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Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer's disease.

Brunetti L, Laghezza A, Loiodice F, Tortorella P, Piemontese L.

Neural Regen Res. 2020 Jan;15(1):67-68. doi: 10.4103/1673-5374.264458. No abstract available.


New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation.

Brunetti L, Loiodice F, Piemontese L, Tortorella P, Laghezza A.

J Med Chem. 2019 Aug 22. doi: 10.1021/acs.jmedchem.9b00885. [Epub ahead of print]


An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands.

Laghezza A, Piemontese L, Tortorella P, Loiodice F.

Eur J Med Chem. 2019 Aug 15;176:326-342. doi: 10.1016/j.ejmech.2019.05.012. Epub 2019 May 11. Review.


Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists.

Sabatino L, Ziccardi P, Cerchia C, Muccillo L, Piemontese L, Loiodice F, Colantuoni V, Lupo A, Lavecchia A.

Sci Rep. 2019 Apr 1;9(1):5434. doi: 10.1038/s41598-019-41765-2.


Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation.

Laghezza A, Piemontese L, Cerchia C, Montanari R, Capelli D, Giudici M, Crestani M, Tortorella P, Peiretti F, Pochetti G, Lavecchia A, Loiodice F.

J Med Chem. 2018 Sep 27;61(18):8282-8298. doi: 10.1021/acs.jmedchem.8b00835. Epub 2018 Sep 18.


Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates.

Piemontese L, Tomás D, Hiremathad A, Capriati V, Candeias E, Cardoso SM, Chaves S, Santos MA.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1212-1224. doi: 10.1080/14756366.2018.1491564.


Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer's Disease.

Piemontese L, Vitucci G, Catto M, Laghezza A, Perna FM, Rullo M, Loiodice F, Capriati V, Solfrizzo M.

Molecules. 2018 Aug 29;23(9). pii: E2182. doi: 10.3390/molecules23092182.


Effect of gaseous ozone treatments on DON, microbial contaminants and technological parameters of wheat and semolina.

Piemontese L, Messia MC, Marconi E, Falasca L, Zivoli R, Gambacorta L, Perrone G, Solfrizzo M.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Apr;35(4):760-771. doi: 10.1080/19440049.2017.1419285. Epub 2018 Jan 19.


Heterocyclic compounds as key structures for the interaction with old and new targets in Alzheimer's disease therapy.

Hiremathad A, Piemontese L.

Neural Regen Res. 2017 Aug;12(8):1256-1261. doi: 10.4103/1673-5374.213541. Review.


New approaches for prevention and treatment of Alzheimer's disease: a fascinating challenge.

Piemontese L.

Neural Regen Res. 2017 Mar;12(3):405-406. doi: 10.4103/1673-5374.202942. No abstract available.


Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update.

Chaves S, Piemontese L, Hiremathad A, Santos MA.

Curr Med Chem. 2018;25(1):97-112. doi: 10.2174/0929867324666170330092304. Review.


Deep Eutectic Solvents as Novel and Effective Extraction Media for Quantitative Determination of Ochratoxin A in Wheat and Derived Products.

Piemontese L, Perna FM, Logrieco A, Capriati V, Solfrizzo M.

Molecules. 2017 Jan 12;22(1). pii: E121. doi: 10.3390/molecules22010121.


New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity.

Piemontese L, Cerchia C, Laghezza A, Ziccardi P, Sblano S, Tortorella P, Iacobazzi V, Infantino V, Convertini P, Dal Piaz F, Lupo A, Colantuoni V, Lavecchia A, Loiodice F.

Eur J Med Chem. 2017 Feb 15;127:379-397. doi: 10.1016/j.ejmech.2016.12.047. Epub 2016 Dec 24.


Plant Food Supplements with Antioxidant Properties for the Treatment of Chronic and Neurodegenerative Diseases: Benefits or Risks?

Piemontese L.

J Diet Suppl. 2017 Jul 4;14(4):478-484. doi: 10.1080/19390211.2016.1247936. Epub 2016 Nov 28. Review.


Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity.

Tauro M, Laghezza A, Loiodice F, Piemontese L, Caradonna A, Capelli D, Montanari R, Pochetti G, Di Pizio A, Agamennone M, Campestre C, Tortorella P.

J Enzyme Inhib Med Chem. 2016;31(sup4):25-37. Epub 2016 Aug 24.


Reduction of Aflatoxins in Apricot Kernels by Electronic and Manual Color Sorting.

Zivoli R, Gambacorta L, Piemontese L, Solfrizzo M.

Toxins (Basel). 2016 Jan 19;8(1). pii: E26. doi: 10.3390/toxins8010026.


Food coloring agents and plant food supplements derived from Vitis vinifera: a new source of human exposure to ochratoxin A.

Solfrizzo M, Piemontese L, Gambacorta L, Zivoli R, Longobardi F.

J Agric Food Chem. 2015 Apr 8;63(13):3609-14. doi: 10.1021/acs.jafc.5b00326. Epub 2015 Mar 26.


On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles.

Laghezza A, Montanari R, Lavecchia A, Piemontese L, Pochetti G, Iacobazzi V, Infantino V, Capelli D, De Bellis M, Liantonio A, Pierno S, Tortorella P, Conte Camerino D, Loiodice F.

ChemMedChem. 2015 Mar;10(3):555-65. doi: 10.1002/cmdc.201402462. Epub 2015 Jan 29.


Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175.

Piemontese L, Fracchiolla G, Carrieri A, Parente M, Laghezza A, Carbonara G, Sblano S, Tauro M, Gilardi F, Tortorella P, Lavecchia A, Crestani M, Desvergne B, Loiodice F.

Eur J Med Chem. 2015 Jan 27;90:583-94. doi: 10.1016/j.ejmech.2014.11.044. Epub 2014 Nov 24.


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