Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 54

1.

Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.

Purgatorio R, de Candia M, Catto M, Carrieri A, Pisani L, De Palma A, Toma M, Ivanova OA, Voskressensky LG, Altomare CD.

Eur J Med Chem. 2019 Sep 1;177:414-424. doi: 10.1016/j.ejmech.2019.05.062. Epub 2019 May 28.

PMID:
31158754
2.

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.

Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M, Pisani L, Denora N, Iacobazzi RM, Silman I, Sussman JL, Buron F, Colletier JP, Jean L, Routier S, Renard PY.

Eur J Med Chem. 2019 Apr 15;168:58-77. doi: 10.1016/j.ejmech.2018.12.063. Epub 2019 Feb 13.

3.

Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.

Pisani L, Iacobazzi RM, Catto M, Rullo M, Farina R, Denora N, Cellamare S, Altomare CD.

Eur J Med Chem. 2019 Jan 1;161:292-309. doi: 10.1016/j.ejmech.2018.10.016. Epub 2018 Oct 10.

PMID:
30366255
4.

Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer's Disease.

Piemontese L, Vitucci G, Catto M, Laghezza A, Perna FM, Rullo M, Loiodice F, Capriati V, Solfrizzo M.

Molecules. 2018 Aug 29;23(9). pii: E2182. doi: 10.3390/molecules23092182.

5.

Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity.

Purgatorio R, de Candia M, De Palma A, De Santis F, Pisani L, Campagna F, Cellamare S, Altomare CD, Catto M.

Molecules. 2018 Jun 26;23(7). pii: E1544. doi: 10.3390/molecules23071544.

6.

Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors.

Mangiatordi GF, Trisciuzzi D, Iacobazzi R, Denora N, Pisani L, Catto M, Leonetti F, Alberga D, Nicolotti O.

Chem Biol Drug Des. 2018 Jul;92(1):1161-1170. doi: 10.1111/cbdd.13200. Epub 2018 Apr 27.

PMID:
29633572
7.

Structure-property relationship study of the HPLC enantioselective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase.

Pisani L, Rullo M, Catto M, de Candia M, Carrieri A, Cellamare S, Altomare CD.

J Sep Sci. 2018 Mar;41(6):1376-1384. doi: 10.1002/jssc.201701442.

PMID:
29419937
8.

Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties.

Kallitsakis MG, Carotti A, Catto M, Peperidou A, Hadjipavlou-Litina DJ, Litinas KE.

Open Med Chem J. 2017 Nov 30;11:196-211. doi: 10.2174/1874104501711010196. eCollection 2017.

9.

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds.

Stefanachi A, Leonetti F, Pisani L, Catto M, Carotti A.

Molecules. 2018 Jan 27;23(2). pii: E250. doi: 10.3390/molecules23020250. Review.

10.

Novel chemotypes targeting tubulin at the colchicine binding site and unbiasing P-glycoprotein.

Mangiatordi GF, Trisciuzzi D, Alberga D, Denora N, Iacobazzi RM, Gadaleta D, Catto M, Nicolotti O.

Eur J Med Chem. 2017 Oct 20;139:792-803. doi: 10.1016/j.ejmech.2017.07.037. Epub 2017 Jul 21.

PMID:
28863359
11.

Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl)hydrazone: A water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity.

Pisani L, De Palma A, Giangregorio N, Miniero DV, Pesce P, Nicolotti O, Campagna F, Altomare CD, Catto M.

Eur J Pharm Sci. 2017 Nov 15;109:381-388. doi: 10.1016/j.ejps.2017.08.004. Epub 2017 Aug 9.

PMID:
28801274
12.

Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs.

Napolitano L, Scalise M, Koyioni M, Koutentis P, Catto M, Eberini I, Parravicini C, Palazzolo L, Pisani L, Galluccio M, Console L, Carotti A, Indiveri C.

Biochem Pharmacol. 2017 Nov 1;143:39-52. doi: 10.1016/j.bcp.2017.07.006. Epub 2017 Jul 12.

PMID:
28709952
13.

Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties.

Pisani L, Catto M, De Palma A, Farina R, Cellamare S, Altomare CD.

ChemMedChem. 2017 Aug 22;12(16):1349-1358. doi: 10.1002/cmdc.201700282. Epub 2017 Jun 29.

PMID:
28570763
14.

Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents.

Zoidis G, Sosic A, Da Ros S, Gatto B, Sissi C, Palluotto F, Carotti A, Catto M.

Bioorg Med Chem. 2017 May 1;25(9):2625-2634. doi: 10.1016/j.bmc.2017.03.019. Epub 2017 Mar 11.

PMID:
28342691
15.

3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes.

Park B, Nam JH, Kim JH, Kim HJ, Onnis V, Balboni G, Lee KT, Park JH, Catto M, Carotti A, Lee JY.

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1179-1185. doi: 10.1016/j.bmcl.2017.01.068. Epub 2017 Jan 26.

PMID:
28189420
16.

A rational approach to elucidate human monoamine oxidase molecular selectivity.

Mangiatordi GF, Alberga D, Pisani L, Gadaleta D, Trisciuzzi D, Farina R, Carotti A, Lattanzi G, Catto M, Nicolotti O.

Eur J Pharm Sci. 2017 Apr 1;101:90-99. doi: 10.1016/j.ejps.2017.02.008. Epub 2017 Feb 7.

PMID:
28188911
17.

Mind the Gap! A Journey towards Computational Toxicology.

Mangiatordi GF, Alberga D, Altomare CD, Carotti A, Catto M, Cellamare S, Gadaleta D, Lattanzi G, Leonetti F, Pisani L, Stefanachi A, Trisciuzzi D, Nicolotti O.

Mol Inform. 2016 Sep;35(8-9):294-308. doi: 10.1002/minf.201501017. Epub 2016 Apr 13. Review.

PMID:
27546034
18.

Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIα, G-quadruplex binding and cytotoxic properties.

Palluotto F, Sosic A, Pinato O, Zoidis G, Catto M, Sissi C, Gatto B, Carotti A.

Eur J Med Chem. 2016 Nov 10;123:704-717. doi: 10.1016/j.ejmech.2016.07.063. Epub 2016 Jul 28.

PMID:
27521587
19.

Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.

Pisani L, Farina R, Catto M, Iacobazzi RM, Nicolotti O, Cellamare S, Mangiatordi GF, Denora N, Soto-Otero R, Siragusa L, Altomare CD, Carotti A.

J Med Chem. 2016 Jul 28;59(14):6791-806. doi: 10.1021/acs.jmedchem.6b00562. Epub 2016 Jul 7.

PMID:
27347731
20.

Searching for Multi-Targeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif.

Pisani L, Farina R, Soto-Otero R, Denora N, Mangiatordi GF, Nicolotti O, Mendez-Alvarez E, Altomare CD, Catto M, Carotti A.

Molecules. 2016 Mar 17;21(3):362. doi: 10.3390/molecules21030362.

Supplemental Content

Loading ...
Support Center