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Antioxidants (Basel). 2019 Oct 29;8(11). pii: E517. doi: 10.3390/antiox8110517.

Antiplatelet Activity of Natural Bioactive Extracts from Mango (Mangifera Indica L.) and its By-Products.

Author information

1
Area of Food Technology, Regional Institute for Applied Scientific Research (IRICA), University of Castilla-La Mancha. Avda. Camilo José Cela, 10, 13071 Ciudad Real, Spain. mariaelena.alanon@uclm.es.
2
Department of Analytical Chemistry, Faculty of Sciences, University of Granada, C/Fuentenueva s/n, 18071 Granada, Spain. mariaelena.alanon@uclm.es.
3
Research and Development of Functional Food Centre (CIDAF), PTS Granada, Avda. Del Conocimiento 37, Bioregión Building, 18016 Granada, Spain. mariaelena.alanon@uclm.es.
4
Thrombosis Research Center, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences, Interdisciplinary Center on Aging (CIE), University of Talca, 3460000 Talca, Chile. ipalomo@utalca.cl.
5
Thrombosis Research Center, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences, Interdisciplinary Center on Aging (CIE), University of Talca, 3460000 Talca, Chile. Lyannerodriguez89@gmail.com.
6
Thrombosis Research Center, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences, Interdisciplinary Center on Aging (CIE), University of Talca, 3460000 Talca, Chile. efuentes@utalca.cl.
7
Department of Analytical Chemistry, Faculty of Sciences, University of Granada, C/Fuentenueva s/n, 18071 Granada, Spain. darraez@ugr.es.
8
Research and Development of Functional Food Centre (CIDAF), PTS Granada, Avda. Del Conocimiento 37, Bioregión Building, 18016 Granada, Spain. darraez@ugr.es.
9
Department of Analytical Chemistry, Faculty of Sciences, University of Granada, C/Fuentenueva s/n, 18071 Granada, Spain. ansegura@ugr.es.
10
Research and Development of Functional Food Centre (CIDAF), PTS Granada, Avda. Del Conocimiento 37, Bioregión Building, 18016 Granada, Spain. ansegura@ugr.es.

Abstract

The potential antiplatelet aggregation effects of mango pulp and its by-products (peel, husk seed, and seed) due to the presence of bioactive compounds were explored. Among them, mango seed exhibited a 72% percentage inhibition of platelet aggregation induced by adenosine 5'-diphosphate (ADP) agonist with a demonstrated dose-dependent effect. This biological feature could be caused by the chemical differences in phenolic composition. Mango seed was especially rich in monogalloyl compounds, tetra- and penta-galloylglucose, ellagic acid, mangiferin, and benzophenones such as maclurin derivatives and iriflophenone glucoside. Mangiferin showed an inhibitory effect of 31%, suggesting its key role as one of the main contributors to the antiplatelet activity of mango seed. Therefore, mango seed could be postulated as a natural source of bioactive compounds with antiplatelet properties to design functional foods or complementary therapeutic treatments.

KEYWORDS:

HPLC-DAD-q-TOF-MS; Mango; antiplatelet activity; bioactive compounds; by-products

PMID:
31671743
DOI:
10.3390/antiox8110517
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