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Items: 1 to 20 of 161

1.

Metabolomics Provide Sensitive Insights into the Impacts of Low Level Environmental Contamination on Fish Health-A Pilot Study.

Long SM, Tull DL, De Souza DP, Kouremenos KA, Dayalan S, McConville MJ, Hassell KL, Pettigrove VJ, Gagnon MM.

Metabolites. 2020 Jan 6;10(1). pii: E24. doi: 10.3390/metabo10010024.

2.

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum.

Dumont L, Richardson MB, van der Peet P, Marapana DS, Triglia T, Dixon MWA, Cowman AF, Williams SJ, Tilley L, McConville MJ, Cobbold SA.

mBio. 2019 Dec 10;10(6). pii: e02060-19. doi: 10.1128/mBio.02060-19.

3.

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance.

Yang T, Yeoh LM, Tutor MV, Dixon MW, McMillan PJ, Xie SC, Bridgford JL, Gillett DL, Duffy MF, Ralph SA, McConville MJ, Tilley L, Cobbold SA.

Cell Rep. 2019 Nov 26;29(9):2917-2928.e5. doi: 10.1016/j.celrep.2019.10.095.

4.

Metabolomic Analysis of Toxoplasma gondii Tachyzoites.

King EFB, Cobbold SA, Uboldi AD, Tonkin CJ, McConville MJ.

Methods Mol Biol. 2020;2071:435-452. doi: 10.1007/978-1-4939-9857-9_22.

PMID:
31758465
5.

Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome.

Kang Y, Anderson AJ, Jackson TD, Palmer CS, De Souza DP, Fujihara KM, Stait T, Frazier AE, Clemons NJ, Tull D, Thorburn DR, McConville MJ, Ryan MT, Stroud DA, Stojanovski D.

Elife. 2019 Nov 4;8. pii: e48828. doi: 10.7554/eLife.48828.

6.

The multifunctional enzyme S-adenosylhomocysteine/methylthioadenosine nucleosidase is a key metabolic enzyme in the virulence of Salmonella enterica var Typhimurium.

Husna AU, Wang N, Wilksch JJ, Newton HJ, Hocking DM, Hay ID, Cobbold SA, Davies MR, McConville MJ, Lithgow T, Strugnell RA.

Biochem J. 2019 Nov 29;476(22):3435-3453. doi: 10.1042/BCJ20190297.

PMID:
31675053
7.

Coxiella burnetii utilizes both glutamate and glucose during infection with glucose uptake mediated by multiple transporters.

Kuba M, Neha N, De Souza DP, Dayalan S, Newson JPM, Tull D, McConville MJ, Sansom FM, Newton HJ.

Biochem J. 2019 Oct 15;476(19):2851-2867. doi: 10.1042/BCJ20190504.

8.

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites.

Sernee MF, Ralton JE, Nero TL, Sobala LF, Kloehn J, Vieira-Lara MA, Cobbold SA, Stanton L, Pires DEV, Hanssen E, Males A, Ward T, Bastidas LM, van der Peet PL, Parker MW, Ascher DB, Williams SJ, Davies GJ, McConville MJ.

Cell Host Microbe. 2019 Sep 11;26(3):385-399.e9. doi: 10.1016/j.chom.2019.08.009.

9.

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages.

De Souza DP, Achuthan A, Lee MK, Binger KJ, Lee MC, Davidson S, Tull DL, McConville MJ, Cook AD, Murphy AJ, Hamilton JA, Fleetwood AJ.

J Clin Invest. 2019 Oct 1;129(10):4239-4244. doi: 10.1172/JCI127597.

10.

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking.

Kennedy K, Cobbold SA, Hanssen E, Birnbaum J, Spillman NJ, McHugh E, Brown H, Tilley L, Spielmann T, McConville MJ, Ralph SA.

PLoS Biol. 2019 Jul 18;17(7):e3000376. doi: 10.1371/journal.pbio.3000376. eCollection 2019 Jul.

11.

Changes in plasma lipids predict pravastatin efficacy in secondary prevention.

Jayawardana KS, Mundra PA, Giles C, Barlow CK, Nestel PJ, Barnes EH, Kirby A, Thompson P, Sullivan DR, Alshehry ZH, Mellett NA, Huynh K, McConville MJ, Zoungas S, Hillis GS, Chalmers J, Woodward M, Marschner IC, Wong G, Kingwell BA, Simes J, Tonkin AM, Meikle PJ; LIPID Study Investigators.

JCI Insight. 2019 Jul 11;4(13). pii: 128438. doi: 10.1172/jci.insight.128438. eCollection 2019 Jul 11.

12.

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.

Bachem A, Makhlouf C, Binger KJ, de Souza DP, Tull D, Hochheiser K, Whitney PG, Fernandez-Ruiz D, Dähling S, Kastenmüller W, Jönsson J, Gressier E, Lew AM, Perdomo C, Kupz A, Figgett W, Mackay F, Oleshansky M, Russ BE, Parish IA, Kallies A, McConville MJ, Turner SJ, Gebhardt T, Bedoui S.

Immunity. 2019 Aug 20;51(2):285-297.e5. doi: 10.1016/j.immuni.2019.06.002. Epub 2019 Jul 1.

PMID:
31272808
13.

Metabolomic profiling of the excretory-secretory products of hookworm and whipworm.

Wangchuk P, Kouremenos K, Eichenberger RM, Pearson M, Susianto A, Wishart DS, McConville MJ, Loukas A.

Metabolomics. 2019 Jun 28;15(7):101. doi: 10.1007/s11306-019-1561-y.

PMID:
31254203
14.

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii.

Yang L, Uboldi AD, Seizova S, Wilde ML, Coffey MJ, Katris NJ, Yamaryo-Botté Y, Kocan M, Bathgate RAD, Stewart RJ, McConville MJ, Thompson PE, Botté CY, Tonkin CJ.

J Biol Chem. 2019 May 31;294(22):8959-8972. doi: 10.1074/jbc.RA118.005491. Epub 2019 Apr 16.

PMID:
30992368
15.

Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome.

Simpfendorfer KR, Wang N, Tull DL, De Souza DP, Nahid A, Mu A, Hocking DM, Pedersen JS, Wijburg OLC, McConville MJ, Strugnell RA.

Mol Med. 2019 Apr 3;25(1):12. doi: 10.1186/s10020-019-0077-2.

16.

Circadian and wake-dependent changes in human plasma polar metabolites during prolonged wakefulness: A preliminary analysis.

Grant LK, Ftouni S, Nijagal B, De Souza DP, Tull D, McConville MJ, Rajaratnam SMW, Lockley SW, Anderson C.

Sci Rep. 2019 Mar 14;9(1):4428. doi: 10.1038/s41598-019-40353-8.

17.

Antibiotic resistance and host immune evasion in Staphylococcus aureus mediated by a metabolic adaptation.

Jiang JH, Bhuiyan MS, Shen HH, Cameron DR, Rupasinghe TWT, Wu CM, Le Brun AP, Kostoulias X, Domene C, Fulcher AJ, McConville MJ, Howden BP, Lieschke GJ, Peleg AY.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3722-3727. doi: 10.1073/pnas.1812066116. Epub 2019 Feb 11.

18.

The tyrosine transporter of Toxoplasma gondii is a member of the newly defined apicomplexan amino acid transporter (ApiAT) family.

Parker KER, Fairweather SJ, Rajendran E, Blume M, McConville MJ, Bröer S, Kirk K, van Dooren GG.

PLoS Pathog. 2019 Feb 11;15(2):e1007577. doi: 10.1371/journal.ppat.1007577. eCollection 2019 Feb.

19.

Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes.

Wangchuk P, Shepherd C, Constantinoiu C, Ryan RYM, Kouremenos KA, Becker L, Jones L, Buitrago G, Giacomin P, Wilson D, Daly N, McConville MJ, Miles JJ, Loukas A.

Infect Immun. 2019 Mar 25;87(4). pii: e00851-18. doi: 10.1128/IAI.00851-18. Print 2019 Apr.

20.

Determining the Mode of Action of Antimalarial Drugs Using Time-Resolved LC-MS-Based Metabolite Profiling.

Cobbold SA, McConville MJ.

Methods Mol Biol. 2019;1859:225-239. doi: 10.1007/978-1-4939-8757-3_12.

PMID:
30421232

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