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Items: 1 to 20 of 40


Perturbation of Methionine/S-adenosylmethionine Metabolism as a Novel Vulnerability in MLL Rearranged Leukemia.

Barve A, Vega A, Shah PP, Ghare S, Casson L, Wunderlich M, Siskind LJ, Beverly LJ.

Cells. 2019 Oct 25;8(11). pii: E1322. doi: 10.3390/cells8111322.


Computational/experimental evaluation of liver metastasis post hepatic injury: interactions with macrophages and transitional ECM.

Hudson SV, Miller HA, Mahlbacher GE, Saforo D, Beverly LJ, Arteel GE, Frieboes HB.

Sci Rep. 2019 Oct 21;9(1):15077. doi: 10.1038/s41598-019-51249-y.


De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues.

Fan TWM, Bruntz RC, Yang Y, Song H, Chernyavskaya Y, Deng P, Zhang Y, Shah PP, Beverly LJ, Qi Z, Mahan AL, Higashi RM, Dang CV, Lane AN.

J Biol Chem. 2019 Sep 6;294(36):13464-13477. doi: 10.1074/jbc.RA119.008743. Epub 2019 Jul 23.


Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer.

Khan N, Shah PP, Ban D, Trigo-Mouriño P, Carneiro MG, DeLeeuw L, Dean WL, Trent JO, Beverly LJ, Konrad M, Lee D, Sabo TM.

J Biol Chem. 2019 Aug 2;294(31):11920-11933. doi: 10.1074/jbc.RA119.009251. Epub 2019 Jun 14.


Moderate aging does not exacerbate cisplatin-induced kidney injury or fibrosis despite altered inflammatory cytokine expression and immune cell infiltration.

Sharp CN, Doll M, Dupre TV, Beverly LJ, Siskind LJ.

Am J Physiol Renal Physiol. 2019 Jan 1;316(1):F162-F172. doi: 10.1152/ajprenal.00463.2018. Epub 2018 Nov 28.


Comparative utility of NRG and NRGS mice for the study of normal hematopoiesis, leukemogenesis, and therapeutic response.

Barve A, Casson L, Krem M, Wunderlich M, Mulloy JC, Beverly LJ.

Exp Hematol. 2018 Nov;67:18-31. doi: 10.1016/j.exphem.2018.08.004. Epub 2018 Aug 17.


The Antiarrhythmic Drug, Amiodarone, Decreases AKT Activity and Sensitizes Human Acute Myeloid Leukemia Cells to Apoptosis by ABT-263.

Ketchem CJ, Kucera C, Barve A, Beverly LJ.

Am J Med Sci. 2018 May;355(5):488-496. doi: 10.1016/j.amjms.2018.01.011. Epub 2018 Feb 6.


Teaching Old Drugs New Tricks: Repositioning Pharmaceuticals for Bench to Bedside Success.

Beverly LJ, Krem MM.

Am J Med Sci. 2018 Mar;355(3):205-206. doi: 10.1016/j.amjms.2017.12.007. Epub 2017 Dec 26. No abstract available.


Subclinical kidney injury induced by repeated cisplatin administration results in progressive chronic kidney disease.

Sharp CN, Doll MA, Megyesi J, Oropilla GB, Beverly LJ, Siskind LJ.

Am J Physiol Renal Physiol. 2018 Jul 1;315(1):F161-F172. doi: 10.1152/ajprenal.00636.2017. Epub 2018 Jan 31.


Regulation of insulin-like growth factor receptors by Ubiquilin1.

Kurlawala Z, Dunaway R, Shah PP, Gosney JA, Siskind LJ, Ceresa BP, Beverly LJ.

Biochem J. 2017 Dec 6;474(24):4105-4118. doi: 10.1042/BCJ20170620.


Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.

Dupre TV, Doll MA, Shah PP, Sharp CN, Siow D, Megyesi J, Shayman J, Bielawska A, Bielawski J, Beverly LJ, Hernandez-Corbacho M, Clarke CJ, Snider AJ, Schnellmann RG, Obeid LM, Hannun YA, Siskind LJ.

J Lipid Res. 2017 Jul;58(7):1439-1452. doi: 10.1194/jlr.M076745. Epub 2017 May 10.


MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis.

Yadav S, Singh N, Shah PP, Rowbotham DA, Malik D, Srivastav A, Shankar J, Lam WL, Lockwood WW, Beverly LJ.

Neoplasia. 2017 Apr;19(4):321-332. doi: 10.1016/j.neo.2017.02.001. Epub 2017 Mar 16.


Common cytotoxic chemotherapeutics induce epithelial-mesenchymal transition (EMT) downstream of ER stress.

Shah PP, Dupre TV, Siskind LJ, Beverly LJ.

Oncotarget. 2017 Apr 4;8(14):22625-22639. doi: 10.18632/oncotarget.15150.


The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.

Kurlawala Z, Shah PP, Shah C, Beverly LJ.

J Cell Biochem. 2017 Aug;118(8):2261-2270. doi: 10.1002/jcb.25880. Epub 2017 Apr 25.


Methods to Study Metastasis in Genetically Modified Mice.

Kabeer F, Beverly LJ, Darrasse-Jèze G, Podsypanina K.

Cold Spring Harb Protoc. 2016 Feb 1;2016(2):pdb.top069948. doi: 10.1101/pdb.top069948.


Murine Stem Cell-Based Retrovirus Production for Marking Primary Mouse Mammary Cells for Metastasis Studies.

Beverly LJ, Podsypanina K.

Cold Spring Harb Protoc. 2016 Feb 1;2016(2):pdb.prot078337. doi: 10.1101/pdb.prot078337.


Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.

Sundaram K, Mather AR, Marimuthu S, Shah PP, Snider AJ, Obeid LM, Hannun YA, Beverly LJ, Siskind LJ.

Biochem J. 2016 Mar 15;473(6):743-55. doi: 10.1042/BJ20150586. Epub 2016 Jan 8.


Repeated administration of low-dose cisplatin in mice induces fibrosis.

Sharp CN, Doll MA, Dupre TV, Shah PP, Subathra M, Siow D, Arteel GE, Megyesi J, Beverly LJ, Siskind LJ.

Am J Physiol Renal Physiol. 2016 Mar 15;310(6):F560-8. doi: 10.1152/ajprenal.00512.2015. Epub 2016 Jan 6.


Suramin protects from cisplatin-induced acute kidney injury.

Dupre TV, Doll MA, Shah PP, Sharp CN, Kiefer A, Scherzer MT, Saurabh K, Saforo D, Siow D, Casson L, Arteel GE, Jenson AB, Megyesi J, Schnellmann RG, Beverly LJ, Siskind LJ.

Am J Physiol Renal Physiol. 2016 Feb 1;310(3):F248-58. doi: 10.1152/ajprenal.00433.2015. Epub 2015 Dec 9.


Ceramide channels: destabilization by Bcl-xL and role in apoptosis.

Chang KT, Anishkin A, Patwardhan GA, Beverly LJ, Siskind LJ, Colombini M.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2374-84. doi: 10.1016/j.bbamem.2015.07.013. Epub 2015 Jul 26.

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