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Int J Mol Sci. 2018 Jul 24;19(8). pii: E2149. doi: 10.3390/ijms19082149.

Tailored Biodegradable and Electroactive Poly(Hydroxybutyrate-Co-Hydroxyvalerate) Based Morphologies for Tissue Engineering Applications.

Author information

1
Center/Department of Physics, Universidade do Minho, 4710-057 Braga, Portugal. luisamaromartins@gmail.com.
2
Center/Department of Chemistry, Universidade de Trás-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal. dcorreia@utad.pt.
3
BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain. dcorreia@utad.pt.
4
Center/Department of Physics, Universidade do Minho, 4710-057 Braga, Portugal. teresaalmeida20@hotmail.com.
5
Center/Department of Physics, Universidade do Minho, 4710-057 Braga, Portugal. pamartins@fisica.uminho.pt.
6
Center/Department of Chemistry, Universidade do Minho, 4710-057 Braga, Portugal. pamartins@fisica.uminho.pt.
7
BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain. leyre.perez@ehu.eus.
8
Macromolecular Chemistry Research Group (labquimac), Department of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain. leyre.perez@ehu.eus.
9
BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain. joseluis.vilas@ehu.eus.
10
Macromolecular Chemistry Research Group (labquimac), Department of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain. joseluis.vilas@ehu.eus.
11
Center/Department of Chemistry, Universidade do Minho, 4710-057 Braga, Portugal. gbotelho@quimica.uminho.pt.
12
BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain. senentxu.lanceros@bcmaterials.net.
13
IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain. senentxu.lanceros@bcmaterials.net.
14
Center/Department of Physics, Universidade do Minho, 4710-057 Braga, Portugal. cribeiro@fisica.uminho.pt.
15
CEB-Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal. cribeiro@fisica.uminho.pt.

Abstract

Polymer-based piezoelectric biomaterials have already proven their relevance for tissue engineering applications. Furthermore, the morphology of the scaffolds plays also an important role in cell proliferation and differentiation. The present work reports on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a biocompatible, biodegradable, and piezoelectric biopolymer that has been processed in different morphologies, including films, fibers, microspheres, and 3D scaffolds. The corresponding magnetically active PHBV-based composites were also produced. The effect of the morphology on physico-chemical, thermal, magnetic, and mechanical properties of pristine and composite samples was evaluated, as well as their cytotoxicity. It was observed that the morphology does not strongly affect the properties of the pristine samples but the introduction of cobalt ferrites induces changes in the degree of crystallinity that could affect the applicability of prepared biomaterials. Young's modulus is dependent of the morphology and also increases with the addition of cobalt ferrites. Both pristine and PHBV/cobalt ferrite composite samples are not cytotoxic, indicating their suitability for tissue engineering applications.

KEYWORDS:

biomaterials; cobalt ferrites; poly(hydroxybutyrate-co-hydroxyvalerate); tissue engineering

PMID:
30042300
PMCID:
PMC6121965
DOI:
10.3390/ijms19082149
[Indexed for MEDLINE]
Free PMC Article

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