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Items: 1 to 20 of 90


Characterization of the NLRP1 inflammasome response in bovine species.

Vrentas CE, Boggiatto PM, Olsen SC, Leppla SH, Moayeri M.

Innate Immun. 2019 Nov 11:1753425919886649. doi: 10.1177/1753425919886649. [Epub ahead of print] No abstract available.


Bacillus anthracis lethal toxin, but not edema toxin, increases pulmonary artery pressure and permeability in isolated perfused rat lungs.

Cui X, Xu W, Neupane P, Weiser-Schlesinger A, Weng R, Pockros B, Li Y, Moayeri M, Leppla SH, Fitz Y, Eichacker PQ.

Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1076-H1090. doi: 10.1152/ajpheart.00685.2018. Epub 2019 Feb 15.


A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague.

Tao P, Mahalingam M, Zhu J, Moayeri M, Sha J, Lawrence WS, Leppla SH, Chopra AK, Rao VB.

MBio. 2018 Oct 16;9(5). pii: e01926-18. doi: 10.1128/mBio.01926-18.


Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages.

Amaral EP, Riteau N, Moayeri M, Maier N, Mayer-Barber KD, Pereira RM, Lage SL, Kubler A, Bishai WR, D'Império-Lima MR, Sher A, Andrade BB.

Front Immunol. 2018 Jun 21;9:1427. doi: 10.3389/fimmu.2018.01427. eCollection 2018.


Inflammasomes in livestock and wildlife: Insights into the intersection of pathogens and natural host species.

Vrentas CE, Schaut RG, Boggiatto PM, Olsen SC, Sutterwala FS, Moayeri M.

Vet Immunol Immunopathol. 2018 Jul;201:49-56. doi: 10.1016/j.vetimm.2018.05.008. Epub 2018 May 21. Review.


Small molecule inhibitors of anthrax edema factor.

Jiao GS, Kim S, Moayeri M, Thai A, Cregar-Hernandez L, McKasson L, O'Malley S, Leppla SH, Johnson AT.

Bioorg Med Chem Lett. 2018 Jan 15;28(2):134-139. doi: 10.1016/j.bmcl.2017.11.040. Epub 2017 Nov 24.


Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support.

Suffredini DA, Cui X, Jaswal D, Remy KE, Li Y, Sun J, Solomon SB, Fitz Y, Moayeri M, Leppla S, Eichacker PQ.

Intensive Care Med Exp. 2017 Oct 23;5(1):48. doi: 10.1186/s40635-017-0159-9.


Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport.

Guichard A, Jain P, Moayeri M, Schwartz R, Chin S, Zhu L, Cruz-Moreno B, Liu JZ, Aguilar B, Hollands A, Leppla SH, Nizet V, Bier E.

PLoS Pathog. 2017 Sep 25;13(9):e1006603. doi: 10.1371/journal.ppat.1006603. eCollection 2017 Sep.


Shock and lethality with anthrax edema toxin in rats are associated with reduced arterial responsiveness to phenylephrine and are reversed with adefovir.

Suffredini DA, Li Y, Xu W, Moayeri M, Leppla S, Fitz Y, Cui X, Eichacker PQ.

Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H946-H958. doi: 10.1152/ajpheart.00285.2017. Epub 2017 Sep 8.


A Bivalent Anthrax-Plague Vaccine That Can Protect against Two Tier-1 Bioterror Pathogens, Bacillus anthracis and Yersinia pestis.

Tao P, Mahalingam M, Zhu J, Moayeri M, Kirtley ML, Fitts EC, Andersson JA, Lawrence WS, Leppla SH, Chopra AK, Rao VB.

Front Immunol. 2017 Jun 26;8:687. doi: 10.3389/fimmu.2017.00687. eCollection 2017.


In vivo characterization of an Hfq protein encoded by the Bacillus anthracis virulence plasmid pXO1.

Keefer AB, Asare EK, Pomerantsev AP, Moayeri M, Martens C, Porcella SF, Gottesman S, Leppla SH, Vrentas CE.

BMC Microbiol. 2017 Mar 14;17(1):63. doi: 10.1186/s12866-017-0973-y.


A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection.

Vrentas CE, Moayeri M, Keefer AB, Greaney AJ, Tremblay J, O'Mard D, Leppla SH, Shoemaker CB.

J Biol Chem. 2016 Oct 7;291(41):21596-21606. Epub 2016 Aug 18.


Nitric oxide production contributes to Bacillus anthracis edema toxin-associated arterial hypotension and lethality: ex vivo and in vivo studies in the rat.

Li Y, Cui X, Xu W, Ohanjanian L, Sampath-Kumar H, Suffredini D, Moayeri M, Leppla S, Fitz Y, Eichacker PQ.

Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H781-93. doi: 10.1152/ajpheart.00163.2016. Epub 2016 Jul 22.


Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice.

Moayeri M, Tremblay JM, Debatis M, Dmitriev IP, Kashentseva EA, Yeh AJ, Cheung GY, Curiel DT, Leppla S, Shoemaker CB.

Clin Vaccine Immunol. 2016 Jan 6;23(3):213-8. doi: 10.1128/CVI.00611-15.


Bacterial Exotoxins and the Inflammasome.

Greaney AJ, Leppla SH, Moayeri M.

Front Immunol. 2015 Nov 10;6:570. doi: 10.3389/fimmu.2015.00570. eCollection 2015. Review.


Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism.

Greaney AJ, Maier NK, Leppla SH, Moayeri M.

J Leukoc Biol. 2016 Jan;99(1):189-99. doi: 10.1189/jlb.3A0415-155RR. Epub 2015 Aug 12.


Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis.

Andrade BB, Pavan Kumar N, Amaral EP, Riteau N, Mayer-Barber KD, Tosh KW, Maier N, Conceição EL, Kubler A, Sridhar R, Banurekha VV, Jawahar MS, Barbosa T, Manganiello VC, Moss J, Fontana JR, Marciano BE, Sampaio EP, Olivier KN, Holland SM, Jackson SH, Moayeri M, Leppla S, Sereti I, Barber DL, Nutman TB, Babu S, Sher A.

J Immunol. 2015 Sep 15;195(6):2763-73. doi: 10.4049/jimmunol.1500942. Epub 2015 Aug 12.


Anthrax Pathogenesis.

Moayeri M, Leppla SH, Vrentas C, Pomerantsev AP, Liu S.

Annu Rev Microbiol. 2015;69:185-208. doi: 10.1146/annurev-micro-091014-104523. Epub 2015 Jul 16. Review.


Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines.

Remy KE, Cui X, Li Y, Sun J, Solomon SB, Fitz Y, Barochia AV, Al-Hamad M, Moayeri M, Leppla SH, Eichacker PQ.

Intensive Care Med Exp. 2015 Dec;3(1):9. doi: 10.1186/s40635-015-0043-4. Epub 2015 Feb 28.


The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes.

Maier NK, Leppla SH, Moayeri M.

J Immunol. 2015 Mar 15;194(6):2776-85. doi: 10.4049/jimmunol.1401611. Epub 2015 Feb 13.

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