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Items: 1 to 20 of 190

1.

Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).

de Heuvel E, Singh AK, Boronat P, Kooistra AJ, van der Meer T, Sadek P, Blaazer AR, Shaner NC, Bindels DS, Caljon G, Maes L, Sterk GJ, Siderius M, Oberholzer M, de Esch IJP, Brown DG, Leurs R.

Bioorg Med Chem. 2019 Jul 5. pii: S0968-0896(19)30790-4. doi: 10.1016/j.bmc.2019.06.026. [Epub ahead of print]

2.

The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis.

Cappoen D, Torfs E, Meiresonne T, Claes P, Semina E, Holvoet F, de Macedo MB, Cools F, Piller T, Matheeussen A, Van Calster K, Caljon G, Delputte P, Maes L, Neyrolles O, De Kimpe N, Mangelinckx S, Cos P.

Eur J Med Chem. 2019 Jul 19;181:111549. doi: 10.1016/j.ejmech.2019.07.052. [Epub ahead of print]

PMID:
31376569
3.

Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors.

de Heuvel E, Singh AK, Edink E, van der Meer T, van der Woude M, Sadek P, Krell-Jørgensen MP, van den Bergh T, Veerman J, Caljon G, Kalejaiye TD, Wijtmans M, Maes L, de Koning HP, Jan Sterk G, Siderius M, de Esch IJP, Brown DG, Leurs R.

Bioorg Med Chem. 2019 Jun 18. pii: S0968-0896(18)31629-8. doi: 10.1016/j.bmc.2019.06.027. [Epub ahead of print]

4.

Identification of Phenylpyrazolone Dimers as a New Class of Anti-Trypanosoma cruzi Agents.

Sijm M, Siciliano de Araújo J, Llorca AR, Orrling K, Stiny L, Matheeussen A, Maes L, de Esch IJP, Soeiro MNC, Sterk GJ, Leurs R.

ChemMedChem. 2019 Jul 18. doi: 10.1002/cmdc.201900370. [Epub ahead of print]

PMID:
31319019
5.

Characterization of the role of N-glycosylation sites in the respiratory syncytial virus fusion protein in virus replication, syncytium formation and antigenicity.

Leemans A, Boeren M, Van der Gucht W, Martinet W, Caljon G, Maes L, Cos P, Delputte P.

Virus Res. 2019 Jun;266:58-68. doi: 10.1016/j.virusres.2019.04.006. Epub 2019 Apr 17.

PMID:
31004621
6.

Double prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents.

Courtens C, Risseeuw M, Caljon G, Maes L, Cos P, Martin A, Van Calenbergh S.

Bioorg Med Chem Lett. 2019 May 15;29(10):1232-1235. doi: 10.1016/j.bmcl.2019.03.009. Epub 2019 Mar 7.

PMID:
30879839
7.

Optimization and Characterization of a Galleria mellonella Larval Infection Model for Virulence Studies and the Evaluation of Therapeutics Against Streptococcus pneumoniae.

Cools F, Torfs E, Aizawa J, Vanhoutte B, Maes L, Caljon G, Delputte P, Cappoen D, Cos P.

Front Microbiol. 2019 Feb 21;10:311. doi: 10.3389/fmicb.2019.00311. eCollection 2019.

8.

In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.

Cimanga RK, Nsaka SL, Tshodi ME, Mbamu BM, Kikweta CM, Makila FB, Cos P, Maes L, Vlietinck AJ, Exarchou V, Tuenter E, Pieters L.

J Ethnopharmacol. 2019 Oct 5;242:111736. doi: 10.1016/j.jep.2019.02.019. Epub 2019 Feb 11.

PMID:
30763695
9.

Amino acid based prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents.

Courtens C, Risseeuw M, Caljon G, Maes L, Martin A, Van Calenbergh S.

Bioorg Med Chem. 2019 Mar 1;27(5):729-747. doi: 10.1016/j.bmc.2019.01.016. Epub 2019 Jan 17.

PMID:
30692024
10.

Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity.

Hulpia F, Campagnaro GD, Scortichini M, Van Hecke K, Maes L, de Koning HP, Caljon G, Van Calenbergh S.

Eur J Med Chem. 2019 Feb 15;164:689-705. doi: 10.1016/j.ejmech.2018.12.050. Epub 2018 Dec 21.

PMID:
30677668
11.

Imidazole Derivatives as Promising Agents for the Treatment of Chagas Disease.

de Araújo JS, García-Rubia A, Sebastián-Pérez V, Kalejaiye TD, Bernardino da Silva P, Fonseca-Berzal CR, Maes L, De Koning HP, Soeiro MNC, Gil C.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02156-18. doi: 10.1128/AAC.02156-18. Print 2019 Apr.

PMID:
30670432
12.

Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity.

Botros SS, William S, Sabra AA, El-Lakkany NM, Seif El-Din SH, García-Rubia A, Sebastián-Pérez V, Blaazer AR, de Heuvel E, Sijm M, Zheng Y, Salado IG, Munday JC, Maes L, de Esch IJP, Sterk GJ, Augustyns K, Leurs R, Gil C, De Koning HP.

Int J Parasitol Drugs Drug Resist. 2019 Apr;9:35-43. doi: 10.1016/j.ijpddr.2019.01.001. Epub 2019 Jan 14.

13.

Synthesis and antimicrobial activities of N6-hydroxyagelasine analogs and revision of the structure of ageloximes.

Paulsen B, Fredriksen KA, Petersen D, Maes L, Matheeussen A, Naemi AO, Scheie AA, Simm R, Ma R, Wan B, Franzblau S, Gundersen LL.

Bioorg Med Chem. 2019 Feb 15;27(4):620-629. doi: 10.1016/j.bmc.2019.01.002. Epub 2019 Jan 4.

PMID:
30638761
14.

HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima.

Zarev Y, Foubert K, Cos P, Maes L, Elgorashi E, Apers S, Ionkova I, Pieters L.

Nat Prod Res. 2019 Jan 3:1-4. doi: 10.1080/14786419.2018.1539976. [Epub ahead of print]

PMID:
30602319
15.

Miltefosine enhances the fitness of a non-virulent drug-resistant Leishmania infantum strain.

Eberhardt E, Bulté D, Van Bockstal L, Van den Kerkhof M, Cos P, Delputte P, Hendrickx S, Maes L, Caljon G.

J Antimicrob Chemother. 2019 Feb 1;74(2):395-406. doi: 10.1093/jac/dky450.

PMID:
30412253
16.

Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy.

Devisscher L, Van Coillie S, Hofmans S, Van Rompaey D, Goossens K, Meul E, Maes L, De Winter H, Van Der Veken P, Vandenabeele P, Berghe TV, Augustyns K.

J Med Chem. 2018 Nov 21;61(22):10126-10140. doi: 10.1021/acs.jmedchem.8b01299. Epub 2018 Nov 6.

PMID:
30354101
17.

Discovery of Novel 7-Aryl 7-Deazapurine 3'-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi.

Hulpia F, Van Hecke K, França da Silva C, da Gama Jaen Batista D, Maes L, Caljon G, de Nazaré C Soeiro M, Van Calenbergh S.

J Med Chem. 2018 Oct 25;61(20):9287-9300. doi: 10.1021/acs.jmedchem.8b00999. Epub 2018 Oct 3.

PMID:
30234983
18.

Removal of the N-Glycosylation Sequon at Position N116 Located in p27 of the Respiratory Syncytial Virus Fusion Protein Elicits Enhanced Antibody Responses after DNA Immunization.

Leemans A, Boeren M, Van der Gucht W, Pintelon I, Roose K, Schepens B, Saelens X, Bailey D, Martinet W, Caljon G, Maes L, Cos P, Delputte P.

Viruses. 2018 Aug 14;10(8). pii: E426. doi: 10.3390/v10080426.

19.

Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy.

Sebastián-Pérez V, Hendrickx S, Munday JC, Kalejaiye T, Martínez A, Campillo NE, de Koning H, Caljon G, Maes L, Gil C.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00603-18. doi: 10.1128/AAC.00603-18. Print 2018 Oct.

20.

The impact of the age of first blood meal and Zika virus infection on Aedes aegypti egg production and longevity.

Petersen MT, Silveira IDD, Tátila-Ferreira A, David MR, Chouin-Carneiro T, Van den Wouwer L, Maes L, Maciel-de-Freitas R.

PLoS One. 2018 Jul 26;13(7):e0200766. doi: 10.1371/journal.pone.0200766. eCollection 2018.

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