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Curr Med Chem. 2019 Aug 16. doi: 10.2174/0929867326666190816225348. [Epub ahead of print]

Chemical Mediators Expression Associated with the Modulation of Pain in Rheumatoid Arthritis.

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División de Neurociencias, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra" (INR) Secretaría de Salud (SSA), CDMX,. Mexico.
Escuela Superior de Medicina, Instituto Politécnico Nacional (IPN), CDMX,. Mexico.
División de Enfermedades Musculoesqueléticas y Reumáticas, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra" (INR) Secretaría de Salud (SSA), CDMX, . Mexico.


The management of pain in patients with rheumatoid arthritis (RA) is a complex subject due to the autoimmune nature of the pathology, on the other hand, studies shows that chemical mediators play a fundamental role in the determination, susceptibility and modulation of pain at different levels of the central and peripheral nervous system, resulting in interesting novel molecular targets to mitigate pain in patients with RA. However, due to the complexity of pain physiology in RA and the many chemical mediators, the results of several studies are controversial. <p></p> Objective: The aim is to identify the chemical mediators that are able to modulate the perception of pain in RA. <p></p> Method: In this review, a search was conducted on PubMed, ProQuest, EBSCO, and the Science Citation index for studies that evaluate the expression of chemical mediators on the modulation of pain in RA. <p></p> Results: Few studies have highlighted the importance of the expression of chemical mediators that modulate pain in patients with rheumatoid arthritis. The expression of TRPV1, ASIC-3, TDV8 encode ionic channels in RA and modulate the pain, likewise, the transcription factors in RA, such as TNFα, TGF-β1, IL-6, IL-10, IFN-γ, IL-1b, mTOR, p21, caspase 3, EDNRB, CGRP-CALCB, CGRP-CALCA, TAC1 are also directly involved in pain perception. <p></p> Conclusion: The expression of all chemical mediators are directly related to RA and the modulation of pain by a complex intra and extracellular signaling pathway, however, transcription factors are involved in acute pain, while the ionic channels are involved in chronic pain in RA. <p></p>.


Chemical Mediators; Ionic Channels; Nociception ; Pain; Rheumatoid Arthritis; Transcription Factors

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