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Items: 1 to 20 of 61

1.

The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy.

Liu Y, Wang X, Wang G, Yang Y, Yuan Y, Ouyang L.

Eur J Med Chem. 2019 Aug 15;176:92-104. doi: 10.1016/j.ejmech.2019.05.018. Epub 2019 May 8. Review.

PMID:
31100649
2.

New sorbicillinoid derivatives with GLP-1R and eEF2K affinities from a sponge-derived fungus Penicillium chrysogenum 581F1.

Cao MJ, Zhu T, Liu JT, Ouyang L, Yang F, Lin HW.

Nat Prod Res. 2019 Apr 16:1-7. doi: 10.1080/14786419.2019.1596099. [Epub ahead of print]

PMID:
30990084
3.

Deciphering the Rules of in Silico Autophagy Methods for Expediting Medicinal Research.

Chen Y, Wang G, Cai H, Sun Y, Ouyang L, Liu B.

J Med Chem. 2019 Mar 28. doi: 10.1021/acs.jmedchem.8b01673. [Epub ahead of print]

PMID:
30888814
4.

An overview of Sirtuins as potential therapeutic target: Structure, function and modulators.

Wang Y, He J, Liao M, Hu M, Li W, Ouyang H, Wang X, Ye T, Zhang Y, Ouyang L.

Eur J Med Chem. 2019 Jan 1;161:48-77. doi: 10.1016/j.ejmech.2018.10.028. Epub 2018 Oct 15. Review.

PMID:
30342425
5.

Prognostic significance of frequent CLDN18-ARHGAP26/6 fusion in gastric signet-ring cell cancer.

Shu Y, Zhang W, Hou Q, Zhao L, Zhang S, Zhou J, Song X, Zhang Y, Jiang D, Chen X, Wang P, Xia X, Liao F, Yin D, Chen X, Zhou X, Zhang D, Yin S, Yang K, Liu J, Fu L, Zhang L, Wang Y, Zhang J, An Y, Cheng H, Zheng B, Sun H, Zhao Y, Wang Y, Xie D, Ouyang L, Wang P, Zhang W, Qiu M, Fu X, Dai L, He G, Yang H, Cheng W, Yang L, Liu B, Li W, Dong B, Zhou Z, Wei Y, Peng Y, Xu H, Hu J.

Nat Commun. 2018 Jun 30;9(1):2447. doi: 10.1038/s41467-018-04907-0.

6.

Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson's Disease Treatment.

Ouyang L, Zhang L, Zhang S, Yao D, Zhao Y, Wang G, Fu L, Lei P, Liu B.

J Med Chem. 2018 Apr 12;61(7):2776-2792. doi: 10.1021/acs.jmedchem.7b01575. Epub 2018 Mar 29.

PMID:
29561612
7.

UNC-51-like Kinase 1: From an Autophagic Initiator to Multifunctional Drug Target.

Zhang L, Ouyang L, Guo Y, Zhang J, Liu B.

J Med Chem. 2018 Aug 9;61(15):6491-6500. doi: 10.1021/acs.jmedchem.7b01684. Epub 2018 Mar 14.

PMID:
29509411
8.

Recent progress in potential anti-hepatitis B virus agents: Structural and pharmacological perspectives.

Sun D, Zhu L, Yao D, Chen L, Fu L, Ouyang L.

Eur J Med Chem. 2018 Mar 10;147:205-217. doi: 10.1016/j.ejmech.2018.02.001. Epub 2018 Feb 5. Review.

PMID:
29438889
9.

Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy.

Zhang J, Wang G, Zhou Y, Chen Y, Ouyang L, Liu B.

Cell Mol Life Sci. 2018 May;75(10):1803-1826. doi: 10.1007/s00018-018-2759-2. Epub 2018 Feb 7. Review.

PMID:
29417176
10.

Design, synthesis and structure-activity relationship of a focused library of β-phenylalanine derivatives as novel eEF2K inhibitors with apoptosis-inducing mechanisms in breast cancer.

Guo Y, Zhao Y, Wang G, Chen Y, Jiang Y, Ouyang L, Liu B.

Eur J Med Chem. 2018 Jan 1;143:402-418. doi: 10.1016/j.ejmech.2017.11.065. Epub 2017 Dec 1.

PMID:
29202403
11.

Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer.

Ouyang L, Zhang L, Liu J, Fu L, Yao D, Zhao Y, Zhang S, Wang G, He G, Liu B.

J Med Chem. 2017 Dec 28;60(24):9990-10012. doi: 10.1021/acs.jmedchem.7b00275. Epub 2017 Dec 7.

PMID:
29172540
12.

Fluoxetine induces autophagic cell death via eEF2K-AMPK-mTOR-ULK complex axis in triple negative breast cancer.

Sun D, Zhu L, Zhao Y, Jiang Y, Chen L, Yu Y, Ouyang L.

Cell Prolif. 2018 Apr;51(2):e12402. doi: 10.1111/cpr.12402. Epub 2017 Nov 1.

PMID:
29094413
13.

Recent advances in discovery and development of natural products as source for anti-Parkinson's disease lead compounds.

Zhang H, Bai L, He J, Zhong L, Duan X, Ouyang L, Zhu Y, Wang T, Zhang Y, Shi J.

Eur J Med Chem. 2017 Dec 1;141:257-272. doi: 10.1016/j.ejmech.2017.09.068. Epub 2017 Sep 30. Review.

PMID:
29031072
14.

Design, synthesis and structure-activity relationship studies of a focused library of pyrimidine moiety with anti-proliferative and anti-metastasis activities in triple negative breast cancer.

Yao D, Zhou Y, Zhu L, Ouyang L, Zhang J, Jiang Y, Zhao Y, Sun D, Yang S, Yu Y, Wang J.

Eur J Med Chem. 2017 Nov 10;140:155-171. doi: 10.1016/j.ejmech.2017.08.067. Epub 2017 Sep 20.

PMID:
28923383
15.

What structural modifications can be used for BRD4 inhibitors for their use in leukemia therapy?

Yao D, Liu J, Ouyang L.

Future Med Chem. 2017 Jun;9(9):839-842. doi: 10.4155/fmc-2017-0084. Epub 2017 Jun 21. No abstract available.

PMID:
28635318
16.

Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo.

Zhang L, Fu L, Zhang S, Zhang J, Zhao Y, Zheng Y, He G, Yang S, Ouyang L, Liu B.

Chem Sci. 2017 Apr 1;8(4):2687-2701. doi: 10.1039/c6sc05368h. Epub 2017 Jan 9.

17.

Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer.

Fu L, Wang S, Wang X, Wang P, Zheng Y, Yao D, Guo M, Zhang L, Ouyang L.

Sci Rep. 2016 Dec 5;6(1):3. doi: 10.1038/s41598-016-0007-2.

18.

Regulatory network of GATA3 in pediatric acute lymphoblastic leukemia.

Hou Q, Liao F, Zhang S, Zhang D, Zhang Y, Zhou X, Xia X, Ye Y, Yang H, Li Z, Wang L, Wang X, Ma Z, Zhu Y, Ouyang L, Wang Y, Zhang H, Yang L, Xu H, Shu Y.

Oncotarget. 2017 May 30;8(22):36040-36053. doi: 10.18632/oncotarget.16424.

19.

Cimicifoetones A and B, Dimeric Prenylindole Alkaloids as Black Pigments of Cimicifuga foetida.

Zhou CX, Yu YE, Sheng R, Mo JX, Huang M, Ouyang L, Gan LS.

Chem Asian J. 2017 Jun 19;12(12):1277-1281. doi: 10.1002/asia.201700348. Epub 2017 May 11.

PMID:
28393490
20.

A small-molecule activator induces ULK1-modulating autophagy-associated cell death in triple negative breast cancer.

Ouyang L, Zhang L, Fu L, Liu B.

Autophagy. 2017 Apr 3;13(4):777-778. doi: 10.1080/15548627.2017.1283470. Epub 2017 Feb 6.

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