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Items: 20


Mitochondrial Flexibility of Breast Cancers: A Growth Advantage and a Therapeutic Opportunity.

Avagliano A, Ruocco MR, Aliotta F, Belviso I, Accurso A, Masone S, Montagnani S, Arcucci A.

Cells. 2019 Apr 30;8(5). pii: E401. doi: 10.3390/cells8050401. Review.


Metabolic Reprogramming of Cancer Associated Fibroblasts: The Slavery of Stromal Fibroblasts.

Avagliano A, Granato G, Ruocco MR, Romano V, Belviso I, Carfora A, Montagnani S, Arcucci A.

Biomed Res Int. 2018 Jun 5;2018:6075403. doi: 10.1155/2018/6075403. eCollection 2018. Review.


Involvement of Breast Cancer-Associated Fibroblasts in Tumor Development, Therapy Resistance and Evaluation of Potential Therapeutic Strategies.

Ruocco MR, Avagliano A, Granato G, Imparato V, Masone S, Masullo M, Nasso R, Montagnani S, Arcucci A.

Curr Med Chem. 2018;25(29):3414-3434. doi: 10.2174/0929867325666180309120746. Review.


Cancer: An Oxidative Crosstalk between Solid Tumor Cells and Cancer Associated Fibroblasts.

Arcucci A, Ruocco MR, Granato G, Sacco AM, Montagnani S.

Biomed Res Int. 2016;2016:4502846. doi: 10.1155/2016/4502846. Epub 2016 Aug 9. Review.


Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells.

Capasso A, Cerchia C, Di Giovanni C, Granato G, Albano F, Romano S, De Vendittis E, Ruocco MR, Lavecchia A.

Oncotarget. 2015 Nov 24;6(37):40202-22. doi: 10.18632/oncotarget.5473.


Evaluation of cytotoxic effects of 7-dehydrocholesterol on melanoma cells.

Gelzo M, Granato G, Albano F, Arcucci A, Dello Russo A, De Vendittis E, Ruocco MR, Corso G.

Free Radic Biol Med. 2014 May;70:129-40. doi: 10.1016/j.freeradbiomed.2014.02.013. Epub 2014 Feb 20.


Structural and denaturation studies of two mutants of a cold adapted superoxide dismutase point to the importance of electrostatic interactions in protein stability.

Merlino A, Russo Krauss I, Castellano I, Ruocco MR, Capasso A, De Vendittis E, Rossi B, Sica F.

Biochim Biophys Acta. 2014 Mar;1844(3):632-40. doi: 10.1016/j.bbapap.2014.01.007. Epub 2014 Jan 17.


Markers of mitochondrial dysfunction during the diclofenac-induced apoptosis in melanoma cell lines.

Albano F, Arcucci A, Granato G, Romano S, Montagnani S, De Vendittis E, Ruocco MR.

Biochimie. 2013 Apr;95(4):934-45. doi: 10.1016/j.biochi.2012.12.012. Epub 2012 Dec 26.


Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability.

Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L.

J Struct Biol. 2012 Feb;177(2):506-12. doi: 10.1016/j.jsb.2011.10.014. Epub 2011 Nov 7.


Diclofenac-induced apoptosis in the neuroblastoma cell line SH-SY5Y: possible involvement of the mitochondrial superoxide dismutase.

Cecere F, Iuliano A, Albano F, Zappelli C, Castellano I, Grimaldi P, Masullo M, De Vendittis E, Ruocco MR.

J Biomed Biotechnol. 2010;2010:801726. doi: 10.1155/2010/801726. Epub 2010 Jun 17.


Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells.

Cassano S, Agnese S, D'Amato V, Papale M, Garbi C, Castagnola P, Ruocco MR, Castellano I, De Vendittis E, Santillo M, Amente S, Porcellini A, Avvedimento EV.

J Biol Chem. 2010 Jul 30;285(31):24141-53. doi: 10.1074/jbc.M109.098525. Epub 2010 May 21.


The dimeric structure of Sulfolobus solfataricus thioredoxin A2 and the basis of its thermostability.

Ruggiero A, Masullo M, Marasco D, Ruocco MR, Grimaldi P, Arcari P, Zagari A, Vitagliano L.

Proteins. 2009 Dec;77(4):1004-8. doi: 10.1002/prot.22559. No abstract available.


Crystallization and preliminary X-ray crystallographic analysis of two dimeric hyperthermostable thioredoxins isolated from Sulfolobus solfataricus.

Ruggiero A, Lanzotti MA, Ruocco MR, Grimaldi P, Marasco D, Arcari P, Masullo M, Zagari A, Vitagliano L.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jun 1;65(Pt 6):604-7. doi: 10.1107/S1744309109016200. Epub 2009 May 22.


Rat mitochondrial manganese superoxide dismutase: amino acid positions involved in covalent modifications, activity, and heat stability.

Castellano I, Cecere F, De Vendittis A, Cotugno R, Chambery A, Di Maro A, Michniewicz A, Parlato G, Masullo M, Avvedimento EV, De Vendittis E, Ruocco MR.

Biopolymers. 2009 Dec;91(12):1215-26. doi: 10.1002/bip.21208.


Differential cold-adaptation among protein components of the thioredoxin system in the psychrophilic eubacterium Pseudoalteromonas haloplanktis TAC 125.

Cotugno R, Rosaria Ruocco M, Marco S, Falasca P, Evangelista G, Raimo G, Chambery A, Di Maro A, Masullo M, De Vendittis E.

Mol Biosyst. 2009 May;5(5):519-28. doi: 10.1039/b818467d. Epub 2009 Mar 23.


Structure and stability of a thioredoxin reductase from Sulfolobus solfataricus: a thermostable protein with two functions.

Ruggiero A, Masullo M, Ruocco MR, Grimaldi P, Lanzotti MA, Arcari P, Zagari A, Vitagliano L.

Biochim Biophys Acta. 2009 Mar;1794(3):554-62. doi: 10.1016/j.bbapap.2008.11.011. Epub 2008 Dec 6.


Characterisation of the components of the thioredoxin system in the archaeon Sulfolobus solfataricus.

Grimaldi P, Ruocco MR, Lanzotti MA, Ruggiero A, Ruggiero I, Arcari P, Vitagliano L, Masullo M.

Extremophiles. 2008 Jul;12(4):553-62. doi: 10.1007/s00792-008-0161-y. Epub 2008 Apr 17.


Glutathionylation of the iron superoxide dismutase from the psychrophilic eubacterium Pseudoalteromonas haloplanktis.

Castellano I, Ruocco MR, Cecere F, Di Maro A, Chambery A, Michniewicz A, Parlato G, Masullo M, De Vendittis E.

Biochim Biophys Acta. 2008 May;1784(5):816-26. doi: 10.1016/j.bbapap.2008.02.003. Epub 2008 Feb 16.


Adaptation of model proteins from cold to hot environments involves continuous and small adjustments of average parameters related to amino acid composition.

De Vendittis E, Castellano I, Cotugno R, Ruocco MR, Raimo G, Masullo M.

J Theor Biol. 2008 Jan 7;250(1):156-71. Epub 2007 Sep 14.


Crystallization and preliminary X-ray crystallographic analysis of Sulfolobus solfataricus thioredoxin reductase.

Ruggiero A, Ruocco MR, Grimaldi P, Arcari P, Masullo M, Zagari A, Vitagliano L.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 1;61(Pt 10):906-9. Epub 2005 Sep 30.

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