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Items: 1 to 20 of 113


Simplified immunosuppressive and neuroprotective agents based on gracilin A.

Abbasov ME, Alvariño R, Chaheine CM, Alonso E, Sánchez JA, Conner ML, Alfonso A, Jaspars M, Botana LM, Romo D.

Nat Chem. 2019 Apr;11(4):342-350. doi: 10.1038/s41557-019-0230-0. Epub 2019 Mar 22.


Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil.

Carro L, Castro JF, Razmilic V, Nouioui I, Pan C, Igual JM, Jaspars M, Goodfellow M, Bull AT, Asenjo JA, Klenk HP.

Sci Rep. 2019 Mar 18;9(1):4678. doi: 10.1038/s41598-019-38789-z.


LC-HRMS-Database Screening Metrics for Rapid Prioritization of Samples to Accelerate the Discovery of Structurally New Natural Products.

Tabudravu JN, Pellissier L, Smith AJ, Subko K, Autréau C, Feussner K, Hardy D, Butler D, Kidd R, Milton EJ, Deng H, Ebel R, Salonna M, Gissi C, Montesanto F, Kelly SM, Milne BF, Cimpan G, Jaspars M.

J Nat Prod. 2019 Feb 22;82(2):211-220. doi: 10.1021/acs.jnatprod.8b00575. Epub 2019 Feb 8.


Paenidigyamycin A, Potent Antiparasitic Imidazole Alkaloid from the Ghanaian Paenibacillus sp. DE2SH.

Osei E, Kwain S, Mawuli GT, Anang AK, Owusu KB, Camas M, Camas AS, Ohashi M, Alexandru-Crivac CN, Deng H, Jaspars M, Kyeremeh K.

Mar Drugs. 2018 Dec 24;17(1). pii: E9. doi: 10.3390/md17010009.


Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives.

Tortorella E, Tedesco P, Palma Esposito F, January GG, Fani R, Jaspars M, de Pascale D.

Mar Drugs. 2018 Sep 29;16(10). pii: E355. doi: 10.3390/md16100355. Review.


The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis.

Dambuza IM, Drake T, Chapuis A, Zhou X, Correia J, Taylor-Smith L, LeGrave N, Rasmussen T, Fisher MC, Bicanic T, Harrison TS, Jaspars M, May RC, Brown GD, Yuecel R, MacCallum DM, Ballou ER.

PLoS Pathog. 2018 May 18;14(5):e1006978. doi: 10.1371/journal.ppat.1006978. eCollection 2018 May.


Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A.

Copmans D, Rateb M, Tabudravu JN, Pérez-Bonilla M, Dirkx N, Vallorani R, Diaz C, Pérez Del Palacio J, Smith AJ, Ebel R, Reyes F, Jaspars M, de Witte PAM.

ACS Chem Neurosci. 2018 Jul 18;9(7):1652-1662. doi: 10.1021/acschemneuro.8b00060. Epub 2018 Apr 19.


Natural product diversity of actinobacteria in the Atacama Desert.

Rateb ME, Ebel R, Jaspars M.

Antonie Van Leeuwenhoek. 2018 Aug;111(8):1467-1477. doi: 10.1007/s10482-018-1030-z. Epub 2018 Feb 14. Review.


Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil.

Abdelkader MSA, Philippon T, Asenjo JA, Bull AT, Goodfellow M, Ebel R, Jaspars M, Rateb ME.

J Antibiot (Tokyo). 2018 Mar;71(4):425-431. doi: 10.1038/s41429-017-0012-0. Epub 2018 Jan 23.


Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants.

Alexandru-Crivac CN, Umeobika C, Leikoski N, Jokela J, Rickaby KA, Grilo AM, Sjö P, Plowright AT, Idress M, Siebs E, Nneoyi-Egbe A, Wahlsten M, Sivonen K, Jaspars M, Trembleau L, Fewer DP, Houssen WE.

Chem Commun (Camb). 2017 Sep 26;53(77):10656-10659. doi: 10.1039/c7cc05913b.


Dual Induction of New Microbial Secondary Metabolites by Fungal Bacterial Co-cultivation.

Wakefield J, Hassan HM, Jaspars M, Ebel R, Rateb ME.

Front Microbiol. 2017 Jul 11;8:1284. doi: 10.3389/fmicb.2017.01284. eCollection 2017.


A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize.

Booth J, Alexandru-Crivac CN, Rickaby KA, Nneoyiegbe AF, Umeobika U, McEwan AR, Trembleau L, Jaspars M, Houssen WE, Shalashilin DV.

J Phys Chem Lett. 2017 May 18;8(10):2310-2315. doi: 10.1021/acs.jpclett.7b00848. Epub 2017 May 10.


Targeted Dereplication of Microbial Natural Products by High-Resolution MS and Predicted LC Retention Time.

Chervin J, Stierhof M, Tong MH, Peace D, Hansen KØ, Urgast DS, Andersen JH, Yu Y, Ebel R, Kyeremeh K, Paget V, Cimpan G, Wyk AV, Deng H, Jaspars M, Tabudravu JN.

J Nat Prod. 2017 May 26;80(5):1370-1377. doi: 10.1021/acs.jnatprod.6b01035. Epub 2017 Apr 26.


Increased Biological Activity of Aneurinibacillus migulanus Strains Correlates with the Production of New Gramicidin Secondary Metabolites.

Alenezi FN, Rekik I, Chenari Bouket A, Luptakova L, Weitz HJ, Rateb ME, Jaspars M, Woodward S, Belbahri L.

Front Microbiol. 2017 Apr 7;8:517. doi: 10.3389/fmicb.2017.00517. eCollection 2017.


Synthesis of Hybrid Cyclopeptides through Enzymatic Macrocyclization.

Oueis E, Nardone B, Jaspars M, Westwood NJ, Naismith JH.

ChemistryOpen. 2016 Dec 13;6(1):11-14. doi: 10.1002/open.201600134. eCollection 2017 Feb.


Corrigendum: A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway.

Parajuli A, Kwak DH, Dalponte L, Leikoski N, Galica T, Umeobika U, Trembleau L, Bent A, Sivonen K, Wahlsten M, Wang H, Rizzi E, De Bellis G, Naismith J, Jaspars M, Liu X, Houssen W, Fewer DP.

Angew Chem Int Ed Engl. 2017 Jan 9;56(2):433. doi: 10.1002/anie.201609949. No abstract available.


Structure of the cyanobactin oxidase ThcOx from Cyanothece sp. PCC 7425, the first structure to be solved at Diamond Light Source beamline I23 by means of S-SAD.

Bent AF, Mann G, Houssen WE, Mykhaylyk V, Duman R, Thomas L, Jaspars M, Wagner A, Naismith JH.

Acta Crystallogr D Struct Biol. 2016 Nov 1;72(Pt 11):1174-1180. Epub 2016 Oct 28.


Spongionella Secondary Metabolites, Promising Modulators of Immune Response through CD147 Receptor Modulation.

Sánchez JA, Alfonso A, Rodriguez I, Alonso E, Cifuentes JM, Bermudez R, Rateb ME, Jaspars M, Houssen WE, Ebel R, Tabudravu J, Botana LM.

Front Immunol. 2016 Oct 24;7:452. eCollection 2016.


Evaluation of the Antioxidant Activity of the Marine Pyrroloiminoquinone Makaluvamines.

Alonso E, Alvariño R, Leirós M, Tabudravu JN, Feussner K, Dam MA, Rateb ME, Jaspars M, Botana LM.

Mar Drugs. 2016 Oct 27;14(11). pii: E197.


Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics.

Oueis E, Jaspars M, Westwood NJ, Naismith JH.

Angew Chem Weinheim Bergstr Ger. 2016 May 4;128(19):5936-5939. Epub 2016 Apr 5.

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