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Materials (Basel). 2018 Mar 8;11(3). pii: E400. doi: 10.3390/ma11030400.

Electrospun F18 Bioactive Glass/PCL-Poly (ε-caprolactone)-Membrane for Guided Tissue Regeneration.

Author information

1
CeRTEV-Center for Research, Technology and Education in Vitreous Materials, Department of Materials Engineering, Federal University of São Carlos, 13565-905 São Carlos, Brazil. lucaspitaluga@gmail.com.
2
CeRTEV-Center for Research, Technology and Education in Vitreous Materials, Department of Materials Engineering, Federal University of São Carlos, 13565-905 São Carlos, Brazil. marina.trevelin@gmail.com.
3
CeRTEV-Center for Research, Technology and Education in Vitreous Materials, Department of Materials Engineering, Federal University of São Carlos, 13565-905 São Carlos, Brazil. dedz@ufscar.br.
4
School of Clinical Dentistry, The University of Sheffield, 19 Claremont Crescent, Sheffield S10 2TA, UK. santocildes@yahoo.com.
5
School of Clinical Dentistry, The University of Sheffield, 19 Claremont Crescent, Sheffield S10 2TA, UK. paul.hatton@sheffield.ac.uk.

Abstract

Barrier membranes that are used for guided tissue regeneration (GTR) therapy usually lack bioactivity and the capability to promote new bone tissue formation. However, the incorporation of an osteogenic agent into polymeric membranes seems to be the most assertive strategy to enhance their regenerative potential. Here, the manufacturing of composite electrospun membranes made of poly (ε-caprolactone) (PCL) and particles of a novel bioactive glass composition (F18) is described. The membranes were mechanically and biologically tested with tensile strength tests and tissue culture with MG-63 osteoblast-like cell line, respectively. The PCL-F18 composite membranes demonstrated no increased cytotoxicity and an enhanced osteogenic potential when compared to pure PCL membranes. Moreover, the addition of the bioactive phase increased the membrane tensile strength. These preliminary results suggested that these new membranes can be a strong candidate for small bone injuries treatment by GTR technique.

KEYWORDS:

bioactive glass; bone regeneration; electrospinning; guided tissue regeneration; membranes; tissue engineering

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