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Items: 16


Targeting histone deacetylase and NFκB signaling as a novel therapy for Mucoepidermoid Carcinomas.

Wagner VP, Martins MD, Martins MAT, Almeida LO, Warner KA, Nör JE, Squarize CH, Castilho RM.

Sci Rep. 2018 Feb 1;8(1):2065. doi: 10.1038/s41598-018-20345-w.


Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy.

Castilho RM, Squarize CH, Almeida LO.

Int J Mol Sci. 2017 Jul 12;18(7). pii: E1506. doi: 10.3390/ijms18071506. Review.


PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells.

Zagni C, Almeida LO, Balan T, Martins MT, Rosselli-Murai LK, Papagerakis P, Castilho RM, Squarize CH.

Stem Cell Reports. 2017 Jul 11;9(1):304-314. doi: 10.1016/j.stemcr.2017.05.006. Epub 2017 Jun 8.


SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation.

Almeida LO, Neto MPC, Sousa LO, Tannous MA, Curti C, Leopoldino AM.

Oncotarget. 2017 Apr 18;8(16):26802-26818. doi: 10.18632/oncotarget.15818.


Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence.

Almeida LO, Guimarães DM, Martins MD, Martins MAT, Warner KA, Nör JE, Castilho RM, Squarize CH.

Stem Cell Res. 2017 May;21:94-105. doi: 10.1016/j.scr.2017.04.003. Epub 2017 Apr 8. No abstract available.


Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells.

Guimarães DM, Almeida LO, Martins MD, Warner KA, Silva AR, Vargas PA, Nunes FD, Squarize CH, Nör JE, Castilho RM.

Oncotarget. 2016 Jul 5;7(27):42447-42460. doi: 10.18632/oncotarget.9884.


PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells.

Matsumoto CS, Almeida LO, Guimarães DM, Martins MD, Papagerakis P, Papagerakis S, Leopoldino AM, Castilho RM, Squarize CH.

Oncotarget. 2016 Jul 5;7(27):42393-42407. doi: 10.18632/oncotarget.9877.


Profiling the Behavior of Distinct Populations of Head and Neck Cancer Stem Cells.

Almeida LO, Guimarães DM, Squarize CH, Castilho RM.

Cancers (Basel). 2016 Jan 4;8(1). pii: E7. doi: 10.3390/cancers8010007.


Epigenetic Modifications and Accumulation of DNA Double-Strand Breaks in Oral Lichen Planus Lesions Presenting Poor Response to Therapy.

Dillenburg CS, Martins MA, Almeida LO, Meurer L, Squarize CH, Martins MD, Castilho RM.

Medicine (Baltimore). 2015 Jul;94(30):e997. doi: 10.1097/MD.0000000000000997.


SET overexpression in HEK293 cells regulates mitochondrial uncoupling proteins levels within a mitochondrial fission/reduced autophagic flux scenario.

Almeida LO, Goto RN, Neto MP, Sousa LO, Curti C, Leopoldino AM.

Biochem Biophys Res Commun. 2015 Mar 6;458(2):300-6. doi: 10.1016/j.bbrc.2015.01.104. Epub 2015 Feb 3.


Accumulated SET protein up-regulates and interacts with hnRNPK, increasing its binding to nucleic acids, the Bcl-xS repression, and cellular proliferation.

Almeida LO, Garcia CB, Matos-Silva FA, Curti C, Leopoldino AM.

Biochem Biophys Res Commun. 2014 Feb 28;445(1):196-202. doi: 10.1016/j.bbrc.2014.01.175. Epub 2014 Feb 4.


NFκB mediates cisplatin resistance through histone modifications in head and neck squamous cell carcinoma (HNSCC).

Almeida LO, Abrahao AC, Rosselli-Murai LK, Giudice FS, Zagni C, Leopoldino AM, Squarize CH, Castilho RM.

FEBS Open Bio. 2013 Dec 30;4:96-104. doi: 10.1016/j.fob.2013.12.003. eCollection 2014.


Periostin responds to mechanical stress and tension by activating the MTOR signaling pathway.

Rosselli-Murai LK, Almeida LO, Zagni C, Galindo-Moreno P, Padial-Molina M, Volk SL, Murai MJ, Rios HF, Squarize CH, Castilho RM.

PLoS One. 2013 Dec 13;8(12):e83580. doi: 10.1371/journal.pone.0083580. eCollection 2013.


SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates.

Almeida LO, Goto RN, Pestana CR, Uyemura SA, Gutkind S, Curti C, Leopoldino AM.

FEBS J. 2012 Dec;279(24):4615-28. doi: 10.1111/febs.12047. Epub 2012 Nov 23.


SET protein accumulates in HNSCC and contributes to cell survival: antioxidant defense, Akt phosphorylation and AVOs acidification.

Leopoldino AM, Squarize CH, Garcia CB, Almeida LO, Pestana CR, Sobral LM, Uyemura SA, Tajara EH, Silvio Gutkind J, Curti C.

Oral Oncol. 2012 Nov;48(11):1106-13. doi: 10.1016/j.oraloncology.2012.05.014. Epub 2012 Jun 26.


Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling.

Leopoldino AM, Squarize CH, Garcia CB, Almeida LO, Pestana CR, Polizello AC, Uyemura SA, Tajara EH, Gutkind JS, Curti C.

Mol Cell Biochem. 2012 Apr;363(1-2):65-74. doi: 10.1007/s11010-011-1158-x. Epub 2011 Dec 6.


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