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Items: 1 to 20 of 131

1.

Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody.

Giddens JP, Lomino JV, DiLillo DJ, Ravetch JV, Wang LX.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12023-12027. doi: 10.1073/pnas.1812833115. Epub 2018 Nov 5.

PMID:
30397147
2.

Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-Dependent Antibodies with Promiscuous Site Recognition.

Cai H, Zhang RS, Orwenyo J, Giddens J, Yang Q, LaBranche CC, Montefiori DC, Wang LX.

J Med Chem. 2018 Nov 21;61(22):10116-10125. doi: 10.1021/acs.jmedchem.8b01290. Epub 2018 Nov 8.

PMID:
30384610
3.

Chemoenzymatic Defucosylation of Therapeutic Antibodies for Enhanced Effector Functions Using Bacterial α-Fucosidases.

Li C, Li T, Wang LX.

Methods Mol Biol. 2018;1827:367-380. doi: 10.1007/978-1-4939-8648-4_19.

4.

Chemoenzymatic Methods for the Synthesis of Glycoproteins.

Li C, Wang LX.

Chem Rev. 2018 Sep 12;118(17):8359-8413. doi: 10.1021/acs.chemrev.8b00238. Epub 2018 Aug 24.

PMID:
30141327
5.

Generation and Comparative Kinetic Analysis of New Glycosynthase Mutants from Streptococcus pyogenes Endoglycosidases for Antibody Glycoengineering.

Tong X, Li T, Li C, Wang LX.

Biochemistry. 2018 Sep 4;57(35):5239-5246. doi: 10.1021/acs.biochem.8b00719. Epub 2018 Aug 22.

PMID:
30102520
6.

The Odd "RB" Phage-Identification of Arabinosylation as a New Epigenetic Modification of DNA in T4-Like Phage RB69.

Thomas JA, Orwenyo J, Wang LX, Black LW.

Viruses. 2018 Jun 8;10(6). pii: E313. doi: 10.3390/v10060313.

7.

Multivalent Antigen Presentation Enhances the Immunogenicity of a Synthetic Three-Component HIV-1 V3 Glycopeptide Vaccine.

Cai H, Zhang R, Orwenyo J, Giddens J, Yang Q, LaBranche CC, Montefiori DC, Wang LX.

ACS Cent Sci. 2018 May 23;4(5):582-589. doi: 10.1021/acscentsci.8b00060. Epub 2018 May 7.

8.

Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S.

Trastoy B, Klontz E, Orwenyo J, Marina A, Wang LX, Sundberg EJ, Guerin ME.

Nat Commun. 2018 May 14;9(1):1874. doi: 10.1038/s41467-018-04300-x.

9.

Top-Down Chemoenzymatic Approach to Synthesizing Diverse High-Mannose N-Glycans and Related Neoglycoproteins for Carbohydrate Microarray Analysis.

Toonstra C, Wu L, Li C, Wang D, Wang LX.

Bioconjug Chem. 2018 Jun 20;29(6):1911-1921. doi: 10.1021/acs.bioconjchem.8b00145. Epub 2018 May 22.

PMID:
29738673
10.

Site-specific immobilization of endoglycosidases for streamlined chemoenzymatic glycan remodeling of antibodies.

Li T, Li C, Quan DN, Bentley WE, Wang LX.

Carbohydr Res. 2018 Mar 22;458-459:77-84. doi: 10.1016/j.carres.2018.02.007. Epub 2018 Feb 15.

PMID:
29475193
11.

Implementation of Glycan Remodeling to Plant-Made Therapeutic Antibodies.

Bennett LD, Yang Q, Berquist BR, Giddens JP, Ren Z, Kommineni V, Murray RP, White EL, Holtz BR, Wang LX, Marcel S.

Int J Mol Sci. 2018 Jan 31;19(2). pii: E421. doi: 10.3390/ijms19020421.

12.

Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses.

Cai H, Orwenyo J, Giddens JP, Yang Q, Zhang R, LaBranche CC, Montefiori DC, Wang LX.

Cell Chem Biol. 2017 Dec 21;24(12):1513-1522.e4. doi: 10.1016/j.chembiol.2017.09.005. Epub 2017 Oct 26.

13.

Designer α1,6-Fucosidase Mutants Enable Direct Core Fucosylation of Intact N-Glycopeptides and N-Glycoproteins.

Li C, Zhu S, Ma C, Wang LX.

J Am Chem Soc. 2017 Oct 25;139(42):15074-15087. doi: 10.1021/jacs.7b07906. Epub 2017 Oct 16.

14.

Chemoenzymatic Glycan Remodeling of Natural and Recombinant Glycoproteins.

Yang Q, Wang LX.

Methods Enzymol. 2017;597:265-281. doi: 10.1016/bs.mie.2017.06.006. Epub 2017 Jul 5.

15.

One-pot enzymatic glycan remodeling of a therapeutic monoclonal antibody by endoglycosidase S (Endo-S) from Streptococcus pyogenes.

Tong X, Li T, Orwenyo J, Toonstra C, Wang LX.

Bioorg Med Chem. 2018 Apr 1;26(7):1347-1355. doi: 10.1016/j.bmc.2017.07.053. Epub 2017 Jul 29.

PMID:
28789910
16.

Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody-drug conjugates.

Tang F, Wang LX, Huang W.

Nat Protoc. 2017 Aug;12(8):1702-1721. doi: 10.1038/nprot.2017.058. Epub 2017 Jul 27.

17.

Revisiting the substrate specificity of mammalian α1,6-fucosyltransferase reveals that it catalyzes core fucosylation of N-glycans lacking α1,3-arm GlcNAc.

Yang Q, Zhang R, Cai H, Wang LX.

J Biol Chem. 2017 Sep 8;292(36):14796-14803. doi: 10.1074/jbc.M117.804070. Epub 2017 Jul 20.

18.

Conformational Heterogeneity of the HIV Envelope Glycan Shield.

Yang M, Huang J, Simon R, Wang LX, MacKerell AD Jr.

Sci Rep. 2017 Jun 30;7(1):4435. doi: 10.1038/s41598-017-04532-9.

19.

Antibody against Microbial Neuraminidases Recognizes Human Sialidase 3 (NEU3): the Neuraminidase/Sialidase Superfamily Revisited.

Feng C, Li J, Snyder G, Huang W, Goldblum SE, Chen WH, Wang LX, McClane BA, Cross AS.

MBio. 2017 Jun 27;8(3). pii: e00078-17. doi: 10.1128/mBio.00078-17.

20.

Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies.

Cai H, Orwenyo J, Guenaga J, Giddens J, Toonstra C, Wyatt RT, Wang LX.

Chem Commun (Camb). 2017 May 14;53(39):5453-5456. doi: 10.1039/c7cc02059g. Epub 2017 May 3.

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