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Nutrients. 2018 May 7;10(5). pii: E573. doi: 10.3390/nu10050573.

Efficacy of a Gluten-Free Diet in the Gilles de la Tourette Syndrome: A Pilot Study.

Author information

1
Gastroenterology Unit, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s/n, 33011 Oviedo, Spain. lrodrigosaez@gmail.com.
2
Gastroenterology Unit, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s/n, 33011 Oviedo, Spain. nuriaalvarezh@gmail.com.
3
Technical Department, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s/n, 33011 Oviedo, Spain. bustillo.e@telefonica.net.
4
Neurology Service, Hospital del Valle de Hebrón, Paseo del Valle de Hebrón 119, 08035 Barcelona, Spain. jsalasp@meditex.es.
5
Psychiatry Service, Mental Health Center, Pedro Pablo 42, 33209 Gijón, Spain. marcoshuerta47@gmail.com.
6
Neurology Service, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s/n, 33011 Oviedo, Spain. carloshlahoz@gmail.com.

Abstract

The Gilles de la Tourette syndrome (GTS) and Non-Coeliac Gluten Sensitivity (NCGS) may be associated. We analyse the efficacy of a gluten-free diet (GFD) in 29 patients with GTS (23 children; six adults) in a prospective pilot study. All of them followed a GFD for one year. The Yale Global Tics Severity Scale (YGTSS), the Yale-Brown Obsessive-Compulsive Scale—Self Report (Y-BOCS) or the Children’s Yale-Brown Obsessive-Compulsive Scale—Self Report (CY-BOCS), and the Cavanna’s Quality of Life Questionnaire applied to GTS (GTS-QOL) were compared before and after the GFD; 74% of children and 50% of adults were males, not significant (NS). At the beginning of the study, 69% of children and 100% of adults had associated obsessive-compulsive disorder (OCD) (NS). At baseline, the YGTSS scores were 55.0 ± 17.5 (children) and 55.8 ± 19.8 (adults) (NS), the Y-BOCS/CY-BOCS scores were 15.3, (standard deviation (SD) = 12.3) (children) and 26.8 (9.2) (adults) (p = 0.043), and the GTS-QOL scores were 42.8 ± 18.5 (children) and 64 ± 7.9 (adults) (p = 0.000). NCGS was frequent in both groups, with headaches reported by 47.0% of children and 83.6% of adults (p = 0.001). After one year on a GFD there was a marked reduction in measures of tics (YGTSS) (p = 0.001), and the intensity and frequency of OCD (Y-BOCS/CY-BOCS) (p = 0.001), along with improved generic quality of life (p = 0.001) in children and adults. In conclusion, a GFD maintained for one year in GTS patients led to a marked reduction in tics and OCD both in children and adults.

KEYWORDS:

Gilles de la Tourette syndrome (GTS); children and adults; gluten-free diet; motor and vocal/phonic tics; non-coeliac gluten sensitivity (NCGS); obsessive-compulsive disorder (OCD); one-year adherence

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