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Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation.

Owusu BY, Thomas S, Venukadasula P, Han Z, Janetka JW, Galemmo RA Jr, Klampfer L.

Oncotarget. 2017 May 29;8(38):63014-63025. doi: 10.18632/oncotarget.18260. eCollection 2017 Sep 8.


Hepatocyte Growth Factor, a Key Tumor-Promoting Factor in the Tumor Microenvironment.

Owusu BY, Galemmo R, Janetka J, Klampfer L.

Cancers (Basel). 2017 Apr 17;9(4). pii: E35. doi: 10.3390/cancers9040035. Review.


Modulation of STAT1-Driven Transcriptional Activity by Histone Deacetylases.

Owusu BY, Klampfer L.

Methods Mol Biol. 2017;1510:277-285.


Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling.

Owusu BY, Bansal N, Venukadasula PK, Ross LJ, Messick TE, Goel S, Galemmo RA, Klampfer L.

Oncotarget. 2016 May 17;7(20):29492-506. doi: 10.18632/oncotarget.8785.


Design and Synthesis of Nonpeptide Inhibitors of Hepatocyte Growth Factor Activation.

Venukadasula PK, Owusu BY, Bansal N, Ross LJ, Hobrath JV, Bao D, Truss JW, Stackhouse M, Messick TE, Klampfer L, Galemmo RA Jr.

ACS Med Chem Lett. 2015 Dec 22;7(2):177-81. doi: 10.1021/acsmedchemlett.5b00357. eCollection 2016 Feb 11.


α-Ketobenzothiazole Serine Protease Inhibitors of Aberrant HGF/c-MET and MSP/RON Kinase Pathway Signaling in Cancer.

Han Z, Harris PK, Karmakar P, Kim T, Owusu BY, Wildman SA, Klampfer L, Janetka JW.

ChemMedChem. 2016 Mar 17;11(6):585-99. doi: 10.1002/cmdc.201500600. Epub 2016 Feb 17.


Prognostic and Predictive Significance of Stromal Fibroblasts and Macrophages in Colon Cancer.

Owusu BY, Vaid M, Kaler P, Klampfer L.

Biomark Cancer. 2015 Nov 2;7(Suppl 1):29-37. doi: 10.4137/BIC.S25247. eCollection 2015. Review.


Vitamin D and colon cancer.

Klampfer L.

World J Gastrointest Oncol. 2014 Nov 15;6(11):430-7. doi: 10.4251/wjgo.v6.i11.430. Review.


The Role of STAT1 for Crosstalk between Fibroblasts and Colon Cancer Cells.

Kaler P, Owusu BY, Augenlicht L, Klampfer L.

Front Oncol. 2014 Apr 30;4:88. doi: 10.3389/fonc.2014.00088. eCollection 2014.


Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan.

Maitra R, Seetharam R, Tesfa L, Augustine TA, Klampfer L, Coffey MC, Mariadason JM, Goel S.

Oncotarget. 2014 May 15;5(9):2807-19.


K-Ras, intestinal homeostasis and colon cancer.

Goel S, Huang J, Klampfer L.

Curr Clin Pharmacol. 2015;10(1):73-81. Review.


Activating mutations in β-catenin in colon cancer cells alter their interaction with macrophages; the role of snail.

Kaler P, Augenlicht L, Klampfer L.

PLoS One. 2012;7(9):e45462. doi: 10.1371/journal.pone.0045462. Epub 2012 Sep 21.


Cytokines, inflammation and colon cancer.

Klampfer L.

Curr Cancer Drug Targets. 2011 May;11(4):451-64. Review.


Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-1beta-dependent stabilization of Snail in tumor cells.

Kaler P, Galea V, Augenlicht L, Klampfer L.

PLoS One. 2010 Jul 22;5(7):e11700. doi: 10.1371/journal.pone.0011700.


The NF-κB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1β.

Kaler P, Godasi BN, Augenlicht L, Klampfer L.

Cancer Microenviron. 2009 Sep 25;2(1):69-80. doi: 10.1007/s12307-009-0030-y. eCollection 2009 Dec.


Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21.

Escandell JM, Kaler P, Recio MC, Sasazuki T, Shirasawa S, Augenlicht L, Ríos JL, Klampfer L.

Biochem Pharmacol. 2008 Jul 15;76(2):198-207. doi: 10.1016/j.bcp.2008.05.004. Epub 2008 May 8.


PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab.

Jhawer M, Goel S, Wilson AJ, Montagna C, Ling YH, Byun DS, Nasser S, Arango D, Shin J, Klampfer L, Augenlicht LH, Perez-Soler R, Mariadason JM.

Cancer Res. 2008 Mar 15;68(6):1953-61. doi: 10.1158/0008-5472.CAN-07-5659. Erratum in: Cancer Res. 2009 Dec 1;69(23):9156. Cancer Res. 2008 Aug 15;68(16):6859. Soler, Roman Perez [corrected to Perez-Soler, Roman].


HDAC2 deficiency sensitizes colon cancer cells to TNFalpha-induced apoptosis through inhibition of NF-kappaB activity.

Kaler P, Sasazuki T, Shirasawa S, Augenlicht L, Klampfer L.

Exp Cell Res. 2008 Apr 15;314(7):1507-18. doi: 10.1016/j.yexcr.2008.01.010. Epub 2008 Jan 19.


The role of signal transducers and activators of transcription in colon cancer.

Klampfer L.

Front Biosci. 2008 Jan 1;13:2888-99. Review.


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