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N-Acetyl cysteine ameliorates hyperglycemia-induced cardiomyocyte toxicity by improving mitochondrial energetics and enhancing endogenous Coenzyme Q9/10 levels.

Dludla PV, Orlando P, Silvestri S, Mazibuko-Mbeje SE, Johnson R, Marcheggiani F, Cirilli I, Muller CJF, Louw J, Obonye N, Nyawo T, Nkambule BB, Tiano L.

Toxicol Rep. 2019 Nov 5;6:1240-1245. doi: 10.1016/j.toxrep.2019.11.004. eCollection 2019.


A systematic review on the functional role of Th1/Th2 cytokines in type 2 diabetes and related metabolic complications.

Mahlangu T, Dludla PV, Nyambuya TM, Mxinwa V, Mazibuko-Mbeje SE, Cirilli I, Marcheggiani F, Tiano L, Louw J, Nkambule BB.

Cytokine. 2019 Nov 5;126:154892. doi: 10.1016/j.cyto.2019.154892. [Epub ahead of print] Review.


Impact of Cold versus Hot Brewing on the Phenolic Profile and Antioxidant Capacity of Rooibos (Aspalathus linearis) Herbal Tea.

Damiani E, Carloni P, Rocchetti G, Senizza B, Tiano L, Joubert E, de Beer D, Lucini L.

Antioxidants (Basel). 2019 Oct 21;8(10). pii: E499. doi: 10.3390/antiox8100499.


Evaluation of gene expression of different molecular biomarkers of stress response as an effect of copper exposure on the earthworm EIsenia Andrei.

Mincarelli L, Tiano L, Craft J, Marcheggiani F, Vischetti C.

Ecotoxicology. 2019 Oct;28(8):938-948. doi: 10.1007/s10646-019-02093-3. Epub 2019 Aug 11.


Three Months Monitored Metabolic Fitness Modulates Cardiovascular Risk Factors in Diabetic Patients.

Cirilli I, Silvestri S, Marcheggiani F, Olivieri F, Galeazzi R, Antonicelli R, Recchioni R, Marcheselli F, Bacchetti T, Tiano L, Orlando P.

Diabetes Metab J. 2019 Jun 27. doi: 10.4093/dmj.2018.0254. [Epub ahead of print]


HDL functionality in follicular fluid in normal-weight and obese women undergoing assisted reproductive treatment.

Bacchetti T, Morresi C, Vignini A, Tiano L, Orlando P, Montik N, Ciavattini A, Ferretti G.

J Assist Reprod Genet. 2019 Aug;36(8):1657-1664. doi: 10.1007/s10815-019-01523-9. Epub 2019 Jul 23.


The beneficial effects of N-acetyl cysteine (NAC) against obesity associated complications: A systematic review of pre-clinical studies.

Dludla PV, Mazibuko-Mbeje SE, Nyambuya TM, Mxinwa V, Tiano L, Marcheggiani F, Cirilli I, Louw J, Nkambule BB.

Pharmacol Res. 2019 Aug;146:104332. doi: 10.1016/j.phrs.2019.104332. Epub 2019 Jun 26. Review.


Modulation of Coenzyme Q10 content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging.

Marcheggiani F, Cirilli I, Orlando P, Silvestri S, Vogelsang A, Knott A, Blatt T, Weise JM, Tiano L.

Aging (Albany NY). 2019 May 10;11(9):2565-2582. doi: 10.18632/aging.101926.


Aspalathin-Rich Green Rooibos Extract Lowers LDL-Cholesterol and Oxidative Status in High-Fat Diet-Induced Diabetic Vervet Monkeys.

Orlando P, Chellan N, Louw J, Tiano L, Cirilli I, Dludla P, Joubert E, Muller CJF.

Molecules. 2019 May 2;24(9). pii: E1713. doi: 10.3390/molecules24091713.


Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration.

Mazibuko-Mbeje SE, Dludla PV, Johnson R, Joubert E, Louw J, Ziqubu K, Tiano L, Silvestri S, Orlando P, Opoku AR, Muller CJF.

PLoS One. 2019 May 2;14(5):e0216172. doi: 10.1371/journal.pone.0216172. eCollection 2019.


Menaquinone 7 Stability of Formulations and Its Relationship with Purity Profile.

Orlando P, Silvestri S, Marcheggiani F, Cirilli I, Tiano L.

Molecules. 2019 Feb 26;24(5). pii: E829. doi: 10.3390/molecules24050829.


Inflammation and Oxidative Stress in an Obese State and the Protective Effects of Gallic Acid.

Dludla PV, Nkambule BB, Jack B, Mkandla Z, Mutize T, Silvestri S, Orlando P, Tiano L, Louw J, Mazibuko-Mbeje SE.

Nutrients. 2018 Dec 21;11(1). pii: E23. doi: 10.3390/nu11010023. Review.


Modulation of Oxidative Status by Normoxia and Hypoxia on Cultures of Human Dermal Fibroblasts: How Does It Affect Cell Aging?

Damiani E, Brugè F, Cirilli I, Marcheggiani F, Olivieri F, Armeni T, Cianfruglia L, Giuliani A, Orlando P, Tiano L.

Oxid Med Cell Longev. 2018 Sep 23;2018:5469159. doi: 10.1155/2018/5469159. eCollection 2018.


The mitomiR/Bcl-2 axis affects mitochondrial function and autophagic vacuole formation in senescent endothelial cells.

Giuliani A, Cirilli I, Prattichizzo F, MensĂ  E, Fulgenzi G, Sabbatinelli J, Graciotti L, Olivieri F, Procopio AD, Tiano L, Rippo MR.

Aging (Albany NY). 2018 Oct 21;10(10):2855-2873. doi: 10.18632/aging.101591.


CoQ10 Supplementation in Patients Undergoing IVF-ET: The Relationship with Follicular Fluid Content and Oocyte Maturity.

Giannubilo SR, Orlando P, Silvestri S, Cirilli I, Marcheggiani F, Ciavattini A, Tiano L.

Antioxidants (Basel). 2018 Oct 13;7(10). pii: E141. doi: 10.3390/antiox7100141.


Uncoupling proteins as a therapeutic target to protect the diabetic heart.

Dludla PV, Nkambule BB, Tiano L, Louw J, Jastroch M, Mazibuko-Mbeje SE.

Pharmacol Res. 2018 Nov;137:11-24. doi: 10.1016/j.phrs.2018.09.013. Epub 2018 Sep 14.


Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes.

Orlando P, Silvestri S, Galeazzi R, Antonicelli R, Marcheggiani F, Cirilli I, Bacchetti T, Tiano L.

Redox Rep. 2018 Dec;23(1):136-145. doi: 10.1080/13510002.2018.1472924.


The effect of long-term treatment with coenzyme Q10 on nucleic acid modifications by oxidation in children with Down syndrome.

Larsen EL, Padella L, Bergholdt HKM, Henriksen T, Santoro L, Gabrielli O, Poulsen HE, Littarru GP, Orlando P, Tiano L.

Neurobiol Aging. 2018 Jul;67:159-161. doi: 10.1016/j.neurobiolaging.2018.03.001. Epub 2018 Mar 15.


Coenzyme Q10 as a therapeutic candidate for treating inherited photoreceptor degeneration.

Zhang X, Biswas L, Tohari AM, Reilly J, Tiano L, Shu X.

Neural Regen Res. 2017 Dec;12(12):1979-1981. doi: 10.4103/1673-5374.221152. No abstract available.


Oxidative stress in adult growth hormone deficiency: different plasma antioxidant patterns in comparison with metabolic syndrome.

Mancini A, Di Segni C, Bruno C, Olivieri G, Guidi F, Silvestrini A, Meucci E, Orlando P, Silvestri S, Tiano L, Pontecorvi A.

Endocrine. 2018 Jan;59(1):130-136. doi: 10.1007/s12020-017-1468-1. Epub 2017 Nov 15.


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