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Items: 1 to 20 of 43

1.

5-Nitro-Thiophene-Thiosemicarbazone Derivatives Present Antitumor Activity Mediated by Apoptosis and DNA Intercalation.

Roque Marques KM, do Desterro MR, de Arruda SM, de-Araújo Neto LN, de Lima MDCA, de Almeida SMV, Silva ECDD, Aquino TM, Júnior EFDS, Júnior JXD, Silva MM, de A Dantas MD, C Santos JC, Figueiredo IM, Bazin MA, Marchand P, da Silva TG, Mendonça Junior FJB.

Curr Top Med Chem. 2019 Jun 21. doi: 10.2174/1568026619666190621120304. [Epub ahead of print]

PMID:
31223089
2.

Synthesis, DNA and protein interactions and human topoisomerase inhibition of novel Spiroacridine derivatives.

Gouveia RG, Ribeiro AG, Segundo MÂSP, de Oliveira JF, de Lima MDCA, de Lima Souza TRC, de Almeida SMV, de Moura RO.

Bioorg Med Chem. 2018 Dec 1;26(22):5911-5921. doi: 10.1016/j.bmc.2018.10.038. Epub 2018 Oct 29.

PMID:
30420325
3.

Spiro-acridine inhibiting tyrosinase enzyme: Kinetic, protein-ligand interaction and molecular docking studies.

Menezes TM, de Almeida SMV, de Moura RO, Seabra G, de Lima MDCA, Neves JL.

Int J Biol Macromol. 2019 Feb 1;122:289-297. doi: 10.1016/j.ijbiomac.2018.10.175. Epub 2018 Oct 26.

PMID:
30401647
4.

Synthesis, in vitro and in vivo biological evaluation, COX-1/2 inhibition and molecular docking study of indole-N-acylhydrazone derivatives.

Moraes ADTO, Miranda MDS, Jacob ÍTT, Amorim CADC, Moura RO, Silva SÂSD, Soares MBP, Almeida SMV, Souza TRCL, Oliveira JF, Silva TGD, Melo CML, Moreira DRM, Lima MDCA.

Bioorg Med Chem. 2018 Nov 1;26(20):5388-5396. doi: 10.1016/j.bmc.2018.07.024. Epub 2018 Jul 17.

PMID:
30293795
5.

Thermodynamic Characterization of Mixed Monolayers of a Novel Oxazolidine Derivative and Phospholipids.

Rocha FS, da Silva RR, Codeceira GHR, de Lima MDCA, Pitta IDR, de Oliveira MDL, de Andrade CAS.

J Membr Biol. 2018 Dec;251(5-6):723-733. doi: 10.1007/s00232-018-0049-4. Epub 2018 Oct 3.

PMID:
30283978
6.

New thiophene-acridine compounds: Synthesis, antileishmanial activity, DNA binding, chemometric, and molecular docking studies.

de Lima Serafim V, Félix MB, Frade Silva DK, Rodrigues KADF, Andrade PN, de Almeida SMV, de Albuquerque Dos Santos S, de Oliveira JF, de Lima MDCA, Mendonça-Junior FJB, Scotti MT, de Oliveira MR, de Moura RO.

Chem Biol Drug Des. 2018 Jun;91(6):1141-1155. doi: 10.1111/cbdd.13176. Epub 2018 Mar 25.

PMID:
29415325
7.

New 1,3-benzodioxole derivatives: Synthesis, evaluation of in vitro schistosomicidal activity and ultrastructural analysis.

Mariz Gomes da Silva LM, de Oliveira JF, Silva WL, da Silva AL, de Almeida Junior ASA, Barbosa Dos Santos VH, Alves LC, Brayner Dos Santos FA, Costa VMA, Aires AL, de Lima MDCA, Albuquerque MCPA.

Chem Biol Interact. 2018 Mar 1;283:20-29. doi: 10.1016/j.cbi.2018.01.016. Epub 2018 Jan 31.

8.

Anticancer properties of thiophene derivatives in breast cancer MCF-7 cells.

Dos Santos FA, Pereira MC, de Oliveira TB, Mendonça Junior FJB, de Lima MDCA, Pitta MGDR, Pitta IDR, de Melo Rêgo MJB, da Rocha Pitta MG.

Anticancer Drugs. 2017 Dec 18. doi: 10.1097/CAD.0000000000000581. [Epub ahead of print]

PMID:
29256900
9.

DNA binding and Topoisomerase inhibition: How can these mechanisms be explored to design more specific anticancer agents?

de Almeida SMV, Ribeiro AG, de Lima Silva GC, Ferreira Alves JE, Beltrão EIC, de Oliveira JF, de Carvalho LB Junior, Alves de Lima MDC.

Biomed Pharmacother. 2017 Dec;96:1538-1556. doi: 10.1016/j.biopha.2017.11.054. Epub 2017 Nov 22. Review.

PMID:
29174576
10.

Synthesis of novel indole derivatives as promising DNA-binding agents and evaluation of antitumor and antitopoisomerase I activities.

Lafayette EA, de Almeida SMV, Cavalcanti Santos RV, de Oliveira JF, Amorim CADC, da Silva RMF, Pitta MGDR, Pitta IDR, de Moura RO, de Carvalho Júnior LB, de Melo Rêgo MJB, de Lima MDCA.

Eur J Med Chem. 2017 Aug 18;136:511-522. doi: 10.1016/j.ejmech.2017.05.012. Epub 2017 May 4.

PMID:
28531811
11.

Synthesis and in vitro anticancer activity of new 2-thioxo-oxazolidin-4-one derivatives.

Campos JF, Pereira MC, de Sena WLB, de Barros Martins CG, de Oliveira JF, da Cruz Amorim CA, de Melo Rêgo MJB, da Rocha Pitta MG, de Lima MDCA, da Rocha Pitta MG, da Rocha Pitta I.

Pharmacol Rep. 2017 Aug;69(4):633-641. doi: 10.1016/j.pharep.2017.03.005. Epub 2017 Mar 18.

PMID:
28511054
12.

Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase inhibition assay.

de Oliveira JF, Lima TS, Vendramini-Costa DB, de Lacerda Pedrosa SCB, Lafayette EA, da Silva RMF, de Almeida SMV, de Moura RO, Ruiz ALTG, de Carvalho JE, de Lima MDCA.

Eur J Med Chem. 2017 Aug 18;136:305-314. doi: 10.1016/j.ejmech.2017.05.023. Epub 2017 May 8.

PMID:
28505535
13.

Medicinal chemistry of antischistosomal drugs: Praziquantel and oxamniquine.

da Silva VBR, Campos BRKL, de Oliveira JF, Decout JL, do Carmo Alves de Lima M.

Bioorg Med Chem. 2017 Jul 1;25(13):3259-3277. doi: 10.1016/j.bmc.2017.04.031. Epub 2017 Apr 27. Review.

PMID:
28495384
14.

Synthesis, cytotoxicity and antifungal activity of 5-nitro-thiophene-thiosemicarbazones derivatives.

de Araújo Neto LN, do Carmo Alves de Lima M, de Oliveira JF, de Souza ER, Buonafina MDS, Vitor Anjos MN, Brayner FA, Alves LC, Neves RP, Mendonça-Junior FJB.

Chem Biol Interact. 2017 Jun 25;272:172-181. doi: 10.1016/j.cbi.2017.05.005. Epub 2017 May 4.

15.

Synthesis and biological evaluation of novel imidazolidine derivatives as candidates to schistosomicidal agents.

Matos-Rocha TJ, Lima MD, Silva AL, Oliveira JF, Gouveia AL, Silva VB, Almeida AS Júnior, Brayner FA, Cardoso PR, Pitta-Galdino MD, Pitta ID, Rêgo MJ, Alves LC, Pitta MG.

Rev Inst Med Trop Sao Paulo. 2017 Apr 3;59:e8. doi: 10.1590/S1678-9946201759008.

16.

Chronic LPSF/GQ-02 treatment attenuates inflammation and atherosclerosis development in LDLr-/- mice.

Silva AKSE, Gomes FODS, Santos Silva BD, Ribeiro EL, Oliveira AC, Araújo SMDR, de Lima IT, Oliveira AGV, Rudnicki M, Abdalla DSP, Lima MDCA, Pitta IDR, Peixoto CA.

Eur J Pharmacol. 2016 Nov 15;791:622-631. doi: 10.1016/j.ejphar.2016.09.037. Epub 2016 Sep 29.

PMID:
27693798
17.

In vivo study of schistosomicidal action of 1-benzyl-4-[(4-fluoro-phenyl)-hydrazono]-5-thioxo-imidazolidin-2-one.

da Silva AL, de Oliveira JF, Silva WL, Luis AF, de Farias Santiago E, Alves de Almeida Júnior AS, de Oliveira TB, de Souza VCA, de Barros AF, Pitta IDR, de Oliveira SA, Alves de Lima MDC.

Biomed Pharmacother. 2016 Oct;83:502-507. doi: 10.1016/j.biopha.2016.07.008. Epub 2016 Jul 18.

PMID:
27434866
18.

Ultrastructural Assessment of 2-(acridin-9-ylmethylene)-N-phenylhydrazinecarbothioamide activity on human breast adenocarcinoma cells.

de Almeida SMV, da Silva LPBG, de Lima LRA, Longato GB, Padilha RJR, Alves LC, Brayner FA, Ruiz ALTG, de Carvalho JE, Beltrão EIC, de Lima MDCA, de Carvalho Júnior LB.

Micron. 2016 Nov;90:114-122. doi: 10.1016/j.micron.2016.08.009. Epub 2016 Aug 30.

PMID:
27668344
19.

UHPLC Quantitation Method for New Thiazolidinedione LPSF/GQ-02 and In Vitro/In Vivo Kinetic Studies.

Vieira CM, Campos ML, Padilha EC, Pitta M, Pitta ID, de Lima MD, Peccinini RG.

Drug Metab Lett. 2016;10(3):206-212.

PMID:
27456668
20.

New spiro-acridines: DNA interaction, antiproliferative activity and inhibition of human DNA topoisomerases.

Almeida SM, Lafayette EA, Silva WL, Lima Serafim V, Menezes TM, Neves JL, Ruiz AL, Carvalho JE, Moura RO, Beltrão EI, Carvalho Júnior LB, Lima MD.

Int J Biol Macromol. 2016 Nov;92:467-475. doi: 10.1016/j.ijbiomac.2016.07.057. Epub 2016 Jul 18.

PMID:
27435006

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