Sci Rep. 2018 Jan 31;8(1):1983. doi: 10.1038/s41598-018-20491-1.


Quantitative proteomics of plasma vesicles identify novel biomarkers for hemoglobin E/β-thalassemic patients.

Kittivorapart J, Crew VK, Wilson MC, Heesom KJ, Siritanaratkul N, Toye AM.

Blood Adv. 2018 Jan 23;2(2):95-104. doi: 10.1182/bloodadvances.2017011726.


An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells.

Trakarnsanga K, Griffiths RE, Wilson MC, Blair A, Satchwell TJ, Meinders M, Cogan N, Kupzig S, Kurita R, Nakamura Y, Toye AM, Anstee DJ, Frayne J.

Nat Commun. 2017 Mar 14;8:14750. doi: 10.1038/ncomms14750.


Comparison of the Proteome of Adult and Cord Erythroid Cells, and Changes in the Proteome Following Reticulocyte Maturation.

Wilson MC, Trakarnsanga K, Heesom KJ, Cogan N, Green C, Toye AM, Parsons SF, Anstee DJ, Frayne J.

Mol Cell Proteomics. 2016 Jun;15(6):1938-46. doi: 10.1074/mcp.M115.057315. Epub 2016 Mar 22.


Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton.

Zuccala ES, Satchwell TJ, Angrisano F, Tan YH, Wilson MC, Heesom KJ, Baum J.

Sci Rep. 2016 Feb 2;6:19766. doi: 10.1038/srep19766.


Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL.

Trakarnsanga K, Wilson MC, Lau W, Singleton BK, Parsons SF, Sakuntanaga P, Kurita R, Nakamura Y, Anstee DJ, Frayne J.

Haematologica. 2014 Nov;99(11):1677-85. doi: 10.3324/haematol.2014.110155. Epub 2014 Aug 8.


Qualitative and quantitative comparison of the proteome of erythroid cells differentiated from human iPSCs and adult erythroid cells by multiplex TMT labelling and nanoLC-MS/MS.

Trakarnsanga K, Wilson MC, Griffiths RE, Toye AM, Carpenter L, Heesom KJ, Parsons SF, Anstee DJ, Frayne J.

PLoS One. 2014 Jul 14;9(7):e100874. doi: 10.1371/journal.pone.0100874. eCollection 2014.


The neuroplastin adhesion molecules are accessory proteins that chaperone the monocarboxylate transporter MCT2 to the neuronal cell surface.

Wilson MC, Kraus M, Marzban H, Sarna JR, Wang Y, Hawkes R, Halestrap AP, Beesley PW.

PLoS One. 2013 Nov 18;8(11):e78654. doi: 10.1371/journal.pone.0078654. eCollection 2013.


The monocarboxylate transporter family--role and regulation.

Halestrap AP, Wilson MC.

IUBMB Life. 2012 Feb;64(2):109-19. doi: 10.1002/iub.572. Epub 2011 Dec 9. Review.


Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes.

Singleton BK, Lau W, Fairweather VS, Burton NM, Wilson MC, Parsons SF, Richardson BM, Trakarnsanga K, Brady RL, Anstee DJ, Frayne J.

Blood. 2011 Sep 15;118(11):3137-45. doi: 10.1182/blood-2011-04-349985. Epub 2011 Jul 21.


Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans.

Mouchiroud L, Molin L, Kasturi P, Triba MN, Dumas ME, Wilson MC, Halestrap AP, Roussel D, Masse I, Dallière N, Ségalat L, Billaud M, Solari F.

Aging Cell. 2011 Feb;10(1):39-54. doi: 10.1111/j.1474-9726.2010.00640.x. Epub 2010 Nov 15.


The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein.

Ovens MJ, Manoharan C, Wilson MC, Murray CM, Halestrap AP.

Biochem J. 2010 Oct 15;431(2):217-25. doi: 10.1042/BJ20100890.


AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.

Ovens MJ, Davies AJ, Wilson MC, Murray CM, Halestrap AP.

Biochem J. 2010 Jan 15;425(3):523-30. doi: 10.1042/BJ20091515.


Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle.

Wilson MC, Meredith D, Bunnun C, Sessions RB, Halestrap AP.

J Biol Chem. 2009 Jul 24;284(30):20011-21. doi: 10.1074/jbc.M109.014217. Epub 2009 May 27.


A novel role for embigin to promote sprouting of motor nerve terminals at the neuromuscular junction.

Lain E, Carnejac S, Escher P, Wilson MC, Lømo T, Gajendran N, Brenner HR.

J Biol Chem. 2009 Mar 27;284(13):8930-9. doi: 10.1074/jbc.M809491200. Epub 2009 Jan 21.

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