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Items: 1 to 20 of 21


Cytotoxicity of hexahelicene and its effect on the aryl hydrocarbon receptor pathway.

Vrba J, Roubalova L, Cirkva V, Storch J, Vacek J.

Toxicol In Vitro. 2019 Jun;57:105-109. doi: 10.1016/j.tiv.2019.02.020. Epub 2019 Feb 26.


Na+/K+-ATPase level and products of lipid peroxidation in live cells treated with therapeutic lithium for different periods in time (1, 7, and 28 days); studies of Jurkat and HEK293 cells.

Vosahlikova M, Roubalova L, Ujcikova H, Hlouskova M, Musil S, Alda M, Svoboda P.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Jul;392(7):785-799. doi: 10.1007/s00210-019-01631-4. Epub 2019 Feb 21.


Corrigendum to "Induction of oxidative stress by long-term treatment of live HEK293 cells with therapeutic concentration of lithium is associated with down-regulation of δ-opioid receptor amount and function" [Biochem. Pharmacol. 154 (2018) 452-463].

Vosahlikova M, Ujcikova H, Hlouskova M, Musil S, Roubalova L, Alda M, Svoboda P.

Biochem Pharmacol. 2018 Oct;156:396-397. doi: 10.1016/j.bcp.2018.09.001. Epub 2018 Sep 13. No abstract available.


Sulfated Metabolites of Flavonolignans and 2,3-Dehydroflavonolignans: Preparation and Properties.

Valentová K, Purchartová K, Rydlová L, Roubalová L, Biedermann D, Petrásková L, Křenková A, Pelantová H, Holečková-Moravcová V, Tesařová E, Cvačka J, Vrba J, Ulrichová J, Křen V.

Int J Mol Sci. 2018 Aug 9;19(8). pii: E2349. doi: 10.3390/ijms19082349.


Up-regulation of μ-, δ- and κ-opioid receptors in concanavalin A-stimulated rat spleen lymphocytes.

Cechova K, Hlouskova M, Javorkova E, Roubalova L, Ujcikova H, Holan V, Svoboda P.

J Neuroimmunol. 2018 Aug 15;321:12-23. doi: 10.1016/j.jneuroim.2018.05.008. Epub 2018 May 21.


Induction of oxidative stress by long-term treatment of live HEK293 cells with therapeutic concentration of lithium is associated with down-regulation of δ-opioid receptor amount and function.

Vosahlikova M, Ujcikova H, Hlouskova M, Musil S, Roubalova L, Alda M, Svoboda P.

Biochem Pharmacol. 2018 Aug;154:452-463. doi: 10.1016/j.bcp.2018.06.004. Epub 2018 Jun 5. Erratum in: Biochem Pharmacol. 2018 Oct;156:396-397.


Metabolism of flavonolignans in human hepatocytes.

Vrba J, Papoušková B, Roubalová L, Zatloukalová M, Biedermann D, Křen V, Valentová K, Ulrichová J, Vacek J.

J Pharm Biomed Anal. 2018 Apr 15;152:94-101. doi: 10.1016/j.jpba.2018.01.048. Epub 2018 Jan 31.


Determination of μ-, δ- and κ-opioid receptors in forebrain cortex of rats exposed to morphine for 10 days: Comparison with animals after 20 days of morphine withdrawal.

Ujcikova H, Hlouskova M, Cechova K, Stolarova K, Roubalova L, Svoboda P.

PLoS One. 2017 Oct 20;12(10):e0186797. doi: 10.1371/journal.pone.0186797. eCollection 2017.


Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells.

Roubalová L, Dinkova-Kostova AT, Biedermann D, Křen V, Ulrichová J, Vrba J.

Fitoterapia. 2017 Jun;119:115-120. doi: 10.1016/j.fitote.2017.04.012. Epub 2017 Apr 24.


Effect of therapeutic concentration of lithium on live HEK293 cells; increase of Na+/K+-ATPase, change of overall protein composition and alteration of surface layer of plasma membrane.

Vosahlikova M, Ujcikova H, Chernyavskiy O, Brejchova J, Roubalova L, Alda M, Svoboda P.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):1099-1112. doi: 10.1016/j.bbagen.2017.02.011. Epub 2017 Feb 13.


Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells.

Roubalová L, Biedermann D, Papoušková B, Vacek J, Kuzma M, Křen V, Ulrichová J, Dinkova-Kostova AT, Vrba J.

Chem Biol Interact. 2016 Dec 25;260:58-66. doi: 10.1016/j.cbi.2016.10.015. Epub 2016 Oct 21.


Protective effect of isoquercitrin against acute dextran sulfate sodium-induced rat colitis depends on the severity of tissue damage.

Cibiček N, Roubalová L, Vrba J, Zatloukalová M, Ehrmann J, Zapletalová J, Večeřa R, Křen V, Ulrichová J.

Pharmacol Rep. 2016 Dec;68(6):1197-1204. doi: 10.1016/j.pharep.2016.07.007. Epub 2016 Sep 19.


Plasma membrane cholesterol level and agonist-induced internalization of δ-opioid receptors; colocalization study with intracellular membrane markers of Rab family.

Brejchova J, Vosahlikova M, Roubalova L, Parenti M, Mauri M, Chernyavskiy O, Svoboda P.

J Bioenerg Biomembr. 2016 Aug;48(4):375-96. doi: 10.1007/s10863-016-9667-7. Epub 2016 Jul 13.


Proteomic analysis of protein composition of rat forebrain cortex exposed to morphine for 10days; comparison with animals exposed to morphine and subsequently nurtured for 20days in the absence of this drug.

Ujcikova H, Vosahlikova M, Roubalova L, Svoboda P.

J Proteomics. 2016 Aug 11;145:11-23. doi: 10.1016/j.jprot.2016.02.019. Epub 2016 Feb 26.


High Efficacy but Low Potency of δ-Opioid Receptor-G Protein Coupling in Brij-58-Treated, Low-Density Plasma Membrane Fragments.

Roubalova L, Vosahlikova M, Brejchova J, Sykora J, Rudajev V, Svoboda P.

PLoS One. 2015 Aug 18;10(8):e0135664. doi: 10.1371/journal.pone.0135664. eCollection 2015.


Sulfation modulates the cell uptake, antiradical activity and biological effects of flavonoids in vitro: An examination of quercetin, isoquercitrin and taxifolin.

Roubalová L, Purchartová K, Papoušková B, Vacek J, Křen V, Ulrichová J, Vrba J.

Bioorg Med Chem. 2015 Sep 1;23(17):5402-9. doi: 10.1016/j.bmc.2015.07.055. Epub 2015 Jul 29.


TRH-receptor mobility and function in intact and cholesterol-depleted plasma membrane of HEK293 cells stably expressing TRH-R-eGFP.

Brejchová J, Sýkora J, Ostašov P, Merta L, Roubalová L, Janáček J, Hof M, Svoboda P.

Biochim Biophys Acta. 2015 Mar;1848(3):781-96. doi: 10.1016/j.bbamem.2014.11.029. Epub 2014 Dec 6.


High- and low-affinity sites for sodium in δ-OR-Gi1α (Cys (351)-Ile (351)) fusion protein stably expressed in HEK293 cells; functional significance and correlation with biophysical state of plasma membrane.

Vošahlíková M, Jurkiewicz P, Roubalová L, Hof M, Svoboda P.

Naunyn Schmiedebergs Arch Pharmacol. 2014 May;387(5):487-502. doi: 10.1007/s00210-014-0962-8. Epub 2014 Mar 1.


Proteomic analysis of post-nuclear supernatant fraction and percoll-purified membranes prepared from brain cortex of rats exposed to increasing doses of morphine.

Ujcikova H, Eckhardt A, Kagan D, Roubalova L, Svoboda P.

Proteome Sci. 2014 Feb 14;12(1):11. doi: 10.1186/1477-5956-12-11.


Up-regulation of adenylylcyclases I and II induced by long-term adaptation of rats to morphine fades away 20 days after morphine withdrawal.

Ujcikova H, Dlouha K, Roubalova L, Vosahlikova M, Kagan D, Svoboda P.

Biochim Biophys Acta. 2011 Dec;1810(12):1220-9. doi: 10.1016/j.bbagen.2011.09.017. Epub 2011 Oct 4.


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