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Items: 1 to 20 of 21

1.

Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K2P Channels.

Bustos D, Bedoya M, Ramírez D, Concha G, Zúñiga L, Decher N, Hernández-Rodríguez EW, Sepúlveda FV, Martínez L, González W.

Int J Mol Sci. 2020 Jan 14;21(2). pii: E532. doi: 10.3390/ijms21020532.

PMID:
31947679
2.

TASK-3 Gene Knockdown Dampens Invasion and Migration and Promotes Apoptosis in KATO III and MKN-45 Human Gastric Adenocarcinoma Cell Lines.

Cikutović-Molina R, Herrada AA, González W, Brown N, Zúñiga L.

Int J Mol Sci. 2019 Dec 2;20(23). pii: E6077. doi: 10.3390/ijms20236077.

3.

Correction: Concha, G., et al. The Insensitivity of TASK-3 K2P Channels to External Tetraethylammonium (TEA) Partially Depends on the Cap Structure. Int. J. Mol. Sci. 2018, 19, 2437.

Concha G, Bustos D, Zúñiga R, Catalán MA, Zúñiga L.

Int J Mol Sci. 2019 Sep 19;20(18). pii: E4651. doi: 10.3390/ijms20184651.

4.

Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening.

Ramírez D, Concha G, Arévalo B, Prent-Peñaloza L, Zúñiga L, Kiper AK, Rinné S, Reyes-Parada M, Decher N, González W, Caballero J.

Int J Mol Sci. 2019 Aug 17;20(16). pii: E4014. doi: 10.3390/ijms20164014.

5.

HCN Channels: New Therapeutic Targets for Pain Treatment.

Ramírez D, Zúñiga R, Concha G, Zúñiga L.

Molecules. 2018 Aug 21;23(9). pii: E2094. doi: 10.3390/molecules23092094. Review.

6.

The Insensitivity of TASK-3 K₂P Channels to External Tetraethylammonium (TEA) Partially Depends on the Cap Structure.

Concha G, Bustos D, Zúñiga R, Catalán MA, Zúñiga L.

Int J Mol Sci. 2018 Aug 18;19(8). pii: E2437. doi: 10.3390/ijms19082437. Erratum in: Int J Mol Sci. 2019 Sep 19;20(18):.

7.

TASK-3 Downregulation Triggers Cellular Senescence and Growth Inhibition in Breast Cancer Cell Lines.

Zúñiga R, Valenzuela C, Concha G, Brown N, Zúñiga L.

Int J Mol Sci. 2018 Mar 29;19(4). pii: E1033. doi: 10.3390/ijms19041033.

8.

Insulin Induces Relaxation and Decreases Hydrogen Peroxide-Induced Vasoconstriction in Human Placental Vascular Bed in a Mechanism Mediated by Calcium-Activated Potassium Channels and L-Arginine/Nitric Oxide Pathways.

Cabrera L, Saavedra A, Rojas S, Cid M, Valenzuela C, Gallegos D, Careaga P, Basualto E, Haensgen A, Peña E, Rivas C, Vera JC, Gallardo V, Zúñiga L, Escudero C, Sobrevia L, Wareing M, González M.

Front Physiol. 2016 Nov 22;7:529. eCollection 2016.

9.

Expression and cellular localization of HCN channels in rat cerebellar granule neurons.

Zúñiga R, González D, Valenzuela C, Brown N, Zúñiga L.

Biochem Biophys Res Commun. 2016 Sep 23;478(3):1429-35. doi: 10.1016/j.bbrc.2016.08.141. Epub 2016 Aug 25.

PMID:
27569278
10.

Understanding the Cap Structure in K2P Channels.

Zúñiga L, Zúñiga R.

Front Physiol. 2016 Jun 14;7:228. doi: 10.3389/fphys.2016.00228. eCollection 2016. No abstract available.

11.

Cardiovascular Action of Insulin in Health and Disease: Endothelial L-Arginine Transport and Cardiac Voltage-Dependent Potassium Channels.

Dubó S, Gallegos D, Cabrera L, Sobrevia L, Zúñiga L, González M.

Front Physiol. 2016 Mar 15;7:74. doi: 10.3389/fphys.2016.00074. eCollection 2016. Review.

12.

K₂p channels in plants and animals.

González W, Valdebenito B, Caballero J, Riadi G, Riedelsberger J, Martínez G, Ramírez D, Zúñiga L, Sepúlveda FV, Dreyer I, Janta M, Becker D.

Pflugers Arch. 2015 May;467(5):1091-104. doi: 10.1007/s00424-014-1638-4. Epub 2014 Nov 6. Review.

PMID:
25369776
13.

Differential expression of two-pore domain potassium channels in rat cerebellar granule neurons.

Burgos P, Zúñiga R, Domínguez P, Delgado-López F, Plant LD, Zúñiga L.

Biochem Biophys Res Commun. 2014 Oct 31;453(4):754-60. doi: 10.1016/j.bbrc.2014.10.012. Epub 2014 Oct 12.

PMID:
25305496
14.

An extracellular ion pathway plays a central role in the cooperative gating of a K(2P) K+ channel by extracellular pH.

González W, Zúñiga L, Cid LP, Arévalo B, Niemeyer MI, Sepúlveda FV.

J Biol Chem. 2013 Feb 22;288(8):5984-91. doi: 10.1074/jbc.M112.445528. Epub 2013 Jan 14.

15.

SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.

Plant LD, Zuniga L, Araki D, Marks JD, Goldstein SA.

Sci Signal. 2012 Nov 20;5(251):ra84. doi: 10.1126/scisignal.2003431.

16.

Gating of a pH-sensitive K(2P) potassium channel by an electrostatic effect of basic sensor residues on the selectivity filter.

Zúñiga L, Márquez V, González-Nilo FD, Chipot C, Cid LP, Sepúlveda FV, Niemeyer MI.

PLoS One. 2011 Jan 25;6(1):e16141. doi: 10.1371/journal.pone.0016141.

17.

Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval.

Cornejo I, Niemeyer MI, Zúñiga L, Yusef YR, Sepúlveda FV, Cid LP.

J Cell Physiol. 2009 Dec;221(3):650-7. doi: 10.1002/jcp.21900.

PMID:
19711355
18.

Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel.

Niemeyer MI, González-Nilo FD, Zúñiga L, González W, Cid LP, Sepúlveda FV.

Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):666-71. Epub 2006 Dec 29.

19.

Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain.

Yusef YR, Zúñiga L, Catalán M, Niemeyer MI, Cid LP, Sepúlveda FV.

J Physiol. 2006 Apr 1;572(Pt 1):173-81. Epub 2006 Feb 9.

20.

The voltage-dependent ClC-2 chloride channel has a dual gating mechanism.

Zúñiga L, Niemeyer MI, Varela D, Catalán M, Cid LP, Sepúlveda FV.

J Physiol. 2004 Mar 16;555(Pt 3):671-82. Epub 2004 Jan 14.

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