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Items: 1 to 20 of 357

1.

In Vitro Drug Efficacy Testing Against Trypanosoma brucei.

Kaiser M, Mäser P.

Methods Mol Biol. 2020;2116:781-789. doi: 10.1007/978-1-0716-0294-2_46.

PMID:
32221955
2.

Activity of diphenyl ether benzyl amines against Human African Trypanosomiasis.

Hagen JP, Darner G, Anderson S, Higgins K, Leas DA, Mitra A, Mashinson V, Wol T, Vera-Esquivel C, Belter B, Cal M, Kaiser M, Wallick A, Warner RC, Davis PH.

Bioorg Chem. 2020 Apr;97:103590. doi: 10.1016/j.bioorg.2020.103590. Epub 2020 Jan 27.

PMID:
32179269
3.

Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease.

Harrison JR, Sarkar S, Hampton S, Riley J, Stojanovski L, Sahlberg C, Appelqvist P, Erath J, Mathan V, Rodriguez A, Kaiser M, Pacanowska DG, Read KD, Johansson NG, Gilbert IH.

J Med Chem. 2020 Mar 26;63(6):3066-3089. doi: 10.1021/acs.jmedchem.9b01852. Epub 2020 Mar 5.

PMID:
32134269
4.

Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors.

Ponzi S, Bresciani A, Kaiser M, Nardi V, Nizi E, Ontoria JM, Pace P, Paonessa G, Summa V, Harper S.

Bioorg Med Chem Lett. 2020 Apr 15;30(8):127052. doi: 10.1016/j.bmcl.2020.127052. Epub 2020 Feb 22.

PMID:
32113841
5.

Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis.

Rao SPS, Lakshminarayana SB, Jiricek J, Kaiser M, Ritchie R, Myburgh E, Supek F, Tuntland T, Nagle A, Molteni V, Mäser P, Mottram JC, Barrett MP, Diagana TT.

Trop Med Infect Dis. 2020 Feb 17;5(1). pii: E28. doi: 10.3390/tropicalmed5010028.

6.

Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.

Dawidowski M, Kalel VC, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko IV, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz GM.

J Med Chem. 2020 Jan 23;63(2):847-879. doi: 10.1021/acs.jmedchem.9b01876. Epub 2020 Jan 6.

PMID:
31860309
7.

Antiprotozoal Activity of Turkish Origanum onites Essential Oil and Its Components.

Tasdemir D, Kaiser M, Demirci B, Demirci F, Baser KHC.

Molecules. 2019 Dec 3;24(23). pii: E4421. doi: 10.3390/molecules24234421.

8.

Phototemtide A, a Cyclic Lipopeptide Heterologously Expressed from Photorhabdus temperata Meg1, Shows Selective Antiprotozoal Activity.

Zhao L, Vo TD, Kaiser M, Bode HB.

Chembiochem. 2019 Dec 9. doi: 10.1002/cbic.201900665. [Epub ahead of print]

PMID:
31814269
9.

Structure, Biosynthesis, and Bioactivity of Photoditritide from Photorhabdus temperata Meg1.

Zhao L, Awori RM, Kaiser M, Groß J, Opatz T, Bode HB.

J Nat Prod. 2019 Dec 27;82(12):3499-3503. doi: 10.1021/acs.jnatprod.9b00932. Epub 2019 Dec 4.

PMID:
31799840
10.

Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity.

Pérez-Moreno G, Sánchez-Carrasco P, Ruiz-Pérez LM, Johansson NG, Müller S, Baragaña B, Hampton SE, Gilbert IH, Kaiser M, Sarkar S, Pandurangan T, Kumar V, González-Pacanowska D.

Malar J. 2019 Dec 3;18(1):392. doi: 10.1186/s12936-019-3025-2.

11.

Synthesis, in-vitro antiprotozoal activity and molecular docking study of isothiocyanate derivatives.

Babanezhad Harikandei K, Salehi P, Ebrahimi SN, Bararjanian M, Kaiser M, Al-Harrasi A.

Bioorg Med Chem. 2020 Jan 1;28(1):115185. doi: 10.1016/j.bmc.2019.115185. Epub 2019 Nov 9.

PMID:
31784198
12.

A new chemotype with promise against Trypanosoma cruzi.

Wang X, Cal M, Kaiser M, Buckner FS, Lepesheva GI, Sanford AG, Wallick AI, Davis PH, Vennerstrom JL.

Bioorg Med Chem Lett. 2020 Jan 1;30(1):126778. doi: 10.1016/j.bmcl.2019.126778. Epub 2019 Oct 31.

PMID:
31706668
13.

Structure-Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents.

Bernal FA, Kaiser M, Wünsch B, Schmidt TJ.

ChemMedChem. 2020 Jan 7;15(1):68-78. doi: 10.1002/cmdc.201900544. Epub 2019 Nov 12.

14.

A Near-Complete Series of Four Atropisomeric Jozimine A2-Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from Ancistrocladus abbreviatus.

Fayez S, Li J, Feineis D, Aké Assi L, Kaiser M, Brun R, Anany MA, Wajant H, Bringmann G.

J Nat Prod. 2019 Nov 22;82(11):3033-3046. doi: 10.1021/acs.jnatprod.9b00589. Epub 2019 Oct 23.

PMID:
31642313
15.

Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8'-Coupling Site, from the Congolese Liana Ancistrocladus ealaensis, Targeting Pancreatic Cancer Cells.

Tshitenge DT, Bruhn T, Feineis D, Schmidt D, Mudogo V, Kaiser M, Brun R, Würthner F, Awale S, Bringmann G.

J Nat Prod. 2019 Nov 22;82(11):3150-3164. doi: 10.1021/acs.jnatprod.9b00755. Epub 2019 Oct 20.

PMID:
31630523
16.

Antiprotozoal and antihelminthic properties of plants ingested by wild Japanese macaques (Macaca fuscata yakui) in Yakushima Island.

Tasdemir D, MacIntosh AJJ, Stergiou P, Kaiser M, Mansour NR, Bickle Q, Huffman MA.

J Ethnopharmacol. 2020 Jan 30;247:112270. doi: 10.1016/j.jep.2019.112270. Epub 2019 Oct 4.

PMID:
31589965
17.

(±)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 Isolated from the Halophyte Salicornia sp.

Shi YN, Pusch S, Shi YM, Richter C, Maciá-Vicente JG, Schwalbe H, Kaiser M, Opatz T, Bode HB.

J Org Chem. 2019 Sep 6;84(17):11203-11209. doi: 10.1021/acs.joc.9b01229. Epub 2019 Aug 27.

PMID:
31409073
18.

Targeting a Large Active Site: Structure-Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase.

De Gasparo R, Halgas O, Harangozo D, Kaiser M, Pai EF, Krauth-Siegel RL, Diederich F.

Chemistry. 2019 Sep 2;25(49):11416-11421. doi: 10.1002/chem.201901664. Epub 2019 Aug 13.

PMID:
31407832
19.

N-substituted noscapine derivatives as new antiprotozoal agents: Synthesis, antiparasitic activity and molecular docking study.

Babanezhad Harikandei K, Salehi P, Ebrahimi SN, Bararjanian M, Kaiser M, Khavasi HR, Al-Harrasi A.

Bioorg Chem. 2019 Oct;91:103116. doi: 10.1016/j.bioorg.2019.103116. Epub 2019 Jul 11.

PMID:
31377384
20.

An Unusually Broad Series of Seven Cyclombandakamines, Bridged Dimeric Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ealaensis.

Tshitenge DT, Bruhn T, Feineis D, Mudogo V, Kaiser M, Brun R, Bringmann G.

Sci Rep. 2019 Jul 8;9(1):9812. doi: 10.1038/s41598-019-46336-z.

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