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Items: 18


Impacting Pancreatic Cancer Therapy in Heterotypic in Vitro Organoids and in Vivo Tumors with Specificity-Tuned, NIR-Activable Photoimmunonanoconjugates: Towards Conquering Desmoplasia?

Obaid G, Bano S, Mallidi S, Broekgaarden M, Kuriakose J, Silber Z, Bulin AL, Wang Y, Mai Z, Jin W, Simeone D, Hasan T.

Nano Lett. 2019 Nov 13;19(11):7573-7587. doi: 10.1021/acs.nanolett.9b00859. Epub 2019 Oct 4.


Modulation of redox metabolism negates cancer-associated fibroblasts-induced treatment resistance in a heterotypic 3D culture platform of pancreatic cancer.

Broekgaarden M, Anbil S, Bulin AL, Obaid G, Mai Z, Baglo Y, Rizvi I, Hasan T.

Biomaterials. 2019 Nov;222:119421. doi: 10.1016/j.biomaterials.2019.119421. Epub 2019 Aug 12.


Low dose photodynamic therapy harmonizes with radiation therapy to induce beneficial effects on pancreatic heterocellular spheroids.

Bulin AL, Broekgaarden M, Simeone D, Hasan T.

Oncotarget. 2019 Apr 5;10(27):2625-2643. doi: 10.18632/oncotarget.26780. eCollection 2019 Apr 5.


Neoadjuvant photodynamic therapy augments immediate and prolonged oxaliplatin efficacy in metastatic pancreatic cancer organoids.

Broekgaarden M, Rizvi I, Bulin AL, Petrovic L, Goldschmidt R, Massodi I, Celli JP, Hasan T.

Oncotarget. 2018 Feb 6;9(16):13009-13022. doi: 10.18632/oncotarget.24425. eCollection 2018 Feb 27.


Photodynamic Therapy with Liposomal Zinc Phthalocyanine and Tirapazamine Increases Tumor Cell Death via DNA Damage.

Broekgaarden M, Weijer R, van Wijk AC, Cox RC, Egmond MR, Hoebe R, van Gulik TM, Heger M.

J Biomed Nanotechnol. 2017 Feb;13(2):204-20.


Comprehensive high-throughput image analysis for therapeutic efficacy of architecturally complex heterotypic organoids.

Bulin AL, Broekgaarden M, Hasan T.

Sci Rep. 2017 Nov 30;7(1):16645. doi: 10.1038/s41598-017-16622-9.


Preparation and Practical Applications of 2',7'-Dichlorodihydrofluorescein in Redox Assays.

Reiniers MJ, van Golen RF, Bonnet S, Broekgaarden M, van Gulik TM, Egmond MR, Heger M.

Anal Chem. 2017 Apr 4;89(7):3853-3857. doi: 10.1021/acs.analchem.7b00043. Epub 2017 Mar 15.


Photonanomedicine: a convergence of photodynamic therapy and nanotechnology.

Obaid G, Broekgaarden M, Bulin AL, Huang HC, Kuriakose J, Liu J, Hasan T.

Nanoscale. 2016 Jul 7;8(25):12471-503. doi: 10.1039/c5nr08691d. Epub 2016 Jun 20. Review.


Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells.

Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, Moerland PD, van Kampen AH, van Gulik TM, Heger M.

BMC Cancer. 2015 Dec 26;15:1014. doi: 10.1186/s12885-015-1994-2.


Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy.

Weijer R, Broekgaarden M, Krekorian M, Alles LK, van Wijk AC, Mackaaij C, Verheij J, van der Wal AC, van Gulik TM, Storm G, Heger M.

Oncotarget. 2016 Jan 19;7(3):3341-56. doi: 10.18632/oncotarget.6490.


Assesment of apoptosis induced changes in scattering using optical coherence tomography.

de Bruin DM, Broekgaarden M, van Gemert MJ, Heger M, de la Rosette JJ, Van Leeuwen TG, Faber DJ.

J Biophotonics. 2016 Sep;9(9):913-23. doi: 10.1002/jbio.201500198. Epub 2015 Nov 13.


Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies.

Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M.

Cancer Metastasis Rev. 2015 Dec;34(4):643-90. doi: 10.1007/s10555-015-9588-7. Review.


Inhibition of NF-κB in Tumor Cells Exacerbates Immune Cell Activation Following Photodynamic Therapy.

Broekgaarden M, Kos M, Jurg FA, van Beek AA, van Gulik TM, Heger M.

Int J Mol Sci. 2015 Aug 21;16(8):19960-77. doi: 10.3390/ijms160819960.


The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer.

Heger M, van Golen RF, Broekgaarden M, Michel MC.

Pharmacol Rev. 2013 Dec 24;66(1):222-307. doi: 10.1124/pr.110.004044. Print 2014. Review.


Endovascular laser–tissue interactions and biological responses in relation to endovenous laser therapy.

Heger M, van Golen RF, Broekgaarden M, van den Bos RR, Neumann HA, van Gulik TM, van Gemert MJ.

Lasers Med Sci. 2014 Mar;29(2):405-22. Review.


An overview of three promising mechanical, optical, and biochemical engineering approaches to improve selective photothermolysis of refractory port wine stains.

Aguilar G, Choi B, Broekgaarden M, Yang O, Yang B, Ghasri P, Chen JK, Bezemer R, Nelson JS, van Drooge AM, Wolkerstorfer A, Kelly KM, Heger M.

Ann Biomed Eng. 2012 Feb;40(2):486-506. doi: 10.1007/s10439-011-0436-9. Epub 2011 Oct 21. Review.


Microbial production of natural raspberry ketone.

Beekwilder J, van der Meer IM, Sibbesen O, Broekgaarden M, Qvist I, Mikkelsen JD, Hall RD.

Biotechnol J. 2007 Oct;2(10):1270-9.


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