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Items: 1 to 20 of 42

1.

Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development.

Nabinger SC, Chen S, Gao R, Yao C, Kobayashi M, Vemula S, Fahey AC, Wang C, Daniels C, Boswell HS, Sandusky GE, Mayo LD, Kapur R, Liu Y.

Leukemia. 2019 Jun;33(6):1535-1539. doi: 10.1038/s41375-019-0377-0. Epub 2019 Jan 23. No abstract available.

PMID:
30675010
2.

Protein phosphatase 5 and the tumor suppressor p53 down-regulate each other's activities in mice.

Wang J, Shen T, Zhu W, Dou L, Gu H, Zhang L, Yang Z, Chen H, Zhou Q, Sánchez ER, Field LJ, Mayo LD, Xie Z, Xiao D, Lin X, Shou W, Yong W.

J Biol Chem. 2018 Nov 23;293(47):18218-18229. doi: 10.1074/jbc.RA118.004256. Epub 2018 Sep 27.

PMID:
30262665
3.

The proto-oncogene function of Mdm2 in bone.

Olivos DJ 3rd, Perrien DS, Hooker A, Cheng YH, Fuchs RK, Hong JM, Bruzzaniti A, Chun K, Eischen CM, Kacena MA, Mayo LD.

J Cell Biochem. 2018 Nov;119(11):8830-8840. doi: 10.1002/jcb.27133. Epub 2018 Jul 16.

4.

Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis.

Sisti F, Wang S, Brandt SL, Glosson-Byers N, Mayo LD, Son YM, Sturgeon S, Filgueiras L, Jancar S, Wong H, Dela Cruz CS, Andrews N, Alves-Filho JC, Cunha FQ, Serezani CH.

Sci Signal. 2018 May 1;11(528). pii: eaai9085. doi: 10.1126/scisignal.aai9085.

PMID:
29717063
5.

Mutant and wild-type p53 form complexes with p73 upon phosphorylation by the kinase JNK.

Wolf ER, McAtarsney CP, Bredhold KE, Kline AM, Mayo LD.

Sci Signal. 2018 Apr 3;11(524). pii: eaao4170. doi: 10.1126/scisignal.aao4170.

PMID:
29615516
6.

The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2).

Hauck PM, Wolf ER, Olivos DJ 3rd, McAtarsney CP, Mayo LD.

Oncotarget. 2017 Nov 6;8(61):104455-104466. doi: 10.18632/oncotarget.22320. eCollection 2017 Nov 28.

7.

Early-Stage Metastasis Requires Mdm2 and Not p53 Gain of Function.

Hauck PM, Wolf ER, Olivos DJ 3rd, Batuello CN, McElyea KC, McAtarsney CP, Cournoyer RM, Sandusky GE, Mayo LD.

Mol Cancer Res. 2017 Nov;15(11):1598-1607. doi: 10.1158/1541-7786.MCR-17-0174. Epub 2017 Aug 7.

8.

Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness.

Olivos DJ, Mayo LD.

Int J Mol Sci. 2016 Nov 26;17(12). pii: E1982. Review.

9.

Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist.

Wang H, Cai S, Bailey BJ, Reza Saadatzadeh M, Ding J, Tonsing-Carter E, Georgiadis TM, Zachary Gunter T, Long EC, Minto RE, Gordon KR, Sen SE, Cai W, Eitel JA, Waning DL, Bringman LR, Wells CD, Murray ME, Sarkaria JN, Gelbert LM, Jones DR, Cohen-Gadol AA, Mayo LD, Shannon HE, Pollok KE.

J Neurosurg. 2017 Feb;126(2):446-459. doi: 10.3171/2016.1.JNS152513. Epub 2016 May 13.

10.

Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model.

Tonsing-Carter E, Bailey BJ, Saadatzadeh MR, Ding J, Wang H, Sinn AL, Peterman KM, Spragins TK, Silver JM, Sprouse AA, Georgiadis TM, Gunter TZ, Long EC, Minto RE, Marchal CC, Batuello CN, Safa AR, Hanenberg H, Territo PR, Sandusky GE, Mayo LD, Eischen CM, Shannon HE, Pollok KE.

Mol Cancer Ther. 2015 Dec;14(12):2850-63. doi: 10.1158/1535-7163.MCT-15-0237. Epub 2015 Oct 22.

11.

Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase.

Batuello CN, Hauck PM, Gendron JM, Lehman JA, Mayo LD.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1749-54. doi: 10.1073/pnas.1416656112. Epub 2015 Jan 26.

12.

Ferroxitosis: a cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma.

Lakhter AJ, Hamilton J, Dagher PC, Mukkamala S, Hato T, Dong XC, Mayo LD, Harris RA, Shekhar A, Ivan M, Brustovetsky N, Naidu SR.

Oncotarget. 2014 Dec 30;5(24):12694-703.

13.

Signaling pathways involved in megakaryocyte-mediated proliferation of osteoblast lineage cells.

Cheng YH, Streicher DA, Waning DL, Chitteti BR, Gerard-O'Riley R, Horowitz MC, Bidwell JP, Pavalko FM, Srour EF, Mayo LD, Kacena MA.

J Cell Physiol. 2015 Mar;230(3):578-86. doi: 10.1002/jcp.24774.

14.

Serdemetan antagonizes the Mdm2-HIF1α axis leading to decreased levels of glycolytic enzymes.

Lehman JA, Hauck PM, Gendron JM, Batuello CN, Eitel JA, Albig A, Kadakia MP, Mayo LD.

PLoS One. 2013 Sep 6;8(9):e74741. doi: 10.1371/journal.pone.0074741. eCollection 2013.

15.

Temozolomide-mediated DNA methylation in human myeloid precursor cells: differential involvement of intrinsic and extrinsic apoptotic pathways.

Wang H, Cai S, Ernstberger A, Bailey BJ, Wang MZ, Cai W, Goebel WS, Czader MB, Crean C, Suvannasankha A, Shokolenkoc I, Wilson GL, Baluyut AR, Mayo LD, Pollok KE.

Clin Cancer Res. 2013 May 15;19(10):2699-709. doi: 10.1158/1078-0432.CCR-12-2671. Epub 2013 Mar 27.

16.

Pyk2 regulates megakaryocyte-induced increases in osteoblast number and bone formation.

Cheng YH, Hooker RA, Nguyen K, Gerard-O'Riley R, Waning DL, Chitteti BR, Meijome TE, Chua HL, Plett AP, Orschell CM, Srour EF, Mayo LD, Pavalko FM, Bruzzaniti A, Kacena MA.

J Bone Miner Res. 2013 Jun;28(6):1434-45. doi: 10.1002/jbmr.1876.

17.

Integration of DNA damage and repair with murine double-minute 2 (Mdm2) in tumorigenesis.

Lehman JA, Mayo LD.

Int J Mol Sci. 2012 Dec 3;13(12):16373-86. doi: 10.3390/ijms131216373. Review.

18.

Directing p53 to induce autophagy.

Mayo LD.

Cell Cycle. 2012 Sep 15;11(18):3353-4. doi: 10.4161/cc.21849. Epub 2012 Aug 23.

19.

Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth.

Zhang Y, Zhang Q, Zeng SX, Zhang Y, Mayo LD, Lu H.

Cancer Biol Ther. 2012 Aug;13(10):915-24. doi: 10.4161/cbt.20844. Epub 2012 Aug 1.

20.

Megakaryocytes regulate expression of Pyk2 isoforms and caspase-mediated cleavage of actin in osteoblasts.

Kacena MA, Eleniste PP, Cheng YH, Huang S, Shivanna M, Meijome TE, Mayo LD, Bruzzaniti A.

J Biol Chem. 2012 May 18;287(21):17257-68. doi: 10.1074/jbc.M111.309880. Epub 2012 Mar 23.

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