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Items: 1 to 20 of 32

1.

Discovery of Kynurenines Containing Oligopeptides as Potent Opioid Receptor Agonists.

Szűcs E, Stefanucci A, Dimmito MP, Zádor F, Pieretti S, Zengin G, Vécsei L, Benyhe S, Nalli M, Mollica A.

Biomolecules. 2020 Feb 12;10(2). pii: E284. doi: 10.3390/biom10020284.

2.

Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies.

Puxeddu M, Shen H, Bai R, Coluccia A, Nalli M, Mazzoccoli C, Da Pozzo E, Cavallini C, Martini C, Orlando V, Biagioni S, Mazzoni C, Coluccia AML, Hamel E, Liu T, Silvestri R, La Regina G.

Eur J Med Chem. 2020 Jan 1;185:111828. doi: 10.1016/j.ejmech.2019.111828. Epub 2019 Nov 2.

PMID:
31727471
3.

Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents.

Coluccia A, La Regina G, Naccarato V, Nalli M, Orlando V, Biagioni S, De Angelis ML, Baiocchi M, Gautier C, Gianni S, Di Pastena F, Di Magno L, Canettieri G, Coluccia AML, Silvestri R.

ACS Med Chem Lett. 2019 Jan 14;10(4):499-503. doi: 10.1021/acsmedchemlett.8b00532. eCollection 2019 Apr 11.

4.

New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.

La Regina G, Bai R, Coluccia A, Naccarato V, Famiglini V, Nalli M, Masci D, Verrico A, Rovella P, Mazzoccoli C, Da Pozzo E, Cavallini C, Martini C, Vultaggio S, Dondio G, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R.

Eur J Med Chem. 2018 May 25;152:283-297. doi: 10.1016/j.ejmech.2018.04.042. Epub 2018 Apr 25.

PMID:
29730191
5.

Effects of curcumin and curcumin analogues on TRP channels.

Nalli M, Ortar G, Schiano Moriello A, Di Marzo V, De Petrocellis L.

Fitoterapia. 2017 Oct;122:126-131. doi: 10.1016/j.fitote.2017.09.007. Epub 2017 Sep 10. Review.

PMID:
28903060
6.

3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin.

La Regina G, Bai R, Coluccia A, Famiglini V, Passacantilli S, Naccarato V, Ortar G, Mazzoccoli C, Ruggieri V, Agriesti F, Piccoli C, Tataranni T, Nalli M, Brancale A, Vultaggio S, Mercurio C, Varasi M, Saponaro C, Sergio S, Maffia M, Coluccia AML, Hamel E, Silvestri R.

ACS Med Chem Lett. 2017 Apr 26;8(5):521-526. doi: 10.1021/acsmedchemlett.7b00022. eCollection 2017 May 11.

7.

Arylboronic acids as dual-action FAAH and TRPV1 ligands.

Morera E, Di Marzo V, Monti L, Allarà M, Schiano Moriello A, Nalli M, Ortar G, De Petrocellis L.

Bioorg Med Chem Lett. 2016 Mar 1;26(5):1401-5. doi: 10.1016/j.bmcl.2016.01.071. Epub 2016 Jan 25.

PMID:
26850005
8.

TRPA1 channels as targets for resveratrol and related stilbenoids.

Nalli M, Ortar G, Moriello AS, Morera E, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):899-902. doi: 10.1016/j.bmcl.2015.12.065. Epub 2015 Dec 19.

PMID:
26750258
9.

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.

La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Verrico A, Miele A, Monti L, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Ricci B, Soriani A, Santoni A, Caraglia M, Porto S, Da Pozzo E, Martini C, Brancale A, Marinelli L, Novellino E, Vultaggio S, Varasi M, Mercurio C, Bigogno C, Dondio G, Hamel E, Lavia P, Silvestri R.

J Med Chem. 2015 Aug 13;58(15):5789-807. doi: 10.1021/acs.jmedchem.5b00310. Epub 2015 Jul 20.

10.

Effect of acyclic monoterpene alcohols and their derivatives on TRP channels.

Ortar G, Schiano Moriello A, Morera E, Nalli M, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2014 Dec 1;24(23):5507-11. doi: 10.1016/j.bmcl.2014.10.012. Epub 2014 Oct 12.

PMID:
25455494
11.

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Sisinni L, Bolognesi A, Rensen WM, Miele A, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Brancale A, Novellino E, Dondio G, Vultaggio S, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R.

J Med Chem. 2014 Aug 14;57(15):6531-52. doi: 10.1021/jm500561a. Epub 2014 Jul 29.

12.

3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.

Ortar G, Schiano Moriello A, Morera E, Nalli M, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5614-8. doi: 10.1016/j.bmcl.2013.08.039. Epub 2013 Aug 14.

PMID:
23993334
13.

Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.

Ortar G, Morera E, De Petrocellis L, Ligresti A, Schiano Moriello A, Morera L, Nalli M, Ragno R, Pirolli A, Di Marzo V.

Eur J Med Chem. 2013 May;63:118-32. doi: 10.1016/j.ejmech.2013.02.005. Epub 2013 Feb 15.

PMID:
23474898
14.

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.

La Regina G, Bai R, Rensen WM, Di Cesare E, Coluccia A, Piscitelli F, Famiglini V, Reggio A, Nalli M, Pelliccia S, Da Pozzo E, Costa B, Granata I, Porta A, Maresca B, Soriani A, Iannitto ML, Santoni A, Li J, Miranda Cona M, Chen F, Ni Y, Brancale A, Dondio G, Vultaggio S, Varasi M, Mercurio C, Martini C, Hamel E, Lavia P, Novellino E, Silvestri R.

J Med Chem. 2013 Jan 10;56(1):123-49. doi: 10.1021/jm3013097. Epub 2012 Dec 27.

15.

Tetrahydro-β-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels.

Ortar G, De Petrocellis L, Moriello AS, Allarà M, Morera E, Nalli M, Di Marzo V.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):138-42. doi: 10.1016/j.bmcl.2012.10.137. Epub 2012 Nov 12.

PMID:
23206861
16.

Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds.

Ortar G, Morera L, Moriello AS, Morera E, Nalli M, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2012 May 15;22(10):3535-9. doi: 10.1016/j.bmcl.2012.03.055. Epub 2012 Mar 20.

PMID:
22503249
17.

Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators.

Morera E, De Petrocellis L, Morera L, Moriello AS, Nalli M, Di Marzo V, Ortar G.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1674-7. doi: 10.1016/j.bmcl.2011.12.113. Epub 2011 Dec 31.

PMID:
22257892
18.

(-)-Menthylamine derivatives as potent and selective antagonists of transient receptor potential melastatin type-8 (TRPM8) channels.

Ortar G, De Petrocellis L, Morera L, Moriello AS, Orlando P, Morera E, Nalli M, Di Marzo V.

Bioorg Med Chem Lett. 2010 May 1;20(9):2729-32. doi: 10.1016/j.bmcl.2010.03.076. Epub 2010 Mar 25.

PMID:
20378345
19.

Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands.

Morera E, De Petrocellis L, Morera L, Moriello AS, Ligresti A, Nalli M, Woodward DF, Di Marzo V, Ortar G.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6806-9. doi: 10.1016/j.bmcl.2009.09.033. Epub 2009 Oct 20.

PMID:
19875281
20.

Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo.

Bisogno T, Ortar G, Petrosino S, Morera E, Palazzo E, Nalli M, Maione S, Di Marzo V; Endocannabinoid Research Group.

Biochim Biophys Acta. 2009 Jan;1791(1):53-60. doi: 10.1016/j.bbalip.2008.10.007. Epub 2008 Nov 5.

PMID:
19027877

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