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Items: 1 to 20 of 28


Synthesis and Antiproliferative Activity of New Cyclodiprenyl Phenols against Select Cancer Cell Lines.

Said B, Montenegro I, Valenzuela M, Olguín Y, Caro N, Werner E, Godoy P, Villena J, Madrid A.

Molecules. 2018 Sep 12;23(9). pii: E2323. doi: 10.3390/molecules23092323.


Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects.

Bravo D, Hoare A, Soto C, Valenzuela MA, Quest AF.

World J Gastroenterol. 2018 Jul 28;24(28):3071-3089. doi: 10.3748/wjg.v24.i28.3071. Review.


Autumn Royal and Ribier Grape Juice Extracts Reduced Viability and Metastatic Potential of Colon Cancer Cells.

Valenzuela M, Bastias L, Montenegro I, Werner E, Madrid A, Godoy P, Párraga M, Villena J.

Evid Based Complement Alternat Med. 2018 Jan 14;2018:2517080. doi: 10.1155/2018/2517080. eCollection 2018.


Helicobacter pylori Induced Phosphatidylinositol-3-OH Kinase/mTOR Activation Increases Hypoxia Inducible Factor-1α to Promote Loss of Cyclin D1 and G0/G1 Cell Cycle Arrest in Human Gastric Cells.

Canales J, Valenzuela M, Bravo J, Cerda-Opazo P, Jorquera C, Toledo H, Bravo D, Quest AF.

Front Cell Infect Microbiol. 2017 Mar 28;7:92. doi: 10.3389/fcimb.2017.00092. eCollection 2017.


Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis.

Costantino VV, Lobos-Gonzalez L, Ibañez J, Fernandez D, Cuello-Carrión FD, Valenzuela MA, Barbieri MA, Semino SN, Jahn GA, Quest AF, Lopez LA.

Cancer Lett. 2016 Mar 1;372(1):10-23. doi: 10.1016/j.canlet.2015.12.004. Epub 2015 Dec 21.


Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis.

Valenzuela MA, Canales J, Corvalán AH, Quest AF.

World J Gastroenterol. 2015 Dec 7;21(45):12742-56. doi: 10.3748/wjg.v21.i45.12742. Review.


Arrest of Viral Proliferation by Ectopic Copies of Its Cognate Replication Origin.

Valenzuela MS, Sharan C.

Genes (Basel). 2015 Jun 23;6(2):436-50. doi: 10.3390/genes6020436.


Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells.

Wehinger S, Ortiz R, Díaz MI, Aguirre A, Valenzuela M, Llanos P, Mc Master C, Leyton L, Quest AF.

Biochim Biophys Acta. 2015 May;1852(5):693-708. doi: 10.1016/j.bbadis.2014.12.021. Epub 2015 Jan 5.


Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription.

Fernández JG, Rodríguez DA, Valenzuela M, Calderon C, Urzúa U, Munroe D, Rosas C, Lemus D, Díaz N, Wright MC, Leyton L, Tapia JC, Quest AF.

Mol Cancer. 2014 Sep 9;13:209. doi: 10.1186/1476-4598-13-209.


AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells.

Sid B, Glorieux C, Valenzuela M, Rommelaere G, Najimi M, Dejeans N, Renard P, Verrax J, Calderon PB.

Biochem Pharmacol. 2014 Sep 15;91(2):168-80. doi: 10.1016/j.bcp.2014.07.010. Epub 2014 Jul 21.


A chromatin structure-based model accurately predicts DNA replication timing in human cells.

Gindin Y, Valenzuela MS, Aladjem MI, Meltzer PS, Bilke S.

Mol Syst Biol. 2014 Mar 28;10:722. doi: 10.1002/msb.134859.


Characterization of the arginine decarboxylase gene (ORF HP0422, speA) involved in acid tolerance in Helicobacter pylori.

Valenzuela M, Cáceres A, Almarza O, Bravo D, Soto S, Cerda O, Toledo H.

Helicobacter. 2014 Jun;19(3):182-93. doi: 10.1111/hel.12115. Epub 2014 Mar 17.


Helicobacter pylori-induced loss of survivin and gastric cell viability is attributable to secreted bacterial gamma-glutamyl transpeptidase activity.

Valenzuela M, Bravo D, Canales J, Sanhueza C, Díaz N, Almarza O, Toledo H, Quest AF.

J Infect Dis. 2013 Oct 1;208(7):1131-41. doi: 10.1093/infdis/jit286. Epub 2013 Jul 11.


Initiation of DNA Replication in the Human Genome.

Valenzuela MS.

Hereditary Genet. 2012 Feb 8;Suppl 1(3). pii: 4903.


Arginine 66 residue of Fur is required for the regulatory function of this protein in the acid adaptation mechanism of Helicobacter pylori.

Toledo H, Villafaena C, Valenzuela M, López-Solís R.

Helicobacter. 2012 Feb;17(1):16-22. doi: 10.1111/j.1523-5378.2011.00893.x.


Broader utilization of origins of DNA replication in cancer cell lines along a 78 kb region of human chromosome 2q34.

Valenzuela MS, Hu L, Lueders J, Walker R, Meltzer PS.

J Cell Biochem. 2012 Jan;113(1):132-40. doi: 10.1002/jcb.23336.


Genome-wide depletion of replication initiation events in highly transcribed regions.

Martin MM, Ryan M, Kim R, Zakas AL, Fu H, Lin CM, Reinhold WC, Davis SR, Bilke S, Liu H, Doroshow JH, Reimers MA, Valenzuela MS, Pommier Y, Meltzer PS, Aladjem MI.

Genome Res. 2011 Nov;21(11):1822-32. doi: 10.1101/gr.124644.111. Epub 2011 Aug 3.


Preferential localization of human origins of DNA replication at the 5'-ends of expressed genes and at evolutionarily conserved DNA sequences.

Valenzuela MS, Chen Y, Davis S, Yang F, Walker RL, Bilke S, Lueders J, Martin MM, Aladjem MI, Massion PP, Meltzer PS.

PLoS One. 2011;6(5):e17308. doi: 10.1371/journal.pone.0017308. Epub 2011 May 13.


Helicobacter pylori exhibits a fur-dependent acid tolerance response.

Valenzuela M, Albar JP, Paradela A, Toledo H.

Helicobacter. 2011 Jun;16(3):189-99. doi: 10.1111/j.1523-5378.2011.00824.x.


Helicobacter pylori-induced loss of the inhibitor-of-apoptosis protein survivin is linked to gastritis and death of human gastric cells.

Valenzuela M, Pérez-Pérez G, Corvalán AH, Carrasco G, Urra H, Bravo D, Toledo H, Quest AF.

J Infect Dis. 2010 Oct 1;202(7):1021-30. doi: 10.1086/656143.


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