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Items: 1 to 20 of 96


High-resolution crystal structures of two prototypical β- and γ-herpesviral nuclear egress complexes unravel the determinants of subfamily specificity.

Muller YA, Häge S, Alkhashrom S, Höllriegl T, Weigert S, Dolles S, Hof K, Walzer SA, Egerer-Sieber C, Conrad M, Holst S, Lösing J, Sonntag E, Sticht H, Eichler J, Marschall M.

J Biol Chem. 2020 Jan 24. pii: jbc.RA119.011546. doi: 10.1074/jbc.RA119.011546. [Epub ahead of print]


Phosphosite analysis of the cytomegaloviral mRNA export factor pUL69 reveals serines with critical importance for recruitment of cellular proteins Pin1 and UAP56/URH49.

Thomas M, Müller R, Horn G, Bogdanow B, Imami K, Milbradt J, Steingruber M, Marschall M, Schilling EM, Fossen T, Stamminger T.

J Virol. 2020 Jan 22. pii: JVI.02151-19. doi: 10.1128/JVI.02151-19. [Epub ahead of print]


Differential upregulation of host cell protein kinases by the replication of α-, β- and γ-herpesviruses provides a signature of virus-specific signalling.

Marschall M, Strojan H, Kiener R, Wangen C, Sonntag E, Müller R, Zeitträger I, Wagner S, Stamminger T, Milbradt J, Behrends U, Körber N, Bauer T, Schrödel S, Thirion C, Wagner R, Hutterer C.

J Gen Virol. 2020 Jan 20. doi: 10.1099/jgv.0.001370. [Epub ahead of print]


A highly potent trimeric derivative of artesunate shows promising treatment profiles in experimental models for congenital HCMV infection in vitro and ex vivo.

Jacquet C, Marschall M, Andouard D, El Hamel C, Chianea T, Tsogoeva SB, Hantz S, Alain S.

Antiviral Res. 2019 Dec 20;175:104700. doi: 10.1016/j.antiviral.2019.104700. [Epub ahead of print] No abstract available.


Wedelolactone inhibits human cytomegalovirus replication by targeting distinct steps of the viral replication cycle.

Svrlanska A, Ruhland A, Marschall M, Reuter N, Stamminger T.

Antiviral Res. 2019 Dec 10;174:104677. doi: 10.1016/j.antiviral.2019.104677. [Epub ahead of print]


Artesunate derivative TF27 inhibits replication and pathogenesis of an oncogenic avian alphaherpesvirus.

Bertzbach LD, Conradie AM, Hahn F, Wild M, Marschall M, Kaufer BB.

Antiviral Res. 2019 Nov;171:104606. doi: 10.1016/j.antiviral.2019.104606. Epub 2019 Sep 11.


Patient-Derived Cytomegaloviruses with Different Ganciclovir Sensitivities from UL97 Mutation Retain Their Replication Efficiency and Some Kinase Activity In Vitro.

Wong DD, van Zuylen WJ, Hamilton ST, Steingruber M, Sonntag E, Marschall M, Rawlinson WD.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e02425-18. doi: 10.1128/AAC.02425-18. Print 2019 Sep.


Chemically sulfated polysaccharides from natural sources: Assessment of extraction-sulfation efficiencies, structural features and antiviral activities.

Mukherjee S, Ghosh K, Hahn F, Wangen C, Strojan H, Müller R, Anand N, Ali I, Bera K, Ray B, Hutterer C, Marschall M, Ray S.

Int J Biol Macromol. 2019 Sep 1;136:521-530. doi: 10.1016/j.ijbiomac.2019.05.005. Epub 2019 May 31.


Human cytomegaloviral multifunctional protein kinase pUL97 impairs zebrafish embryonic development and increases mortality.

Cazorla-Vázquez S, Steingruber M, Marschall M, Engel FB.

Sci Rep. 2019 May 10;9(1):7219. doi: 10.1038/s41598-019-43649-x.


Cyclins B1, T1, and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97.

Steingruber M, Keller L, Socher E, Ferre S, Hesse AM, Couté Y, Hahn F, Büscher N, Plachter B, Sticht H, Marschall M.

J Biol Chem. 2019 Apr 12;294(15):6188-6203. doi: 10.1074/jbc.RA118.007049. Epub 2019 Feb 19.


Visible-Light-Driven C-H Oxidation of Cyclic Tertiary Amines: Access to Synthetic Strychnos Alkaloids with Antiviral Activity.

Guryev AA, Hahn F, Marschall M, Tsogoeva SB.

Chemistry. 2019 Mar 15;25(16):4062-4066. doi: 10.1002/chem.201900078. Epub 2019 Mar 1.


Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities.

Karagöz AÇ, Leidenberger M, Hahn F, Hampel F, Friedrich O, Marschall M, Kappes B, Tsogoeva SB.

Bioorg Med Chem. 2019 Jan 1;27(1):110-115. doi: 10.1016/j.bmc.2018.11.018. Epub 2018 Nov 14.


Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication.

Hamilton ST, Hutterer C, Egilmezer E, Steingruber M, Milbradt J, Marschall M, Rawlinson WD.

Placenta. 2018 Dec;72-73:10-19. doi: 10.1016/j.placenta.2018.10.002. Epub 2018 Oct 13.


In vivo proof-of-concept for two experimental antiviral drugs, both directed to cellular targets, using a murine cytomegalovirus model.

Sonntag E, Hahn F, Bertzbach LD, Seyler L, Wangen C, Müller R, Tannig P, Grau B, Baumann M, Zent E, Zischinsky G, Eickhoff J, Kaufer BB, Bäuerle T, Tsogoeva SB, Marschall M.

Antiviral Res. 2019 Jan;161:63-69. doi: 10.1016/j.antiviral.2018.11.008. Epub 2018 Nov 17.


Synthesis of Artemisinin-Estrogen Hybrids Highly Active against HCMV, P. falciparum, and Cervical and Breast Cancer.

Fröhlich T, Kiss A, Wölfling J, Mernyák E, Kulmány ÁE, Minorics R, Zupkó I, Leidenberger M, Friedrich O, Kappes B, Hahn F, Marschall M, Schneider G, Tsogoeva SB.

ACS Med Chem Lett. 2018 Oct 19;9(11):1128-1133. doi: 10.1021/acsmedchemlett.8b00381. eCollection 2018 Nov 8.


Novel cytomegalovirus-inhibitory compounds of the class pyrrolopyridines show a complex pattern of target binding that suggests an unusual mechanism of antiviral activity.

Hahn F, Hutterer C, Henry C, Hamilton ST, Strojan H, Kraut A, Schulte U, Schütz M, Kohrt S, Wangen C, Pfizer J, Couté Y, Rawlinson WD, Strobl S, Marschall M.

Antiviral Res. 2018 Nov;159:84-94. doi: 10.1016/j.antiviral.2018.09.012. Epub 2018 Sep 27.


Synthesis of Novel Hybrids of Quinazoline and Artemisinin with High Activities against Plasmodium falciparum, Human Cytomegalovirus, and Leukemia Cells.

Fröhlich T, Reiter C, Ibrahim MM, Beutel J, Hutterer C, Zeitträger I, Bahsi H, Leidenberger M, Friedrich O, Kappes B, Efferth T, Marschall M, Tsogoeva SB.

ACS Omega. 2017 Jun 30;2(6):2422-2431. doi: 10.1021/acsomega.7b00310. Epub 2017 Jun 1.


Synthesis of Thymoquinone-Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents.

Fröhlich T, Reiter C, Saeed MEM, Hutterer C, Hahn F, Leidenberger M, Friedrich O, Kappes B, Marschall M, Efferth T, Tsogoeva SB.

ACS Med Chem Lett. 2017 Dec 21;9(6):534-539. doi: 10.1021/acsmedchemlett.7b00412. eCollection 2018 Jun 14.


Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin.

Çapcı Karagöz A, Reiter C, Seo EJ, Gruber L, Hahn F, Leidenberger M, Klein V, Hampel F, Friedrich O, Marschall M, Kappes B, Efferth T, Tsogoeva SB.

Bioorg Med Chem. 2018 Jul 23;26(12):3610-3618. doi: 10.1016/j.bmc.2018.05.041. Epub 2018 May 24.


Transmembrane Protein pUL50 of Human Cytomegalovirus Inhibits ISGylation by Downregulating UBE1L.

Lee MK, Kim YJ, Kim YE, Han TH, Milbradt J, Marschall M, Ahn JH.

J Virol. 2018 Jul 17;92(15). pii: e00462-18. doi: 10.1128/JVI.00462-18. Print 2018 Aug 1.

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