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Items: 1 to 20 of 75

1.

Design of new quinolin-2-one-pyrimidine hybrids as sphingosine kinases inhibitors.

Vettorazzi M, Insuasty D, Lima S, Gutiérrez L, Nogueras M, Marchal A, Abonia R, Andújar S, Spiegel S, Cobo J, Enriz RD.

Bioorg Chem. 2020 Jan;94:103414. doi: 10.1016/j.bioorg.2019.103414. Epub 2019 Nov 13.

2.

New chalcone-sulfonamide hybrids exhibiting anticancer and antituberculosis activity.

Castaño LF, Cuartas V, Bernal A, Insuasty A, Guzman J, Vidal O, Rubio V, Puerto G, Lukáč P, Vimberg V, Balíková-Novtoná G, Vannucci L, Janata J, Quiroga J, Abonia R, Nogueras M, Cobo J, Insuasty B.

Eur J Med Chem. 2019 Aug 15;176:50-60. doi: 10.1016/j.ejmech.2019.05.013. Epub 2019 May 7.

PMID:
31096118
3.

Chloro-formyl steroids as precursors for hybrid heterosteroids: synthesis, spectroscopic characterization, and molecular and supramolecular structures.

Almagro L, Nogueras M, Suárez M, Cobo J, Glidewell C.

Acta Crystallogr C Struct Chem. 2018 Dec 1;74(Pt 12):1667-1673. doi: 10.1107/S2053229618015887. Epub 2018 Nov 21.

PMID:
30516151
4.

Design of Two Alternative Routes for the Synthesis of Naftifine and Analogues as Potential Antifungal Agents.

Abonia R, Garay A, Castillo JC, Insuasty B, Quiroga J, Nogueras M, Cobo J, Butassi E, Zacchino S.

Molecules. 2018 Feb 26;23(3). pii: E520. doi: 10.3390/molecules23030520.

5.

A Schmidt rearrangement-mediated synthesis of novel tetrahydro-benzo[1,4]diazepin-5-ones as potential anticancer and antiprotozoal agents.

Insuasty D, Robledo SM, Vélez ID, Cuervo P, Insuasty B, Quiroga J, Nogueras M, Cobo J, Abonia R.

Eur J Med Chem. 2017 Dec 1;141:567-583. doi: 10.1016/j.ejmech.2017.10.024. Epub 2017 Oct 10.

PMID:
29102177
6.

Microwave-Assisted Synthesis of Diversely Substituted Quinoline-Based Dihydropyridopyrimidine and Dihydropyrazolopyridine Hybrids.

Insuasty D, Abonia R, Insuasty B, Quiroga J, Laali KK, Nogueras M, Cobo J.

ACS Comb Sci. 2017 Aug 14;19(8):555-563. doi: 10.1021/acscombsci.7b00091. Epub 2017 Jul 26.

PMID:
28723092
7.

6-(Aryldiazenyl)pyrazolo[1,5-a]pyrimidines as Strategic Intermediates for the Synthesis of Pyrazolo[5,1-b]purines.

Castillo JC, Estupiñan D, Nogueras M, Cobo J, Portilla J.

J Org Chem. 2016 Dec 16;81(24):12364-12373. Epub 2016 Dec 7.

PMID:
27978735
8.

An efficient synthesis of new caffeine-based chalcones, pyrazolines and pyrazolo[3,4-b][1,4]diazepines as potential antimalarial, antitrypanosomal and antileishmanial agents.

Insuasty B, Ramírez J, Becerra D, Echeverry C, Quiroga J, Abonia R, Robledo SM, Vélez ID, Upegui Y, Muñoz JA, Ospina V, Nogueras M, Cobo J.

Eur J Med Chem. 2015 Mar 26;93:401-13. doi: 10.1016/j.ejmech.2015.02.040. Epub 2015 Feb 21.

PMID:
25725376
9.

A new series of antibacterial nitrosopyrimidines: synthesis and structure-activity relationship.

Olivella M, Marchal A, Nogueras M, Melguizo M, Lima B, Tapia A, Feresin GE, Parravicini O, Giannini F, Andujar SA, Cobo J, Enriz RD.

Arch Pharm (Weinheim). 2015 Jan;348(1):68-80. doi: 10.1002/ardp.201400271. Epub 2014 Nov 21.

PMID:
25413501
10.

Synthesis and in vitro antitumor activity of a novel series of 2-pyrazoline derivatives bearing the 4-aryloxy-7-chloroquinoline fragment.

Montoya A, Quiroga J, Abonia R, Nogueras M, Cobo J, Insuasty B.

Molecules. 2014 Nov 14;19(11):18656-75. doi: 10.3390/molecules191118656.

11.

Synthesis of novel polysubstituted (2SR,4RS)-2-heteroaryltetrahydro-1,4-epoxy-1-benzazepines and cis-2-heteroaryl-4-hydroxytetrahydro-1H-1-benzazepines as antiparasitic agents.

Blanco MC, Escobar P, Leal SM, Bahsas A, Cobo J, Nogueras M, Palma A.

Eur J Med Chem. 2014 Oct 30;86:291-309. doi: 10.1016/j.ejmech.2014.08.055. Epub 2014 Aug 17.

PMID:
25173828
12.

Highly efficient and diastereoselective synthesis of new pyrazolylpyrrolizine and pyrazolylpyrrolidine derivates by a three-component domino process.

Quiroga J, Gálvez J, Abonia R, Insuasty B, Ortíz A, Cobo J, Nogueras M.

Molecules. 2014 Apr 4;19(4):4284-300. doi: 10.3390/molecules19044284.

13.

Microwave induced three-component synthesis and antimycobacterial activity of benzopyrazolo[3,4-b]quinolindiones.

Quiroga J, Diaz Y, Bueno J, Insuasty B, Abonia R, Ortiz A, Nogueras M, Cobo J.

Eur J Med Chem. 2014 Mar 3;74:216-24. doi: 10.1016/j.ejmech.2013.12.037. Epub 2014 Jan 4.

PMID:
24463437
14.

Synthesis of novel analogs of 2-pyrazoline obtained from [(7-chloroquinolin-4-yl)amino]chalcones and hydrazine as potential antitumor and antimalarial agents.

Insuasty B, Montoya A, Becerra D, Quiroga J, Abonia R, Robledo S, Vélez ID, Upegui Y, Nogueras M, Cobo J.

Eur J Med Chem. 2013 Sep;67:252-62. doi: 10.1016/j.ejmech.2013.06.049. Epub 2013 Jul 2.

PMID:
23871905
15.

Molecular modeling study of dihydrofolate reductase inhibitors. Molecular dynamics simulations, quantum mechanical calculations, and experimental corroboration.

Tosso RD, Andujar SA, Gutierrez L, Angelina E, Rodríguez R, Nogueras M, Baldoni H, Suvire FD, Cobo J, Enriz RD.

J Chem Inf Model. 2013 Aug 26;53(8):2018-32. doi: 10.1021/ci400178h. Epub 2013 Jul 24.

PMID:
23834278
16.

Synthesis, antifungal and antitumor activity of novel (Z)-5-hetarylmethylidene-1,3-thiazol-4-ones and (z)-5-ethylidene-1,3-thiazol-4-ones.

Insuasty A, Ramírez J, Raimondi M, Echeverry C, Quiroga J, Abonia R, Nogueras M, Cobo J, Rodríguez MV, Zacchino SA, Insuasty B.

Molecules. 2013 May 13;18(5):5482-97. doi: 10.3390/molecules18055482.

17.

Microwave-assisted synthesis of pyrimido[4,5-b][1,6]naphthyridin-4(3H)-ones with potential antitumor activity.

Insuasty B, Becerra D, Quiroga J, Abonia R, Nogueras M, Cobo J.

Eur J Med Chem. 2013 Feb;60:1-9. doi: 10.1016/j.ejmech.2012.11.037. Epub 2012 Dec 4.

PMID:
23279862
18.

Efficient catalyst-free four-component synthesis of novel γ-aminoethers mediated by a Mannich type reaction.

Abonia R, Castillo J, Insuasty B, Quiroga J, Nogueras M, Cobo J.

ACS Comb Sci. 2013 Jan 14;15(1):2-9. doi: 10.1021/co300105t. Epub 2012 Nov 29.

PMID:
23167924
19.

Synthesis of novel quinoline-2-one based chalcones of potential anti-tumor activity.

Abonia R, Insuasty D, Castillo J, Insuasty B, Quiroga J, Nogueras M, Cobo J.

Eur J Med Chem. 2012 Nov;57:29-40. doi: 10.1016/j.ejmech.2012.08.039. Epub 2012 Sep 6.

PMID:
23043766
20.

Structure-activity relationship study of nitrosopyrimidines acting as antifungal agents.

Olivella M, Marchal A, Nogueras M, Sánchez A, Melguizo M, Raimondi M, Zacchino S, Giannini F, Cobo J, Enriz RD.

Bioorg Med Chem. 2012 Oct 15;20(20):6109-22. doi: 10.1016/j.bmc.2012.08.033. Epub 2012 Aug 31.

PMID:
22995772

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