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Items: 1 to 20 of 61

1.

A New Topical Eye Drop Containing LyeTxI-b, A Synthetic Peptide Designed from A Lycosa erithrognata Venom Toxin, Was Effective to Treat Resistant Bacterial Keratitis.

Silva CND, Silva FRD, Dourado LFN, Reis PVMD, Silva RO, Costa BLD, Nunes PS, Amaral FA, Santos VLD, de Lima ME, Silva Cunha Júnior AD.

Toxins (Basel). 2019 Apr 4;11(4). pii: E203. doi: 10.3390/toxins11040203.

2.

PnPP-19 Peptide Restores Erectile Function in Hypertensive and Diabetic Animals Through Intravenous and Topical Administration.

Nunes da Silva C, Nunes KP, De Marco Almeida F, Silva Costa FL, Borges PV, Lacativa P, Pimenta AMC, Elena de Lima M.

J Sex Med. 2019 Mar;16(3):365-374. doi: 10.1016/j.jsxm.2019.01.004. Epub 2019 Feb 14.

PMID:
30773502
3.

Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors.

Peigneur S, Cheneval O, Maiti M, Leipold E, Heinemann SH, Lescrinier E, Herdewijn P, De Lima ME, Craik DJ, Schroeder CI, Tytgat J.

FASEB J. 2019 Mar;33(3):3693-3703. doi: 10.1096/fj.201801909R. Epub 2018 Dec 3.

PMID:
30509130
4.

Intravitreal injection of the synthetic peptide LyeTx I b, derived from a spider toxin, into the rabbit eye is safe and prevents neovascularization in a chorio-allantoic membrane model.

Silva FRD, Paiva MRB, Dourado LFN, Silva RO, Silva CND, Costa BLD, Toledo CR, de Lima ME, Silva-Cunha AD.

J Venom Anim Toxins Incl Trop Dis. 2018 Nov 21;24:31. doi: 10.1186/s40409-018-0168-5. eCollection 2018.

5.

The synthetic peptide LyeTxI-b derived from Lycosa erythrognatha spider venom is cytotoxic to U-87 MG glioblastoma cells.

Abdel-Salam MAL, Carvalho-Tavares J, Gomes KS, Teixeira-Carvalho A, Kitten GT, Nyffeler J, Dias FF, Dos Reis PVM, Pimenta AMC, Leist M, de Lima ME, de Souza-Fagundes EM.

Amino Acids. 2019 Mar;51(3):433-449. doi: 10.1007/s00726-018-2678-4. Epub 2018 Nov 17.

PMID:
30449002
6.

Sequence analysis of the cDNA encoding for SpCTx: a lethal factor from scorpionfish venom (Scorpaena plumieri).

Costa FLS, De Lima ME, Figueiredo SG, Ferreira RS, Prates NS, Sakamoto T, Salas CE.

J Venom Anim Toxins Incl Trop Dis. 2018 Aug 29;24:24. doi: 10.1186/s40409-018-0158-7. eCollection 2018.

7.

Phoneutria nigriventer Spider Toxin PnTx2-1 (δ-Ctenitoxin-Pn1a) Is a Modulator of Sodium Channel Gating.

Peigneur S, Paiva ALB, Cordeiro MN, Borges MH, Diniz MRV, de Lima ME, Tytgat J.

Toxins (Basel). 2018 Aug 21;10(9). pii: E337. doi: 10.3390/toxins10090337.

8.

Ts1 from the Brazilian scorpion Tityus serrulatus: A half-century of studies on a multifunctional beta like-toxin.

Martin-Eauclaire MF, Bougis PE, de Lima ME.

Toxicon. 2018 Sep 15;152:106-120. doi: 10.1016/j.toxicon.2018.07.024. Epub 2018 Jul 29. Review.

PMID:
30059695
9.

Phoneutria nigriventer venom: A pharmacological treasure.

Peigneur S, de Lima ME, Tytgat J.

Toxicon. 2018 Sep 1;151:96-110. doi: 10.1016/j.toxicon.2018.07.008. Epub 2018 Jul 10. Review.

PMID:
30003916
10.

Hydrophobic Nanoprecipitates of β-Cyclodextrin/Avermectins Inclusion Compounds Reveal Insecticide Activity against Aedes aegypti Larvae and Low Toxicity against Fibroblasts.

Dos Santos Moreira AM, Bittencourt VCE, Costa FLS, Elena de Lima M, Lopes MTP, Borges WS, Martins GF, Nascimento CS Jr, da Silva JG, Denadai ÂML, Borges KB.

J Agric Food Chem. 2018 Jul 18;66(28):7275-7285. doi: 10.1021/acs.jafc.8b01300. Epub 2018 Jul 9.

PMID:
29925239
11.

PnTx2-6 (or δ-CNTX-Pn2a), a toxin from Phoneutria nigriventer spider venom, releases l-glutamate from rat brain synaptosomes involving Na+ and Ca2+ channels and changes protein expression at the blood-brain barrier.

Silva CND, Lomeo RS, Torres FS, Borges MH, Nascimento MC, Rodrigues Mesquita-Britto MH, Rapôso C, Pimenta AMC, da Cruz-Höfling MA, Gomes DA, de Lima ME.

Toxicon. 2018 Aug;150:280-288. doi: 10.1016/j.toxicon.2018.06.073. Epub 2018 Jun 15.

PMID:
29913196
12.

NMR structures in different membrane environments of three ocellatin peptides isolated from Leptodactylus labyrinthicus.

Gomes KAGG, Dos Santos DM, Santos VM, Piló-Veloso D, Mundim HM, Rodrigues LV, Lião LM, Verly RM, de Lima ME, Resende JM.

Peptides. 2018 May;103:72-83. doi: 10.1016/j.peptides.2018.03.016. Epub 2018 Mar 26.

PMID:
29596881
13.

Physicochemical Characterization and Skin Permeation of Cationic Transfersomes Containing the Synthetic Peptide PnPP-19.

De Marco Almeida F, Silva CN, de Araujo Lopes SC, Santos DM, Torres FS, Cardoso FL, Martinelli PM, da Silva ER, de Lima ME, Miranda LAF, Oliveira MC.

Curr Drug Deliv. 2018;15(7):1064-1071. doi: 10.2174/1567201815666180108170206.

PMID:
29318970
14.

Comparative analyses and implications for antivenom serotherapy of four Moroccan scorpion Buthus occitanus venoms: Subspecies tunetanus, paris, malhommei, and mardochei.

Emerich BL, De Lima ME, Martin-Eauclaire MF, Bougis PE.

Toxicon. 2018 Jul;149:26-36. doi: 10.1016/j.toxicon.2017.07.010. Epub 2017 Jul 13.

15.

Upregulation of p38 pathway accelerates proliferation and migration of MDA-MB-231 breast cancer cells.

Huth HW, Santos DM, Gravina HD, Resende JM, Goes AM, de Lima ME, Ropert C.

Oncol Rep. 2017 Apr;37(4):2497-2505. doi: 10.3892/or.2017.5452. Epub 2017 Feb 14.

PMID:
28260101
16.

Ocellatin peptides from the skin secretion of the South American frog Leptodactylus labyrinthicus (Leptodactylidae): characterization, antimicrobial activities and membrane interactions.

Gusmão KAG, Dos Santos DM, Santos VM, Cortés ME, Reis PVM, Santos VL, Piló-Veloso D, Verly RM, de Lima ME, Resende JM.

J Venom Anim Toxins Incl Trop Dis. 2017 Jan 19;23:4. doi: 10.1186/s40409-017-0094-y. eCollection 2017.

17.

Moving pieces in a cryptomic puzzle: Cryptide from Tityus serrulatus Ts3 Nav toxin as potential agonist of muscarinic receptors.

Rocha-Resende C, Leão NM, de Lima ME, Santos RA, Pimenta AMC, Verano-Braga T.

Peptides. 2017 Dec;98:70-77. doi: 10.1016/j.peptides.2016.12.018. Epub 2016 Dec 29.

PMID:
28041976
18.

A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems.

da Fonseca Pacheco D, Freitas AC, Pimenta AM, Duarte ID, de Lima ME.

J Venom Anim Toxins Incl Trop Dis. 2016 Dec 21;22:34. doi: 10.1186/s40409-016-0091-6. eCollection 2016.

19.

Antibacterial Effect of Synthetic Peptide LyeTxI and LyeTxI/β-Cyclodextrin Association Compound Against Planktonic and Multispecies Biofilms of Periodontal Pathogens.

Cruz Olivo EA, Santos D, de Lima ME, Dos Santos VL, Sinisterra RD, Cortés ME.

J Periodontol. 2017 Jun;88(6):e88-e96. doi: 10.1902/jop.2016.160438. Epub 2016 Dec 17.

PMID:
27989223
20.

Ts14 from Tityus serrulatus boosts angiogenesis and attenuates inflammation and collagen deposition in sponge-induced granulation tissue in mice.

Cassini-Vieira P, Felipetto M, Prado LB, Verano-Braga T, Andrade SP, Santos RAS, Teixeira MM, de Lima ME, Pimenta AMC, Barcelos LS.

Peptides. 2017 Dec;98:63-69. doi: 10.1016/j.peptides.2016.10.002. Epub 2016 Oct 11.

PMID:
27732900

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