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Items: 1 to 20 of 46

1.

Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease.

Hostalkova A, Marikova J, Opletal L, Korabecny J, Hulcova D, Kunes J, Novakova L, Perez DI, Jun D, Kucera T, Andrisano V, Siatka T, Cahlikova L.

J Nat Prod. 2019 Jan 31. doi: 10.1021/acs.jnatprod.8b00592. [Epub ahead of print]

PMID:
30701972
2.

Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors.

Hulcová D, Breiterová K, Siatka T, Klímová K, Davani L, Šafratová M, Hošťálková A, De Simone A, Andrisano V, Cahlíková L.

Molecules. 2018 Mar 21;23(4). pii: E719. doi: 10.3390/molecules23040719.

3.

Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells.

Habartova K, Havelek R, Seifrtova M, Kralovec K, Cahlikova L, Chlebek J, Cermakova E, Mazankova N, Marikova J, Kunes J, Novakova L, Rezacova M.

Sci Rep. 2018 Mar 19;8(1):4829. doi: 10.1038/s41598-018-22862-0.

4.

Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity.

Šafratová M, Hošťálková A, Hulcová D, Breiterová K, Hrabcová V, Machado M, Fontinha D, Prudêncio M, Kuneš J, Chlebek J, Jun D, Hrabinová M, Nováková L, Havelek R, Seifrtová M, Opletal L, Cahlíková L.

Arch Pharm Res. 2018 Feb;41(2):208-218. doi: 10.1007/s12272-017-1000-4. Epub 2017 Dec 14.

PMID:
29243039
5.

Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells.

Seifrtová M, Havelek R, Cahlíková L, Hulcová D, Mazánková N, Řezáčová M.

Phytomedicine. 2017 Nov 15;35:1-10. doi: 10.1016/j.phymed.2017.08.019. Epub 2017 Aug 19.

PMID:
28991639
6.

Anticancer potential of Amaryllidaceae alkaloids evaluated by screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice.

Havelek R, Muthna D, Tomsik P, Kralovec K, Seifrtova M, Cahlikova L, Hostalkova A, Safratova M, Perwein M, Cermakova E, Rezacova M.

Chem Biol Interact. 2017 Sep 25;275:121-132. doi: 10.1016/j.cbi.2017.07.018. Epub 2017 Jul 26.

PMID:
28756149
7.

Cholinesterase and Prolyl Oligopeptidase Inhibitory Activities of Alkaloids from Argemone platyceras (Papaveraceae).

Siatka T, Adamcová M, Opletal L, Cahlíková L, Jun D, Hrabinová M, Kuneš J, Chlebek J.

Molecules. 2017 Jul 14;22(7). pii: E1181. doi: 10.3390/molecules22071181.

8.

Effect of aqueous extract and anthocyanins of calyces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease.

Ali BH, Cahliková L, Opletal L, Karaca T, Manoj P, Ramkumar A, Al Suleimani YM, Al Za'abi M, Nemmar A, Chocholousova-Havlikova L, Locarek M, Siatka T, Blunden G.

J Pharm Pharmacol. 2017 Sep;69(9):1219-1229. doi: 10.1111/jphp.12748. Epub 2017 May 23.

PMID:
28542915
9.

AKR1C3 Inhibitory Potency of Naturally-occurring Amaryllidaceae Alkaloids of Different Structural Types.

Hulcová D, Breiterová K, Zemanová L, Siatkac T, Šafratová M, Vaněčková N, Hošt'fálková A, Wsól V, Cahliková L.

Nat Prod Commun. 2017 Feb;12(2):245-246.

PMID:
30428222
10.

Preparation and Validated Analysis of Anthocyanin Concentrate from the Calyces of Hibiscus sabdariffa.

Opletala L, Chocholousova-Havlikova L, Siatka T, Cahliková L, Locarek M, Ali BH, Manoj P, Ramkumar A, Al Suleimani YM, Al Za'abi M, Karaca T, Nemmar A.

Nat Prod Commun. 2017 Jan;12(1):43-45.

PMID:
30549821
11.

The Biological Activity of Alkaloids from the Amaryllidaceae: From Cholinesterases Inhibition to Anticancer Activity.

Habartová K, Cahlíková L, Řezáčová M, Havelek R.

Nat Prod Commun. 2016 Oct;11(10):1587-1594.

PMID:
30549626
12.

Cytotoxicity of Naturally Occurring Isoquinoline Alkaloids of Different Structural Types.

Chlebek J, Doskocil I, Hulcová D, Breiterová K, Šafratová M, Havelek R, Habartová K, Hošt'álková A, Volštátová T, Cahlíková L.

Nat Prod Commun. 2016 Jun;11(6):753-6.

PMID:
27534109
13.

Comparative cytotoxicity of chelidonine and homochelidonine, the dimethoxy analogues isolated from Chelidonium majus L. (Papaveraceae), against human leukemic and lung carcinoma cells.

Havelek R, Seifrtova M, Kralovec K, Krocova E, Tejkalova V, Novotny I, Cahlikova L, Safratova M, Opletal L, Bilkova Z, Vavrova J, Rezacova M.

Phytomedicine. 2016 Mar 15;23(3):253-66. doi: 10.1016/j.phymed.2016.01.001. Epub 2016 Jan 22.

PMID:
26969379
14.

Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets.

Chlebek J, De Simone A, Hošťálková A, Opletal L, Pérez C, Pérez DI, Havlíková L, Cahlíková L, Andrisano V.

Fitoterapia. 2016 Mar;109:241-7. doi: 10.1016/j.fitote.2016.01.008. Epub 2016 Jan 11.

15.

Isoquinoline Alkaloids from Fumaria officinalis L. and Their Biological Activities Related to Alzheimer's Disease.

Chlebek J, Novák Z, Kassemová D, Šafratová M, Kostelník J, Malý L, Ločárek M, Opletal L, Hošt'álková A, Hrabinová M, Kuneš J, Novotná P, Urbanová M, Nováková L, Macáková K, Hulcová D, Solich P, Pérez Martín C, Jun D, Cahlíková L.

Chem Biodivers. 2016 Jan;13(1):91-9. doi: 10.1002/cbdv.201500033.

PMID:
26765356
16.

(+)-Chenabinol (Revised NMR Data) and Two New Alkaloids from Berberis vulgaris and their Biological Activity.

Novák Z, Hošt'álková A, Opletal L, Nováková L, Hrabinová M, Kuneš J, Cahlíková L.

Nat Prod Commun. 2015 Oct;10(10):1695-7.

PMID:
26669104
17.

Antifungal and Antibacterial Activity of Extracts and Alkaloids of Selected Amaryllidaceae Species.

Ločárek M, Nováková J, Klouček P, Hošt'álkoviá A, Kokoška L, Lucie Gábrlová, Šafratová M, Opletal L, Cahliková L.

Nat Prod Commun. 2015 Sep;10(9):1537-40.

PMID:
26594752
18.

LC-MS/MS method for the determination of haemanthamine in rat plasma, bile and urine and its application to a pilot pharmacokinetic study.

Hroch M, Mičuda S, Havelek R, Cermanová J, Cahlíková L, Hošťálková A, Hulcová D, Řezáčová M.

Biomed Chromatogr. 2016 Jul;30(7):1083-1091. doi: 10.1002/bmc.3653. Epub 2015 Dec 13.

PMID:
26577707
19.

Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment.

Zemanova L, Hofman J, Novotna E, Musilek K, Lundova T, Havrankova J, Hostalkova A, Chlebek J, Cahlikova L, Wsol V.

J Nat Prod. 2015 Nov 25;78(11):2666-74. doi: 10.1021/acs.jnatprod.5b00616. Epub 2015 Nov 3.

PMID:
26529431
20.

In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier.

Cahlíková L, Pérez DI, Štěpánková Š, Chlebek J, Šafratová M, Hošt'álková A, Opletal L.

J Nat Prod. 2015 Jun 26;78(6):1189-92. doi: 10.1021/acs.jnatprod.5b00191. Epub 2015 Jun 1.

PMID:
26030662

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