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Items: 1 to 20 of 131


Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody.

Giddens JP, Lomino JV, DiLillo DJ, Ravetch JV, Wang LX.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12023-12027. doi: 10.1073/pnas.1812833115. Epub 2018 Nov 5.


Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-Dependent Antibodies with Promiscuous Site Recognition.

Cai H, Zhang RS, Orwenyo J, Giddens J, Yang Q, LaBranche CC, Montefiori DC, Wang LX.

J Med Chem. 2018 Nov 21;61(22):10116-10125. doi: 10.1021/acs.jmedchem.8b01290. Epub 2018 Nov 8.


Chemoenzymatic Defucosylation of Therapeutic Antibodies for Enhanced Effector Functions Using Bacterial α-Fucosidases.

Li C, Li T, Wang LX.

Methods Mol Biol. 2018;1827:367-380. doi: 10.1007/978-1-4939-8648-4_19.


Chemoenzymatic Methods for the Synthesis of Glycoproteins.

Li C, Wang LX.

Chem Rev. 2018 Sep 12;118(17):8359-8413. doi: 10.1021/acs.chemrev.8b00238. Epub 2018 Aug 24.


Generation and Comparative Kinetic Analysis of New Glycosynthase Mutants from Streptococcus pyogenes Endoglycosidases for Antibody Glycoengineering.

Tong X, Li T, Li C, Wang LX.

Biochemistry. 2018 Sep 4;57(35):5239-5246. doi: 10.1021/acs.biochem.8b00719. Epub 2018 Aug 22.


The Odd "RB" Phage-Identification of Arabinosylation as a New Epigenetic Modification of DNA in T4-Like Phage RB69.

Thomas JA, Orwenyo J, Wang LX, Black LW.

Viruses. 2018 Jun 8;10(6). pii: E313. doi: 10.3390/v10060313.


Multivalent Antigen Presentation Enhances the Immunogenicity of a Synthetic Three-Component HIV-1 V3 Glycopeptide Vaccine.

Cai H, Zhang R, Orwenyo J, Giddens J, Yang Q, LaBranche CC, Montefiori DC, Wang LX.

ACS Cent Sci. 2018 May 23;4(5):582-589. doi: 10.1021/acscentsci.8b00060. Epub 2018 May 7.


Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S.

Trastoy B, Klontz E, Orwenyo J, Marina A, Wang LX, Sundberg EJ, Guerin ME.

Nat Commun. 2018 May 14;9(1):1874. doi: 10.1038/s41467-018-04300-x.


Top-Down Chemoenzymatic Approach to Synthesizing Diverse High-Mannose N-Glycans and Related Neoglycoproteins for Carbohydrate Microarray Analysis.

Toonstra C, Wu L, Li C, Wang D, Wang LX.

Bioconjug Chem. 2018 Jun 20;29(6):1911-1921. doi: 10.1021/acs.bioconjchem.8b00145. Epub 2018 May 22.


Site-specific immobilization of endoglycosidases for streamlined chemoenzymatic glycan remodeling of antibodies.

Li T, Li C, Quan DN, Bentley WE, Wang LX.

Carbohydr Res. 2018 Mar 22;458-459:77-84. doi: 10.1016/j.carres.2018.02.007. Epub 2018 Feb 15.


Implementation of Glycan Remodeling to Plant-Made Therapeutic Antibodies.

Bennett LD, Yang Q, Berquist BR, Giddens JP, Ren Z, Kommineni V, Murray RP, White EL, Holtz BR, Wang LX, Marcel S.

Int J Mol Sci. 2018 Jan 31;19(2). pii: E421. doi: 10.3390/ijms19020421.


Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses.

Cai H, Orwenyo J, Giddens JP, Yang Q, Zhang R, LaBranche CC, Montefiori DC, Wang LX.

Cell Chem Biol. 2017 Dec 21;24(12):1513-1522.e4. doi: 10.1016/j.chembiol.2017.09.005. Epub 2017 Oct 26.


Designer α1,6-Fucosidase Mutants Enable Direct Core Fucosylation of Intact N-Glycopeptides and N-Glycoproteins.

Li C, Zhu S, Ma C, Wang LX.

J Am Chem Soc. 2017 Oct 25;139(42):15074-15087. doi: 10.1021/jacs.7b07906. Epub 2017 Oct 16.


Chemoenzymatic Glycan Remodeling of Natural and Recombinant Glycoproteins.

Yang Q, Wang LX.

Methods Enzymol. 2017;597:265-281. doi: 10.1016/bs.mie.2017.06.006. Epub 2017 Jul 5.


One-pot enzymatic glycan remodeling of a therapeutic monoclonal antibody by endoglycosidase S (Endo-S) from Streptococcus pyogenes.

Tong X, Li T, Orwenyo J, Toonstra C, Wang LX.

Bioorg Med Chem. 2018 Apr 1;26(7):1347-1355. doi: 10.1016/j.bmc.2017.07.053. Epub 2017 Jul 29.


Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody-drug conjugates.

Tang F, Wang LX, Huang W.

Nat Protoc. 2017 Aug;12(8):1702-1721. doi: 10.1038/nprot.2017.058. Epub 2017 Jul 27.


Revisiting the substrate specificity of mammalian α1,6-fucosyltransferase reveals that it catalyzes core fucosylation of N-glycans lacking α1,3-arm GlcNAc.

Yang Q, Zhang R, Cai H, Wang LX.

J Biol Chem. 2017 Sep 8;292(36):14796-14803. doi: 10.1074/jbc.M117.804070. Epub 2017 Jul 20.


Conformational Heterogeneity of the HIV Envelope Glycan Shield.

Yang M, Huang J, Simon R, Wang LX, MacKerell AD Jr.

Sci Rep. 2017 Jun 30;7(1):4435. doi: 10.1038/s41598-017-04532-9.


Antibody against Microbial Neuraminidases Recognizes Human Sialidase 3 (NEU3): the Neuraminidase/Sialidase Superfamily Revisited.

Feng C, Li J, Snyder G, Huang W, Goldblum SE, Chen WH, Wang LX, McClane BA, Cross AS.

MBio. 2017 Jun 27;8(3). pii: e00078-17. doi: 10.1128/mBio.00078-17.


Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies.

Cai H, Orwenyo J, Guenaga J, Giddens J, Toonstra C, Wyatt RT, Wang LX.

Chem Commun (Camb). 2017 May 14;53(39):5453-5456. doi: 10.1039/c7cc02059g. Epub 2017 May 3.

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