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Items: 1 to 20 of 71

1.

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.

Kane M, Rebensburg SV, Takata MA, Zang TM, Yamashita M, Kvaratskhelia M, Bieniasz PD.

Elife. 2018 Aug 7;7. pii: e35738. doi: 10.7554/eLife.35738.

2.

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence.

Zhao XZ, Métifiot M, Kiselev E, Kessl JJ, Maddali K, Marchand C, Kvaratskhelia M, Pommier Y, Burke TR Jr.

Molecules. 2018 Jul 26;23(8). pii: E1858. doi: 10.3390/molecules23081858.

3.

N6-Methyladenosine-binding proteins suppress HIV-1 infectivity and viral production.

Lu W, Tirumuru N, St Gelais C, Koneru PC, Liu C, Kvaratskhelia M, He C, Wu L.

J Biol Chem. 2018 Aug 24;293(34):12992-13005. doi: 10.1074/jbc.RA118.004215. Epub 2018 Jul 5.

PMID:
29976753
4.

Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5.

Panfil AR, Al-Saleem J, Howard CM, Shkriabai N, Kvaratskhelia M, Green PL.

Front Microbiol. 2018 Jan 30;9:80. doi: 10.3389/fmicb.2018.00080. eCollection 2018.

5.

Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing.

Hoyte AC, Jamin AV, Koneru PC, Kobe MJ, Larue RC, Fuchs JR, Engelman AN, Kvaratskhelia M.

J Biol Chem. 2017 Dec 1;292(48):19814-19825. doi: 10.1074/jbc.M117.816645. Epub 2017 Sep 28.

PMID:
28972144
6.

Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells.

Madison MK, Lawson DQ, Elliott J, Ozantürk AN, Koneru PC, Townsend D, Errando M, Kvaratskhelia M, Kutluay SB.

J Virol. 2017 Aug 10;91(17). pii: e00821-17. doi: 10.1128/JVI.00821-17. Print 2017 Sep 1.

7.

Methods for Identifying and Examining HTLV-1 HBZ Post-translational Modifications.

Al-Saleem J, Kvaratskhelia M, Green PL.

Methods Mol Biol. 2017;1582:111-126. doi: 10.1007/978-1-4939-6872-5_9.

PMID:
28357666
8.

The FACT Complex Promotes Avian Leukosis Virus DNA Integration.

Winans S, Larue RC, Abraham CM, Shkriabai N, Skopp A, Winkler D, Kvaratskhelia M, Beemon KL.

J Virol. 2017 Mar 13;91(7). pii: e00082-17. doi: 10.1128/JVI.00082-17. Print 2017 Apr 1.

9.

Dynamic Interconversions of HCV Helicase Binding Modes on the Nucleic Acid Substrate.

Ablenas CJ, Liu HW, Shkriabai N, Kvaratskhelia M, Cosa G, Götte M.

ACS Infect Dis. 2017 Jan 13;3(1):99-109. doi: 10.1021/acsinfecdis.6b00177. Epub 2016 Nov 23.

PMID:
28081608
10.

Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome.

Passos DO, Li M, Yang R, Rebensburg SV, Ghirlando R, Jeon Y, Shkriabai N, Kvaratskhelia M, Craigie R, Lyumkis D.

Science. 2017 Jan 6;355(6320):89-92. doi: 10.1126/science.aah5163.

11.

Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies.

Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, Kvaratskhelia M, Levy R.

Protein Sci. 2016 Nov;25(11):1911-1917. doi: 10.1002/pro.2997. Epub 2016 Aug 17.

12.

Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and Viral RNA Show Extensive Overlap.

Ngure M, Issur M, Shkriabai N, Liu HW, Cosa G, Kvaratskhelia M, Götte M.

ACS Infect Dis. 2016 Nov 11;2(11):839-851. Epub 2016 Oct 5.

PMID:
27676132
13.

A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.

Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E.

J Biol Chem. 2016 Nov 4;291(45):23569-23577. Epub 2016 Sep 19.

14.

Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins.

Kudryashova E, Koneru PC, Kvaratskhelia M, Strömstedt AA, Lu W, Kudryashov DS.

Sci Rep. 2016 Sep 1;6:32499. doi: 10.1038/srep32499.

15.

HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis.

Kessl JJ, Kutluay SB, Townsend D, Rebensburg S, Slaughter A, Larue RC, Shkriabai N, Bakouche N, Fuchs JR, Bieniasz PD, Kvaratskhelia M.

Cell. 2016 Aug 25;166(5):1257-1268.e12. doi: 10.1016/j.cell.2016.07.044.

16.

Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase.

Agharbaoui FE, Hoyte AC, Ferro S, Gitto R, Buemi MR, Fuchs JR, Kvaratskhelia M, De Luca L.

Eur J Med Chem. 2016 Nov 10;123:673-683. doi: 10.1016/j.ejmech.2016.07.077. Epub 2016 Aug 3.

17.

Development of Potent Antiviral Drugs Inspired by Viral Hexameric DNA-Packaging Motors with Revolving Mechanism.

Pi F, Zhao Z, Chelikani V, Yoder K, Kvaratskhelia M, Guo P.

J Virol. 2016 Aug 26;90(18):8036-46. doi: 10.1128/JVI.00508-16. Print 2016 Sep 15. Review.

18.

Use of chemical modification and mass spectrometry to identify substrate-contacting sites in proteinaceous RNase P, a tRNA processing enzyme.

Chen TH, Tanimoto A, Shkriabai N, Kvaratskhelia M, Wysocki V, Gopalan V.

Nucleic Acids Res. 2016 Jun 20;44(11):5344-55. doi: 10.1093/nar/gkw391. Epub 2016 May 10.

19.

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.

Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M.

ACS Chem Biol. 2016 May 20;11(5):1313-21. doi: 10.1021/acschembio.6b00167. Epub 2016 Mar 2.

20.

Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction.

Crowe BL, Larue RC, Yuan C, Hess S, Kvaratskhelia M, Foster MP.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2086-91. doi: 10.1073/pnas.1516813113. Epub 2016 Feb 8.

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