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Materials (Basel). 2016 Mar 31;9(4). pii: E263. doi: 10.3390/ma9040263.

Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing.

Author information

1
School of Chemical Sciences, Dublin City University, Dublin 9, Ireland. marcello_iacono@hotmail.com.
2
School of Chemical Sciences, Dublin City University, Dublin 9, Ireland. dconnolly@wit.ie.
3
Department of Science, Pharmaceutical and Molecular Biotechnology Research Centre (PMBRC), Waterford Institute of Technology, Cork Road, Waterford, Ireland. dconnolly@wit.ie.
4
School of Chemical Sciences, Dublin City University, Dublin 9, Ireland. andreasheise@rcsi.ie.
5
Polymer Chemistry and Biopolymer Laboratory, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland. andreasheise@rcsi.ie.

Abstract

Polymers are interesting housing materials for the fabrication of inexpensive monolithic chromatography and solid phase extraction (SPE) devices. Challenges arise when polymeric monoliths are formed in non-conical, cylindrical tubes of larger diameter due to potential monolith detachment from the housing wall resulting in loss of separation performance and mechanical stability. Here, a two-step protocol is applied to ensure formation of robust homogeneous methacrylate monolith in polypropylene (PP) tubing with a diameter of 2.0 mm. Detailed Fourier-transform infrared (FTIR) spectroscopic analysis and Scanning Electron Microscopy (SEM) imaging confirm the successful pre-modification of the tubing wall with an anchoring layer of cross-linked ethylene dimethacrylate (EDMA). Subsequent formation of an EDMA-glycidyl methacrylate (GMA) monolith in the PP tube resulted in a homogeneous monolithic polymer with enhanced mechanical stability as compared to non-anchored monoliths.

KEYWORDS:

monolith anchoring; polymer monoliths; polypropylene housing

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