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Disease Associated Mutations in KIR Proteins Linked to Aberrant Inward Rectifier Channel Trafficking.

Zangerl-Plessl EM, Qile M, Bloothooft M, Stary-Weinzinger A, van der Heyden MAG.

Biomolecules. 2019 Oct 25;9(11). pii: E650. doi: 10.3390/biom9110650. Review.


LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.

Qile M, Beekman HDM, Sprenkeler DJ, Houtman MJC, van Ham WB, Stary-Weinzinger A, Beyl S, Hering S, van den Berg DJ, de Lange ECM, Heitman LH, IJzerman AP, Vos MA, van der Heyden MAG.

Br J Pharmacol. 2019 Oct;176(19):3871-3885. doi: 10.1111/bph.14798. Epub 2019 Aug 30.


Identification of a PEST Sequence in Vertebrate KIR2.1 That Modifies Rectification.

Qile M, Ji Y, Houtman MJC, Veldhuis M, Romunde F, Kok B, van der Heyden MAG.

Front Physiol. 2019 Jul 5;10:863. doi: 10.3389/fphys.2019.00863. eCollection 2019.


Nicotine intoxication by e-cigarette liquids: a study of case reports and pathophysiology.

Maessen GC, Wijnhoven AM, Neijzen RL, Paulus MC, van Heel DAM, Bomers BHA, Boersma LE, Konya B, van der Heyden MAG.

Clin Toxicol (Phila). 2020 Jan;58(1):1-8. doi: 10.1080/15563650.2019.1636994. Epub 2019 Jul 9.


Computational Identification of Novel Kir6 Channel Inhibitors.

Chen X, Garon A, Wieder M, Houtman MJC, Zangerl-Plessl EM, Langer T, van der Heyden MAG, Stary-Weinzinger A.

Front Pharmacol. 2019 May 24;10:549. doi: 10.3389/fphar.2019.00549. eCollection 2019.


Glibenclamide and HMR1098 normalize Cantú syndrome-associated gain-of-function currents.

Houtman MJC, Chen X, Qile M, Duran K, van Haaften G, Stary-Weinzinger A, van der Heyden MAG.

J Cell Mol Med. 2019 Aug;23(8):4962-4969. doi: 10.1111/jcmm.14329. Epub 2019 May 22.


Sex hormones and jumping heart beats.

van der Heyden MAG, Vos MA.

J Cardiovasc Electrophysiol. 2019 Jun;30(6):950-951. doi: 10.1111/jce.13939. Epub 2019 Apr 21. No abstract available.


Commentary: Golgin-97 Targets Ectopically Expressed Inward Rectifying Potassium Channel, Kir2.1, to the Trans-Golgi Network in COS-7 Cells.

Zangerl-Plessl EM, van der Heyden MAG.

Front Physiol. 2018 Oct 5;9:1401. doi: 10.3389/fphys.2018.01401. eCollection 2018. No abstract available.


Editorial: Ion Channel Trafficking and Cardiac Arrhythmias.

van der Heyden MAG, Delisle BP, Abriel H.

Front Physiol. 2018 Sep 25;9:1254. doi: 10.3389/fphys.2018.01254. eCollection 2018. No abstract available.


Efficacy of pentamidine analogue 6 in dogs with chronic atrial fibrillation.

Szatmári V, Ji Y, Herwijnen BV, Feng M, Wang MZ, Bossu A, van der Heyden MAG.

J Vet Intern Med. 2018 Sep;32(5):1549-1554. doi: 10.1111/jvim.15242. Epub 2018 Aug 5.


Short-Lasting Episodes of Torsade de Pointes in the Chronic Atrioventricular Block Dog Model Have a Focal Mechanism, While Longer-Lasting Episodes Are Maintained by Re-Entry.

Vandersickel N, Bossu A, De Neve J, Dunnink A, Meijborg VMF, van der Heyden MAG, Beekman JDM, De Bakker JMT, Vos MA, Panfilov AV.

JACC Clin Electrophysiol. 2017 Dec 26;3(13):1565-1576. doi: 10.1016/j.jacep.2017.06.016. Epub 2017 Dec 18.


Istaroxime, a positive inotropic agent devoid of proarrhythmic properties in sensitive chronic atrioventricular block dogs.

Bossu A, Kostense A, Beekman HDM, Houtman MJC, van der Heyden MAG, Vos MA.

Pharmacol Res. 2018 Jul;133:132-140. doi: 10.1016/j.phrs.2018.05.001. Epub 2018 May 16.


Review of case reports on hyperkalemia induced by dietary intake: not restricted to chronic kidney disease patients.

Te Dorsthorst RPM, Hendrikse J, Vervoorn MT, van Weperen VYH, van der Heyden MAG.

Eur J Clin Nutr. 2019 Jan;73(1):38-45. doi: 10.1038/s41430-018-0154-6. Epub 2018 Mar 27. Review.


Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.

Bossu A, Houtman MJC, Meijborg VMF, Varkevisser R, Beekman HDM, Dunnink A, de Bakker JMT, Mollova N, Rajamani S, Belardinelli L, van der Heyden MAG, Vos MA.

Br J Pharmacol. 2018 Jun;175(12):2470-2482. doi: 10.1111/bph.14217. Epub 2018 May 6.


Cardiac Arrhythmias and Antiarrhythmic Drugs: An Autophagic Perspective.

van Bavel JJA, Vos MA, van der Heyden MAG.

Front Physiol. 2018 Feb 23;9:127. doi: 10.3389/fphys.2018.00127. eCollection 2018.


Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo.

Baburin I, Varkevisser R, Schramm A, Saxena P, Beyl S, Szkokan P, Linder T, Stary-Weinzinger A, van der Heyden MAG, Houtman M, Takanari H, Jonsson M, Beekman JHD, Hamburger M, Vos MA, Hering S.

Pharmacol Res. 2018 May;131:150-163. doi: 10.1016/j.phrs.2018.02.024. Epub 2018 Mar 15.


Response to the letter from Warren et al.

Takanari H, Fontes MSC, van der Heyden MAG, Vos MA, van Veen TAB.

Cardiovasc Res. 2017 Dec 1;113(14):1799-1800. doi: 10.1093/cvr/cvx200. No abstract available.


High-potency block of Kir4.1 channels by pentamidine: Molecular basis.

Aréchiga-Figueroa IA, Marmolejo-Murillo LG, Cui M, Delgado-Ramírez M, van der Heyden MAG, Sánchez-Chapula JA, Rodríguez-Menchaca AA.

Eur J Pharmacol. 2017 Nov 15;815:56-63. doi: 10.1016/j.ejphar.2017.10.009. Epub 2017 Oct 6.


The immature electrophysiological phenotype of iPSC-CMs still hampers in vitro drug screening: Special focus on IK1.

Goversen B, van der Heyden MAG, van Veen TAB, de Boer TP.

Pharmacol Ther. 2018 Mar;183:127-136. doi: 10.1016/j.pharmthera.2017.10.001. Epub 2017 Oct 3. Review.


Commentary: Autonomic Modulation in Patients with Heart Failure Increases Beat-to-Beat Variability of Ventricular Action Potential Duration.

Van Weperen VYH, Vos MA, Van der Heyden MAG.

Front Physiol. 2017 Jun 30;8:459. doi: 10.3389/fphys.2017.00459. eCollection 2017. No abstract available.

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