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Front Vet Sci. 2016 Sep 16;3:81. eCollection 2016.

A Prospective, Randomized, Masked, and Placebo-Controlled Efficacy Study of Intraarticular Allogeneic Adipose Stem Cells for the Treatment of Osteoarthritis in Dogs.

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VetStem Biopharma, Inc. , Poway, CA , USA.
VCA Bay Area Veterinary Specialists , San Leandro, CA , USA.
Peak Performance Veterinary Group , Frisco, CO , USA.
Surgery 4 Pets , Portland, OR , USA.
California Veterinary Specialists , Carlsbad, CA , USA.
Burnt Hills Veterinary Hospital , Burnt Hills, NY , USA.
Garden State Veterinary Specialists , Tinton Falls, NJ , USA.
Cascade Veterinary Referral Center , Tigard, OR , USA.
Animal Medical Center of New York , New York, NY , USA.
Integrative Sports Rehab and Wellness LLC , Foxfield, CO , USA.


Osteoarthritis (OA) is a degenerative joint disease with a high prevalence in dogs. Mesenchymal stem cells (MSCs) have been used to treat humans, dogs, and horses with OA. This report describes a prospective, randomized, blinded, and placebo-controlled clinical efficacy study of intraarticular allogeneic adipose stem cells for the treatment of dogs with OA. Health assessments and measurements of pain and activity impairment were performed at baseline and at selected time points through day 60. The primary outcome variable was the owner Client-Specific Outcome Measurement (CSOM) and secondary measures included veterinary pain on manipulation, veterinary global score, and owner global score. The dogs were treated with either a saline placebo or a single dose of allogeneic adipose-derived MSCs in either one or two joints. Seventy-four dogs were statistically analyzed for efficacy outcomes. Success in the primary outcome variable, CSOM, was statistically improved in the treated dogs compared to the placebo dogs (79.2 versus 55.4%, p = 0.029). The veterinary pain on manipulation score (92.8 versus 50.2%, p = 0.017) and the veterinary global score (86.9 versus 30.8%, p = 0.009) were both statistically improved in treated dogs compared to placebo. There was no detected significant difference between treated and placebo dogs in the incidence of adverse events or negative health findings. Allogeneic adipose-derived stem cell treatment was shown to be efficacious compared to placebo. This large study of dogs also provides valuable animal clinical safety and efficacy outcome data to our colleagues developing human stem cell therapy.


adipose stem cells; adult stem cells; arthritis; clinical translation; dog model; mesenchymal stem cells

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