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Identification of Functional and Druggable Sites in Aspergillus fumigatus Essential Phosphatases by Virtual Screening.

Thornton BP, Johns A, Al-Shidhani R, Álvarez-Carretero S, Storer ISR, Bromley MJ, Tabernero L.

Int J Mol Sci. 2019 Sep 19;20(18). pii: E4636. doi: 10.3390/ijms20184636.


Kinetic Modeling of DUSP Regulation in Herceptin-Resistant HER2-Positive Breast Cancer.

Buiga P, Elson A, Tabernero L, Schwartz JM.

Genes (Basel). 2019 Jul 26;10(8). pii: E568. doi: 10.3390/genes10080568.


Mechanism of catalysis and inhibition of Mycobacterium tuberculosis SapM, implications for the development of novel antivirulence drugs.

Fernandez-Soto P, Bruce AJE, Fielding AJ, Cavet JS, Tabernero L.

Sci Rep. 2019 Jul 16;9(1):10315. doi: 10.1038/s41598-019-46731-6.


Modelling the role of dual specificity phosphatases in herceptin resistant breast cancer cell lines.

Buiga P, Elson A, Tabernero L, Schwartz JM.

Comput Biol Chem. 2019 Jun;80:138-146. doi: 10.1016/j.compbiolchem.2019.03.018. Epub 2019 Mar 25.


Identification and functional analysis of a novel oculocerebrorenal syndrome of Lowe (OCRL) gene variant in two pedigrees with varying phenotypes including isolated congenital cataract.

Shalaby AK, Emery-Billcliff P, Baralle D, Dabir T, Begum S, Waller S, Tabernero L, Lowe M, Self J.

Mol Vis. 2018 Dec 31;24:847-852. eCollection 2018.


Characteristics of the First Protein Tyrosine Phosphatase with Phytase Activity from a Soil Metagenome.

Castillo Villamizar GA, Nacke H, Griese L, Tabernero L, Funkner K, Daniel R.

Genes (Basel). 2019 Jan 29;10(2). pii: E101. doi: 10.3390/genes10020101.


Characterization of the atypical Ppz/Hal3 phosphatase system from the pathogenic fungus Cryptococcus neoformans.

Zhang C, García-Rodas R, Molero C, de Oliveira HC, Tabernero L, Reverter D, Zaragoza O, Ariño J.

Mol Microbiol. 2019 Apr;111(4):898-917. doi: 10.1111/mmi.14181. Epub 2019 Mar 18.


Dissecting the role of His domain protein tyrosine phosphatase/PTPN23 and ESCRTs in sorting activated epidermal growth factor receptor to the multivesicular body.

Tabernero L, Woodman P.

Biochem Soc Trans. 2018 Oct 19;46(5):1037-1046. doi: 10.1042/BST20170443. Epub 2018 Sep 6. Review.


Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo.

Vickers CF, Silva APG, Chakraborty A, Fernandez P, Kurepina N, Saville C, Naranjo Y, Pons M, Schnettger LS, Gutierrez MG, Park S, Kreiswith BN, Perlin DS, Thomas EJ, Cavet JS, Tabernero L.

J Med Chem. 2018 Sep 27;61(18):8337-8352. doi: 10.1021/acs.jmedchem.8b00832. Epub 2018 Sep 10.


Regulation of dual specificity phosphatases in breast cancer during initial treatment with Herceptin: a Boolean model analysis.

Buiga P, Elson A, Tabernero L, Schwartz JM.

BMC Syst Biol. 2018 Apr 11;12(Suppl 1):11. doi: 10.1186/s12918-018-0534-5.


VSpipe, an Integrated Resource for Virtual Screening and Hit Selection: Applications to Protein Tyrosine Phospahatase Inhibition.

Álvarez-Carretero S, Pavlopoulou N, Adams J, Gilsenan J, Tabernero L.

Molecules. 2018 Feb 7;23(2). pii: E353. doi: 10.3390/molecules23020353.


The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function.

Gahloth D, Heaven G, Jowitt TA, Mould AP, Bella J, Baldock C, Woodman P, Tabernero L.

Sci Rep. 2017 Aug 22;7(1):9151. doi: 10.1038/s41598-017-09467-9.


Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP.

Gahloth D, Levy C, Walker L, Wunderley L, Mould AP, Taylor S, Woodman P, Tabernero L.

Structure. 2017 Jul 5;25(7):1011-1024.e4. doi: 10.1016/j.str.2017.05.005. Epub 2017 Jun 8.


Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1.

Gahloth D, Levy C, Heaven G, Stefani F, Wunderley L, Mould P, Cliff MJ, Bella J, Fielding AJ, Woodman P, Tabernero L.

Structure. 2016 Dec 6;24(12):2115-2126. doi: 10.1016/j.str.2016.10.006. Epub 2016 Nov 10.


Crystallization of PTP Domains.

Levy C, Adams J, Tabernero L.

Methods Mol Biol. 2016;1447:155-80. doi: 10.1007/978-1-4939-3746-2_10.


Cadherin flexibility provides a key difference between desmosomes and adherens junctions.

Tariq H, Bella J, Jowitt TA, Holmes DF, Rouhi M, Nie Z, Baldock C, Garrod D, Tabernero L.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5395-400. doi: 10.1073/pnas.1420508112. Epub 2015 Apr 8.


Hyper-adhesion: a unique property of desmosomes.

Garrod D, Tabernero L.

Cell Commun Adhes. 2014 Oct;21(5):249-56. doi: 10.3109/15419061.2014.930133. Epub 2014 Jun 30. Review.


The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex.

Wunderley L, Brownhill K, Stefani F, Tabernero L, Woodman P.

J Cell Sci. 2014 Feb 1;127(Pt 3):663-72. doi: 10.1242/jcs.140673. Epub 2013 Nov 27.


Dual-specificity phosphatases as molecular targets for inhibition in human disease.

Ríos P, Nunes-Xavier CE, Tabernero L, Köhn M, Pulido R.

Antioxid Redox Signal. 2014 May 10;20(14):2251-73. doi: 10.1089/ars.2013.5709. Epub 2014 Mar 11. Review.


Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.

Böhmer F, Szedlacsek S, Tabernero L, Ostman A, den Hertog J.

FEBS J. 2013 Jan;280(2):413-31. doi: 10.1111/j.1742-4658.2012.08655.x. Epub 2012 Jul 2. Review.

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