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Items: 1 to 20 of 33

1.

Structural Determinants of the Prion Protein N-Terminus and Its Adducts with Copper Ions.

Sánchez-López C, Rossetti G, Quintanar L, Carloni P.

Int J Mol Sci. 2018 Dec 20;20(1). pii: E18. doi: 10.3390/ijms20010018. Review.

2.

Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features.

Gentile I, Garro HA, Delgado Ocaña S, Gonzalez N, Strohäker T, Schibich D, Quintanar L, Sambrotta L, Zweckstetter M, Griesinger C, Menacho Márquez M, Fernández CO.

Metallomics. 2018 Oct 17;10(10):1383-1389. doi: 10.1039/c8mt00232k.

PMID:
30246210
3.

A Histidine Switch for Zn-Induced Aggregation of γ-Crystallins Reveals a Metal-Bridging Mechanism That Is Relevant to Cataract Disease.

Domínguez-Calva JA, Haase-Pettingell C, Serebryany E, King JA, Quintanar L.

Biochemistry. 2018 Aug 21;57(33):4959-4962. doi: 10.1021/acs.biochem.8b00436. Epub 2018 Aug 7.

PMID:
30064223
4.

Neuroprotective alpha-cleavage of the human prion protein significantly impacts Cu(ii) coordination at its His111 site.

Sánchez-López C, Fernández CO, Quintanar L.

Dalton Trans. 2018 Jul 17;47(28):9274-9282. doi: 10.1039/c7dt03400h.

PMID:
29417110
5.

Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress.

Garza-Lombó C, Posadas Y, Quintanar L, Gonsebatt ME, Franco R.

Antioxid Redox Signal. 2018 Jun 20;28(18):1669-1703. doi: 10.1089/ars.2017.7272. Epub 2018 Mar 28.

PMID:
29402131
6.

Development of a Parenteral Formulation of NTS-Polyplex Nanoparticles for Clinical Purpose.

Aranda-Barradas ME, Márquez M, Quintanar L, Santoyo-Salazar J, Espadas-Álvarez AJ, Martínez-Fong D, García-García E.

Pharmaceutics. 2018 Jan 3;10(1). pii: E5. doi: 10.3390/pharmaceutics10010005.

7.

Bioinorganic Chemistry of Parkinson's Disease: Affinity and Structural Features of Cu(I) Binding to the Full-Length β-Synuclein Protein.

Miotto MC, Pavese MD, Quintanar L, Zweckstetter M, Griesinger C, Fernández CO.

Inorg Chem. 2017 Sep 5;56(17):10387-10395. doi: 10.1021/acs.inorgchem.7b01292. Epub 2017 Aug 18.

PMID:
28820253
8.

Effect of ionic strength on the aggregation kinetics of the amidated amyloid beta peptide Aβ (1-40) in aqueous solutions.

Campos-Ramírez A, Márquez M, Quintanar L, Rojas-Ochoa LF.

Biophys Chem. 2017 Sep;228:98-107. doi: 10.1016/j.bpc.2017.05.004. Epub 2017 May 19.

PMID:
28587777
9.

Copper Coordination Features of Human Islet Amyloid Polypeptide: The Type 2 Diabetes Peptide.

Sánchez-López C, Cortés-Mejía R, Miotto MC, Binolfi A, Fernández CO, Del Campo JM, Quintanar L.

Inorg Chem. 2016 Oct 5. [Epub ahead of print]

PMID:
27704849
10.

Role of N-terminal methionine residues in the redox activity of copper bound to alpha-synuclein.

Rodríguez EE, Arcos-López T, Trujano-Ortiz LG, Fernández CO, González FJ, Vela A, Quintanar L.

J Biol Inorg Chem. 2016 Sep;21(5-6):691-702. doi: 10.1007/s00775-016-1376-5. Epub 2016 Jul 15.

PMID:
27422629
11.

Spectroscopic and Theoretical Study of Cu(I) Binding to His111 in the Human Prion Protein Fragment 106-115.

Arcos-López T, Qayyum M, Rivillas-Acevedo L, Miotto MC, Grande-Aztatzi R, Fernández CO, Hedman B, Hodgson KO, Vela A, Solomon EI, Quintanar L.

Inorg Chem. 2016 Mar 21;55(6):2909-22. doi: 10.1021/acs.inorgchem.5b02794. Epub 2016 Mar 1.

12.

Copper and Zinc Ions Specifically Promote Nonamyloid Aggregation of the Highly Stable Human γ-D Crystallin.

Quintanar L, Domínguez-Calva JA, Serebryany E, Rivillas-Acevedo L, Haase-Pettingell C, Amero C, King JA.

ACS Chem Biol. 2016 Jan 15;11(1):263-72. doi: 10.1021/acschembio.5b00919. Epub 2015 Dec 3.

PMID:
26579725
13.

Structural basis for the inhibition of truncated islet amyloid polypeptide aggregation by Cu(II): insights into the bioinorganic chemistry of type II diabetes.

Rivillas-Acevedo L, Sánchez-López C, Amero C, Quintanar L.

Inorg Chem. 2015 Apr 20;54(8):3788-96. doi: 10.1021/ic502945k. Epub 2015 Mar 31.

PMID:
25826050
14.

Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells.

Chin-Chan M, Segovia J, Quintanar L, Arcos-López T, Hersh LB, Chow KM, Rodgers DW, Quintanilla-Vega B.

Toxicol Sci. 2015 May;145(1):128-37. doi: 10.1093/toxsci/kfv037. Epub 2015 Feb 10.

15.

Redox cycling of copper-amyloid β 1-16 peptide complexes is highly dependent on the coordination mode.

Trujano-Ortiz LG, González FJ, Quintanar L.

Inorg Chem. 2015 Jan 5;54(1):4-6. doi: 10.1021/ic501941a. Epub 2014 Dec 18.

PMID:
25521160
16.

A bifunctional non-natural tetrapeptide modulates amyloid-beta peptide aggregation in the presence of Cu(ii).

Márquez M, Blancas-Mejía LM, Campos A, Rojas L, Castañeda-Hernández G, Quintanar L.

Metallomics. 2014 Dec;6(12):2189-92. doi: 10.1039/c4mt00257a. Epub 2014 Oct 28.

PMID:
25350343
17.

Insights into the oxygen-based ligand of the low pH component of the Cu(2+)-amyloid-β complex.

Gomez-Castro CZ, Vela A, Quintanar L, Grande-Aztatzi R, Mineva T, Goursot A.

J Phys Chem B. 2014 Aug 28;118(34):10052-64. doi: 10.1021/jp5047529. Epub 2014 Aug 14.

PMID:
25090035
18.

Site-specific copper-catalyzed oxidation of α-synuclein: tightening the link between metal binding and protein oxidative damage in Parkinson's disease.

Miotto MC, Rodriguez EE, Valiente-Gabioud AA, Torres-Monserrat V, Binolfi A, Quintanar L, Zweckstetter M, Griesinger C, Fernández CO.

Inorg Chem. 2014 May 5;53(9):4350-8. doi: 10.1021/ic4031377. Epub 2014 Apr 11.

PMID:
24725094
19.

Biophysical and morphological studies on the dual interaction of non-octarepeat prion protein peptides with copper and nucleic acids.

Chaves JA, Sanchez-López C, Gomes MP, Sisnande T, Macedo B, de Oliveira VE, Braga CA, Rangel LP, Silva JL, Quintanar L, Cordeiro Y.

J Biol Inorg Chem. 2014 Aug;19(6):839-51. doi: 10.1007/s00775-014-1115-8. Epub 2014 Feb 21.

PMID:
24557708
20.

Insertion of beta-alanine in model peptides for copper binding to His96 and His111 of the human prion protein.

Rivillas-Acevedo L, Maciel-Barón L, García JE, Juaristi E, Quintanar L.

J Inorg Biochem. 2013 Sep;126:104-10. doi: 10.1016/j.jinorgbio.2013.05.016. Epub 2013 Jun 5.

PMID:
23796442

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