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Farmaco. 2002 Aug;57(8):613-7.

Novel synthesis and antifungal activity of pyrrole and pyrrolo[2,3-d]pyrimidine derivatives containing sulfonamido moieties.

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Department of Chemistry, Faculty of Science, Al-Azhar University at Assiut, Egypt.


Several sulfonamides containing pyrroles (2a-c, 6a-d, 8a-d), pyrrolo[2,3-d] pyrimidines (3a-c), acetanilides (11a-c) and tetrahydrobenzothiophenes (13a-c) were synthesized starting from N4-chloroacetylsulfanilamides (1a-d). The structures of synthesized compounds were elucidated by elemental analyses and spectral data. Compounds 2b, 3b, 6b, 8b and 8d exhibited a remarkable antifungal activity compared with the standard fungicide mycostatine.

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