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Vitamin K, Vascular Calcification, and Chronic Kidney Disease: Current Evidence and Unanswered Questions.

Shea MK, Booth SL.

Curr Dev Nutr. 2019 Jul 4;3(9):nzz077. doi: 10.1093/cdn/nzz077. eCollection 2019 Sep. Review.


The microbial metagenome and bone tissue composition in mice with microbiome-induced reductions in bone strength.

Guss JD, Taylor E, Rouse Z, Roubert S, Higgins CH, Thomas CJ, Baker SP, Vashishth D, Donnelly E, Shea MK, Booth SL, Bicalho RC, Hernandez CJ.

Bone. 2019 Oct;127:146-154. doi: 10.1016/j.bone.2019.06.010. Epub 2019 Jun 14.


Vitamin K status and mobility limitation and disability in older adults: The Health, Aging, and Body Composition Study.

Shea MK, Kritchevsky SB, Loeser RF, Booth SL.

J Gerontol A Biol Sci Med Sci. 2019 May 6. pii: glz108. doi: 10.1093/gerona/glz108. [Epub ahead of print]


Atorvastatin Decreases Renal Menaquinone-4 Formation in C57BL/6 Male Mice.

Harshman SG, Shea MK, Fu X, Grusak MA, Smith D, Lamon-Fava S, Kuliopulos A, Greenberg A, Booth SL.

J Nutr. 2019 Mar 1;149(3):416-421. doi: 10.1093/jn/nxy290.


The effect of vitamin D supplementation on lower-extremity power and function in older adults: a randomized controlled trial.

Shea MK, Fielding RA, Dawson-Hughes B.

Am J Clin Nutr. 2019 Feb 1;109(2):369-379. doi: 10.1093/ajcn/nqy290.


Incremental Elevations in TNFα and IL6 in the Human Colon and Procancerous Changes in the Mucosal Transcriptome Accompany Adiposity.

Pfalzer AC, Leung K, Crott JW, Kim SJ, Tai AK, Parnell LD, Kamanu FK, Liu Z, Rogers G, Shea MK, Garcia PE, Mason JB.

Cancer Epidemiol Biomarkers Prev. 2018 Dec;27(12):1416-1423. doi: 10.1158/1055-9965.EPI-18-0121. Epub 2018 Oct 5.


Vitamin D Status and Exercise Capacity in Older Patients with Heart Failure with Preserved Ejection Fraction.

Pandey A, Kitzman DW, Houston DK, Chen H, Shea MK.

Am J Med. 2018 Dec;131(12):1515.e11-1515.e19. doi: 10.1016/j.amjmed.2018.07.009. Epub 2018 Aug 1.


Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.

Jiang X, O'Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Völzke H, Zhou A, Power C, McCarthy MI, Michos ED, Boerwinkle E, Weinstein SJ, Freedman ND, Huang WY, Van Schoor NM, van der Velde N, Groot LCPGM, Enneman A, Cupples LA, Booth SL, Vasan RS, Liu CT, Zhou Y, Ripatti S, Ohlsson C, Vandenput L, Lorentzon M, Eriksson JG, Shea MK, Houston DK, Kritchevsky SB, Liu Y, Lohman KK, Ferrucci L, Peacock M, Gieger C, Beekman M, Slagboom E, Deelen J, Heemst DV, Kleber ME, März W, de Boer IH, Wood AC, Rotter JI, Rich SS, Robinson-Cohen C, den Heijer M, Jarvelin MR, Cavadino A, Joshi PK, Wilson JF, Hayward C, Lind L, Michaëlsson K, Trompet S, Zillikens MC, Uitterlinden AG, Rivadeneira F, Broer L, Zgaga L, Campbell H, Theodoratou E, Farrington SM, Timofeeva M, Dunlop MG, Valdes AM, Tikkanen E, Lehtimäki T, Lyytikäinen LP, Kähönen M, Raitakari OT, Mikkilä V, Ikram MA, Sattar N, Jukema JW, Wareham NJ, Langenberg C, Forouhi NG, Gundersen TE, Khaw KT, Butterworth AS, Danesh J, Spector T, Wang TJ, Hyppönen E, Kraft P, Kiel DP.

Nat Commun. 2018 Jan 17;9(1):260. doi: 10.1038/s41467-017-02662-2.


Association of Urinary Citrate With Acid-Base Status, Bone Resorption, and Calcium Excretion in Older Men and Women.

Shea MK, Dawson-Hughes B.

J Clin Endocrinol Metab. 2018 Feb 1;103(2):452-459. doi: 10.1210/jc.2017-01778.


Association of Vitamin K Status Combined With Vitamin D Status and Lower-Extremity Function: A Prospective Analysis of Two Knee Osteoarthritis Cohorts.

Shea MK, Loeser RF, McAlindon TE, Houston DK, Kritchevsky SB, Booth SL.

Arthritis Care Res (Hoboken). 2018 Aug;70(8):1150-1159. doi: 10.1002/acr.23451. Epub 2018 May 29.


Circulating Vitamin K Is Inversely Associated with Incident Cardiovascular Disease Risk among Those Treated for Hypertension in the Health, Aging, and Body Composition Study (Health ABC).

Shea MK, Booth SL, Weiner DE, Brinkley TE, Kanaya AM, Murphy RA, Simonsick EM, Wassel CL, Vermeer C, Kritchevsky SB; Health ABC Study.

J Nutr. 2017 May;147(5):888-895. doi: 10.3945/jn.117.249375. Epub 2017 Mar 29.


Reducing Undercarboxylated Osteocalcin With Vitamin K Supplementation Does Not Promote Lean Tissue Loss or Fat Gain Over 3 Years in Older Women and Men: A Randomized Controlled Trial.

Shea MK, Dawson-Hughes B, Gundberg CM, Booth SL.

J Bone Miner Res. 2017 Feb;32(2):243-249. doi: 10.1002/jbmr.2989. Epub 2016 Oct 31.


Vitamin K-Dependent Protein Activity and Incident Ischemic Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.

Danziger J, Young RL, Shea MK, Tracy RP, Ix JH, Jenny NS, Mukamal KJ.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):1037-42. doi: 10.1161/ATVBAHA.116.307273. Epub 2016 Mar 31.


Concepts and Controversies in Evaluating Vitamin K Status in Population-Based Studies.

Shea MK, Booth SL.

Nutrients. 2016 Jan 2;8(1). pii: E8. doi: 10.3390/nu8010008. Review.


Vitamin K Status and Lower Extremity Function in Older Adults: The Health Aging and Body Composition Study.

Shea MK, Loeser RF, Hsu FC, Booth SL, Nevitt M, Simonsick EM, Strotmeyer ES, Vermeer C, Kritchevsky SB; Health ABC Study.

J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1348-55. doi: 10.1093/gerona/glv209. Epub 2015 Nov 17.


Inhibiting the progression of arterial calcification with vitamin K in HemoDialysis patients (iPACK-HD) trial: rationale and study design for a randomized trial of vitamin K in patients with end stage kidney disease.

Holden RM, Booth SL, Day AG, Clase CM, Zimmerman D, Moist L, Shea MK, McCabe KM, Jamal SA, Tobe S, Weinstein J, Madhumathi R, Adams MA, Heyland DK.

Can J Kidney Health Dis. 2015 May 1;2:17. doi: 10.1186/s40697-015-0053-x. eCollection 2015.


Potassium Bicarbonate Supplementation Lowers Bone Turnover and Calcium Excretion in Older Men and Women: A Randomized Dose-Finding Trial.

Dawson-Hughes B, Harris SS, Palermo NJ, Gilhooly CH, Shea MK, Fielding RA, Ceglia L.

J Bone Miner Res. 2015 Nov;30(11):2103-11. doi: 10.1002/jbmr.2554. Epub 2015 Jul 28.


Osteocalcin carboxylation is not associated with body weight or percent fat changes during weight loss in post-menopausal women.

Centi AJ, Booth SL, Gundberg CM, Saltzman E, Nicklas B, Shea MK.

Endocrine. 2015 Dec;50(3):627-32. doi: 10.1007/s12020-015-0618-6. Epub 2015 May 12.


Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials.

Kritchevsky SB, Beavers KM, Miller ME, Shea MK, Houston DK, Kitzman DW, Nicklas BJ.

PLoS One. 2015 Mar 20;10(3):e0121993. doi: 10.1371/journal.pone.0121993. eCollection 2015.

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