Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 37

1.

Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.

Purgatorio R, de Candia M, Catto M, Carrieri A, Pisani L, De Palma A, Toma M, Ivanova OA, Voskressensky LG, Altomare CD.

Eur J Med Chem. 2019 Sep 1;177:414-424. doi: 10.1016/j.ejmech.2019.05.062. Epub 2019 May 28.

PMID:
31158754
2.

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.

Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M, Pisani L, Denora N, Iacobazzi RM, Silman I, Sussman JL, Buron F, Colletier JP, Jean L, Routier S, Renard PY.

Eur J Med Chem. 2019 Apr 15;168:58-77. doi: 10.1016/j.ejmech.2018.12.063. Epub 2019 Feb 13.

3.

Imaging of Unusual Renal Tumors.

Castillo RP, Santoscoy JF, Pisani L, Madrazo BL, Casillas VJ.

Curr Urol Rep. 2019 Jan 21;20(1):5. doi: 10.1007/s11934-019-0867-7. Review.

PMID:
30663008
4.

1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1.

Rullo M, Niso M, Pisani L, Carrieri A, Colabufo NA, Cellamare S, Altomare CD.

Eur J Med Chem. 2019 Jan 1;161:433-444. doi: 10.1016/j.ejmech.2018.10.043. Epub 2018 Oct 18.

PMID:
30384046
5.

Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.

Pisani L, Iacobazzi RM, Catto M, Rullo M, Farina R, Denora N, Cellamare S, Altomare CD.

Eur J Med Chem. 2019 Jan 1;161:292-309. doi: 10.1016/j.ejmech.2018.10.016. Epub 2018 Oct 10.

PMID:
30366255
6.

Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity.

Purgatorio R, de Candia M, De Palma A, De Santis F, Pisani L, Campagna F, Cellamare S, Altomare CD, Catto M.

Molecules. 2018 Jun 26;23(7). pii: E1544. doi: 10.3390/molecules23071544.

7.

Causes of mortality in early infantile epileptic encephalopathy: A systematic review.

Radaelli G, de Souza Santos F, Borelli WV, Pisani L, Nunes ML, Scorza FA, da Costa JC.

Epilepsy Behav. 2018 Aug;85:32-36. doi: 10.1016/j.yebeh.2018.05.015. Epub 2018 Jun 13.

PMID:
29906699
8.

Neurobiological findings associated with high cognitive performance in older adults: a systematic review.

Borelli WV, Schilling LP, Radaelli G, Ferreira LB, Pisani L, Portuguez MW, da Costa JC.

Int Psychogeriatr. 2018 Dec;30(12):1813-1825. doi: 10.1017/S1041610218000431. Epub 2018 Apr 18.

PMID:
29667572
9.

Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors.

Mangiatordi GF, Trisciuzzi D, Iacobazzi R, Denora N, Pisani L, Catto M, Leonetti F, Alberga D, Nicolotti O.

Chem Biol Drug Des. 2018 Jul;92(1):1161-1170. doi: 10.1111/cbdd.13200. Epub 2018 Apr 27.

PMID:
29633572
10.

Structure-property relationship study of the HPLC enantioselective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase.

Pisani L, Rullo M, Catto M, de Candia M, Carrieri A, Cellamare S, Altomare CD.

J Sep Sci. 2018 Mar;41(6):1376-1384. doi: 10.1002/jssc.201701442.

PMID:
29419937
11.

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds.

Stefanachi A, Leonetti F, Pisani L, Catto M, Carotti A.

Molecules. 2018 Jan 27;23(2). pii: E250. doi: 10.3390/molecules23020250. Review.

12.

Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl)hydrazone: A water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity.

Pisani L, De Palma A, Giangregorio N, Miniero DV, Pesce P, Nicolotti O, Campagna F, Altomare CD, Catto M.

Eur J Pharm Sci. 2017 Nov 15;109:381-388. doi: 10.1016/j.ejps.2017.08.004. Epub 2017 Aug 9.

PMID:
28801274
13.

Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs.

Napolitano L, Scalise M, Koyioni M, Koutentis P, Catto M, Eberini I, Parravicini C, Palazzolo L, Pisani L, Galluccio M, Console L, Carotti A, Indiveri C.

Biochem Pharmacol. 2017 Nov 1;143:39-52. doi: 10.1016/j.bcp.2017.07.006. Epub 2017 Jul 12.

PMID:
28709952
14.

Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties.

Pisani L, Catto M, De Palma A, Farina R, Cellamare S, Altomare CD.

ChemMedChem. 2017 Aug 22;12(16):1349-1358. doi: 10.1002/cmdc.201700282. Epub 2017 Jun 29.

PMID:
28570763
15.

A rational approach to elucidate human monoamine oxidase molecular selectivity.

Mangiatordi GF, Alberga D, Pisani L, Gadaleta D, Trisciuzzi D, Farina R, Carotti A, Lattanzi G, Catto M, Nicolotti O.

Eur J Pharm Sci. 2017 Apr 1;101:90-99. doi: 10.1016/j.ejps.2017.02.008. Epub 2017 Feb 7.

PMID:
28188911
16.

Mind the Gap! A Journey towards Computational Toxicology.

Mangiatordi GF, Alberga D, Altomare CD, Carotti A, Catto M, Cellamare S, Gadaleta D, Lattanzi G, Leonetti F, Pisani L, Stefanachi A, Trisciuzzi D, Nicolotti O.

Mol Inform. 2016 Sep;35(8-9):294-308. doi: 10.1002/minf.201501017. Epub 2016 Apr 13. Review.

PMID:
27546034
17.

Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.

Pisani L, Farina R, Catto M, Iacobazzi RM, Nicolotti O, Cellamare S, Mangiatordi GF, Denora N, Soto-Otero R, Siragusa L, Altomare CD, Carotti A.

J Med Chem. 2016 Jul 28;59(14):6791-806. doi: 10.1021/acs.jmedchem.6b00562. Epub 2016 Jul 7.

PMID:
27347731
18.

Searching for Multi-Targeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif.

Pisani L, Farina R, Soto-Otero R, Denora N, Mangiatordi GF, Nicolotti O, Mendez-Alvarez E, Altomare CD, Catto M, Carotti A.

Molecules. 2016 Mar 17;21(3):362. doi: 10.3390/molecules21030362.

19.

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.

Farina R, Pisani L, Catto M, Nicolotti O, Gadaleta D, Denora N, Soto-Otero R, Mendez-Alvarez E, Passos CS, Muncipinto G, Altomare CD, Nurisso A, Carrupt PA, Carotti A.

J Med Chem. 2015 Jul 23;58(14):5561-78. doi: 10.1021/acs.jmedchem.5b00599. Epub 2015 Jul 9.

PMID:
26107513
20.

Multitarget-directed tricyclic pyridazinones as G protein-coupled receptor ligands and cholinesterase inhibitors.

Pau A, Catto M, Pinna G, Frau S, Murineddu G, Asproni B, Curzu MM, Pisani L, Leonetti F, Loza MI, Brea J, Pinna GA, Carotti A.

ChemMedChem. 2015 Jun;10(6):1054-70. doi: 10.1002/cmdc.201500124. Epub 2015 Apr 29.

PMID:
25924828

Supplemental Content

Loading ...
Support Center