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Items: 1 to 20 of 33

1.

Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines.

Ammazzalorso A, De Lellis L, Florio R, Laghezza A, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Tortorella P, Veschi S, Loiodice F, Cama A, Amoroso R.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2302-2306. doi: 10.1016/j.bmcl.2019.06.020. Epub 2019 Jun 18.

PMID:
31272790
2.

PPAR Ligands Containing Stilbene Scaffold.

Fantacuzzi M, De Filippis B, Amoroso R, Giampietro L.

Mini Rev Med Chem. 2019 Jun 2. doi: 10.2174/1389557519666190603085026. [Epub ahead of print]

PMID:
31161987
3.

Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies.

Ammazzalorso A, Carradori S, Angeli A, Akdemir A, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Amoroso R, Supuran CT.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1051-1061. doi: 10.1080/14756366.2019.1611801.

4.

Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome.

Giampietro L, Laghezza A, Cerchia C, Florio R, Recinella L, Capone F, Ammazzalorso A, Bruno I, De Filippis B, Fantacuzzi M, Ferrante C, Maccallini C, Tortorella P, Verginelli F, Brunetti L, Cama A, Amoroso R, Loiodice F, Lavecchia A.

ACS Med Chem Lett. 2019 Feb 25;10(4):545-551. doi: 10.1021/acsmedchemlett.8b00574. eCollection 2019 Apr 11.

PMID:
30996794
5.

The Selective Acetamidine-Based iNOS Inhibitor CM544 Reduces Glioma Cell Proliferation by Enhancing PARP-1 Cleavage In Vitro.

Gallorini M, Maccallini C, Ammazzalorso A, Amoia P, De Filippis B, Fantacuzzi M, Giampietro L, Cataldi A, Amoroso R.

Int J Mol Sci. 2019 Jan 24;20(3). pii: E495. doi: 10.3390/ijms20030495.

6.

Discovery of new FXR agonists based on 6-ECDCA binding properties by virtual screening and molecular docking.

Giancristofaro A, Barbosa AJM, Ammazzalorso A, Amoia P, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Amoroso R.

Medchemcomm. 2018 Jul 4;9(10):1630-1638. doi: 10.1039/c8md00272j. eCollection 2018 Oct 1.

7.

Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma.

Maccallini C, Di Matteo M, Gallorini M, Montagnani M, Graziani V, Ammazzalorso A, Amoia P, De Filippis B, Di Silvestre S, Fantacuzzi M, Giampietro L, Potenza MA, Re N, Pandolfi A, Cataldi A, Amoroso R.

Eur J Med Chem. 2018 May 25;152:53-64. doi: 10.1016/j.ejmech.2018.04.027. Epub 2018 Apr 13.

PMID:
29689474
8.

Cytotoxic effect of a family of peroxisome proliferator-activated receptor antagonists in colorectal and pancreatic cancer cell lines.

Ammazzalorso A, De Lellis L, Florio R, Bruno I, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Perconti S, Verginelli F, Cama A, Amoroso R.

Chem Biol Drug Des. 2017 Nov;90(5):1029-1035. doi: 10.1111/cbdd.13026. Epub 2017 Jul 19.

PMID:
28544586
9.

Anticancer Activity of Stilbene-Based Derivatives.

De Filippis B, Ammazzalorso A, Fantacuzzi M, Giampietro L, Maccallini C, Amoroso R.

ChemMedChem. 2017 Apr 20;12(8):558-570. doi: 10.1002/cmdc.201700045. Epub 2017 Mar 28. Review.

PMID:
28266812
10.

Indazole, Pyrazole, and Oxazole Derivatives Targeting Nitric Oxide Synthases and Carbonic Anhydrases.

Maccallini C, Di Matteo M, Vullo D, Ammazzalorso A, Carradori S, De Filippis B, Fantacuzzi M, Giampietro L, Pandolfi A, Supuran CT, Amoroso R.

ChemMedChem. 2016 Aug 19;11(16):1695-9. doi: 10.1002/cmdc.201600204. Epub 2016 Jul 5.

PMID:
27377568
11.

Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors.

Di Matteo M, Ammazzalorso A, Andreoli F, Caffa I, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Nencioni A, Parenti MD, Soncini D, Del Rio A, Amoroso R.

Bioorg Med Chem Lett. 2016 Jul 1;26(13):3192-3194. doi: 10.1016/j.bmcl.2016.04.078. Epub 2016 Apr 28.

PMID:
27161804
12.

Synthesis, in vitro evaluation, and molecular modeling investigation of benzenesulfonimide peroxisome proliferator-activated receptors α antagonists.

Ammazzalorso A, Carrieri A, Verginelli F, Bruno I, Carbonara G, D'Angelo A, De Filippis B, Fantacuzzi M, Florio R, Fracchiolla G, Giampietro L, Giancristofaro A, Maccallini C, Cama A, Amoroso R.

Eur J Med Chem. 2016 May 23;114:191-200. doi: 10.1016/j.ejmech.2016.02.064. Epub 2016 Feb 27.

PMID:
26974385
13.

Screening of NOS activity and selectivity of newly synthesized acetamidines using RP-HPLC.

Fantacuzzi M, Maccallini C, Di Matteo M, Ammazzalorso A, Bruno I, De Filippis B, Giampietro L, Mollica A, Amoroso R.

J Pharm Biomed Anal. 2016 Feb 20;120:419-24. doi: 10.1016/j.jpba.2015.11.045. Epub 2015 Dec 2.

PMID:
26689740
14.

Synthesis of Naphthyl-, Quinolin- and Anthracenyl Analogues of Clofibric Acid as PPARα Agonists.

Giampietro L, Ammazzalorso A, Bruno I, Carradori S, De Filippis B, Fantacuzzi M, Giancristofaro A, Maccallini C, Amoroso R.

Chem Biol Drug Des. 2016 Mar;87(3):467-71. doi: 10.1111/cbdd.12677. Epub 2015 Nov 20.

PMID:
26502898
15.

Selective Acetamidine-Based Nitric Oxide Synthase Inhibitors: Synthesis, Docking, and Biological Studies.

Maccallini C, Montagnani M, Paciotti R, Ammazzalorso A, De Filippis B, Di Matteo M, Di Silvestre S, Fantacuzzi M, Giampietro L, Potenza MA, Re N, Pandolfi A, Amoroso R.

ACS Med Chem Lett. 2015 Apr 28;6(6):635-40. doi: 10.1021/acsmedchemlett.5b00149. eCollection 2015 Jun 11.

16.

Structural development studies of PPARs ligands based on tyrosine scaffold.

De Filippis B, Linciano P, Ammazzalorso A, Di Giovanni C, Fantacuzzi M, Giampietro L, Laghezza A, Maccallini C, Tortorella P, Lavecchia A, Loiodice F, Amoroso R.

Eur J Med Chem. 2015 Jan 7;89:817-25. doi: 10.1016/j.ejmech.2014.10.083. Epub 2014 Oct 31.

PMID:
25462281
17.

Reversed-phase high-performance liquid chromatography method with fluorescence detection to screen nitric oxide synthases inhibitors.

Maccallini C, Di Matteo M, Ammazzalorso A, D'Angelo A, De Filippis B, Di Silvestre S, Fantacuzzi M, Giampietro L, Pandolfi A, Amoroso R.

J Sep Sci. 2014 Jun;37(12):1380-5. doi: 10.1002/jssc.201400059. Epub 2014 Apr 29.

PMID:
24687974
18.

Amidine-based bioactive compounds for the regulation of arginine metabolism.

Maccallini C, Fantacuzzi M, Amoroso R.

Mini Rev Med Chem. 2013 Jul;13(9):1305-10. Review.

PMID:
23621655
19.

Effect of stilbene and chalcone scaffolds incorporation in clofibric acid on PPARα agonistic activity.

Giampietro L, D'Angelo A, Giancristofaro A, Ammazzalorso A, De Filippis B, Di Matteo M, Fantacuzzi M, Linciano P, Maccallini C, Amoroso R.

Med Chem. 2014;10(1):59-65.

PMID:
23432317
20.

Fibrate-derived N-(methylsulfonyl)amides with antagonistic properties on PPARα.

Ammazzalorso A, D'Angelo A, Giancristofaro A, De Filippis B, Di Matteo M, Fantacuzzi M, Giampietro L, Linciano P, Maccallini C, Amoroso R.

Eur J Med Chem. 2012 Dec;58:317-22. doi: 10.1016/j.ejmech.2012.10.019. Epub 2012 Oct 23.

PMID:
23137448

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